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Gustavo N. Marta Fernando F. de Arruda Fabiana A. Miranda Alice R.N.S. Silva Wellington F.P. Neves-Junior Anselmo Mancini Samir A. Hanna Carlos E.C.V. Abreu Joo Luis F. da Silva Jose Eduardo V. Nascimento Cecília Maria K. Haddad Fabio Y. Moraes Rafael Gadia 《Reports of Practical Oncology and Radiotherapy》2021,26(5):756
BackgroundThis study aims to assess the clinical outcomes of patients with spine metastases who underwent stereotactic ablative radiation therapy (SABR) as part of their treatment. SABR has arisen as a contemporary treatment option for spinal metastasis patients with good prognoses.Materials and methodsBetween November 2010 and September 2018, Spinal SABR was performed in patients with metastatic disease in different settings: radical (SABR only), postoperative (after decompression and/or fixation surgery), and reirradiation. Local control (LC), pain control, overall survival (OS) and toxicities were reported.ResultsEighty-five patients (corresponding to 96 treatments) with spine metastases were included. The median age was 59 years (range, 23–91). In most SA BR (82.3%, n = 79) was performed as the first local spine treatment, while in 12 settings (12.5%), fixation and/or decompression surgery was performed prior to SABR. Two-year overall survival rate was 74.1%, and median survival was 19 months. The LC rate at 2 years was 72.3%. With regard to pain control, among 67 patients presenting with pain before SA BR, 83.3% had a complete response, 12.1% had a partial response, and 4.6% had progression. Vertebral compression fractures occurred in 10 patients (11.7%), of which 5 cases occurred in the reirradiation setting. Radiculopathy and myelopathy were not observed. No grade III or IV toxicities were seen.ConclusionThis is the first study presenting a Brazilian experience with spinal SA BR, and the results confirm its feasibility and safety. SABR was shown to produce good local and pain control rates with low rates of adverse events. 相似文献
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Gupta Ankur Gadia Rohit Singh Ankit Singh Rajat Kumar Tiwari Akhilesh 《Plasmonics (Norwell, Mass.)》2022,17(1):143-151
Plasmonics - This paper dealt with the analysis of a surface plasmon resonance (SPR)-based D-shape photonic crystal fiber (PCF) biosensor for the detection of multimolecules present in a single... 相似文献
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