排序方式: 共有16条查询结果,搜索用时 31 毫秒
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Activation of the NOP receptor by the endogenous ligand nociceptin/orphanin FQ (N/OFQ) reduces alcohol consumption in genetically selected alcohol-preferring Marchigian Sardinian (msP) rats. The present study evaluated the effect of three newly synthesized peptidergic and one brain-penetrating heterocyclic NOP receptor agonists on alcohol drinking in the two bottle choice paradigm. MsP rats were intracerebroventricularly (ICV) injected with the NOP receptor agonists OS-462 (0.5 and 1.0 μg), UFP-102 (0.25 and 1.0 μg) or UFP-112 (0.01 and 0.05 μg), or with Ro 64-6198 (0.3 and 1.0 mg/kg) given intraperitoneally (i.p.) and tested for 10% alcohol consumption. Results showed decreased alcohol consumption after treatment with all three peptidergic NOP receptor agonists (OS-462, UFP-102 and UFP-112). OS-462 (at the 1.0 μg dose) and UFP-102 (at the 0.25 μg dose) induced a significant increase in food intake as well. Surprisingly, Ro 64-6198 was ineffective at the 0.3 mg/kg dose, whereas it increased ethanol and food consumption at the 1.0 mg/kg dose. Pre-treatment with the selective μ-receptor antagonist naloxone (0.5 mg/kg, i.p.) reduced these effects of 1.0 mg/kg of Ro 64-6198. These findings confirm that activation of brain NOP receptors reduces alcohol drinking in msP rats and demonstrate that OS-462, UFP-102 and UFP-112 act as potent NOP receptor agonists. On the other hand, Ro 64-6198 increased alcohol drinking, an effect probably induced by a residual agonist activity of this compound at μ-opioid receptors. Overall, the results indicate that OS-462, UFP-102 and UFP-112 may represent valuable pharmacological tools to investigate the functional role of the brain N/OFQ system. 相似文献
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O. N. Manousos J. C. Economidou D. E. Georgiadou K. G. Pratsika-Ougourloglou S. J. Hadziyannis G. E. Merikas K. Henry W. F. Doe 《BMJ (Clinical research ed.)》1974,2(5916):409-412
Clinical, immunological, and histological recovery in a patient with alpha-chain disease is described. The patient, a 27-year-old Greek man, presented with severe steatorrhoea, abdominal pain, oedema, and hypogammaglobulinaemia. Treatment with tetracycline produced only temporary remission. Intermittent therapy with prednisone and cyclophosphamide together with antibiotics was followed by clinical recovery, return of histological appearances of the small intestine to normal, and disappearance of free alpha-chain protein from the serum. The patient remained well one year later without treatment. 相似文献
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Konstantinos Stefanidis Dimitris Loutradis Vasiliki Anastasiadou Panagiotis Beretsos Ritsa Bletsa Vasiliki Dinopoulou Kaliopi Lekka Evangelia Elenis Erasmia Kiapekou Stauros Koussoulakos Anastasios Fotinos Aris Antsaklis 《Bio Systems》2009,98(2):122-126
Oxytocin is a nine amino acid peptide involved in a wide spectrum of physiological functions; predominantly those concerning reproduction and differentiation are of interest. Oxytocin receptors are expressed at early developmental stages of mammals, suggesting that oxytocin might be involved in the determination of the germ stem cell line, at the very early stages of mammalian development. In this respect, the proximate aim of the present study was to confirm and further analyze the existence of oxytocin receptors at a very early level of cell commitment, that is, the determination of germ cells derived from embryoid bodies. To achieve our purpose we have cultured mouse embryonic stem cells under conditions inducing formation of embryoid bodies. In this work, ES cells were allowed to aggregate in a novel medium, “Stefanidis medium” from day 0 to day 14 until formed EBs. RNA was isolated from EBs and using RT-PCR we showed that EBs expressed Oct-4, OTR, OT, and DAZL. To demonstrate simultaneous expression immunocytochemistry was preformed, in which EBs showed strong immunoreactivity for both, OTR and DAZL molecular markers. We found that 35% of the cells displayed OTR, using flow cytometry. In addition, this novel medium showed to increase OTR mRNA. We propose, that at least in murine induced embryoid bodies there is simultaneous expression of oxytocin receptors and germ cell markers (DAZL) in many cells (expressing Oct-4). We thus conclude that, the oxytocin might indeed be a molecule playing a leading role in germ cell determination. 相似文献
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T Economopoulos J Economidou E Papageorgiou J Dervenoulas C Christodoulides V Pappa D Karakassis C Terzoglou S Athanassiadou G Chalevelakis 《Blut》1989,58(1):7-9
The incidence of monoclonal gammopathy in 61 patients with chronic myeloproliferative disorders (CMPD) was studied. The distribution of patients among the CMPD subgroups was: chronic myelocytic leukemia, 24 patients; myelofibrosis, 11; polycythemia vera, 15; essential thrombocythemia, 7; unclassified MPD, 4 patients. Monoclonal gammopathy was found in 5 patients (8.2%). Two of these patients (1 IgA/k and 1 IgM/k) had myelofibrosis and 3 (2 IgG/k and 1 IgG/lambda) polycythemia vera. The presence of monoclonal gammopathy indicates an involvement of the lymphoplasmatic system in CMPD. 相似文献
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Erasmia Giannakou Nickos Aggeloussis Adamantios ArampatzisAuthor vitae 《Journal of electromyography and kinesiology》2011,21(6):1081-1086
The purpose of this study was to assess the reproducibility of fascicle length (FL) and pennation angle (PA) of gastrocnemius medialis (GM) muscle during running in vivo. Twelve male recreational long distance runners (mean ± SD; age: 24 ± 3 years, mass: 76 ± 7 kg) ran on a treadmill at a speed of 3.0 m/s, wearing their own running shoes, for two different 10 min sessions that were at least 2 days apart. For each test day 10 acceptable trials were recorded. Ankle and knee joint angle data were recorded by a Vicon 624 system with three cameras operating at 120 Hz. B-mode ultrasonography was used to examine fascicle length and pennation angle of gastrocnemius medialis muscle. The ultrasound probe was firmly secured on the muscle belly using a lightweight foam fixation. The results indicated that fascicle length and pennation angle demonstrated high reproducibility values during treadmill running both for within and between test days. The root mean square scores between the repeated waveforms of pennation angle and fascicle length were small (∼2° and ∼3.5 mm, respectively). However, ∼14 trials for pennation angle and ∼9 trials for fascicle length may be required in order to record accurate data from muscle architecture parameters. In conclusion, ultrasound measurements may be highly reproducible during dynamic movements such as treadmill running, provided that a proper fixation is used in order to assure the constant location and orientation of the ultrasound probe throughout the movement. 相似文献
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Background, Aims and Scope Telework is associated with a number of costs and benefits, including reduced company overhead costs, need for office and
parking space, office energy consumption, increased productivity, reduced absenteeism, retention of specialized employees,
reduction in transportation-related fuel consumption and air pollution, and many others. This paper applies a systems model
to telework and nontelework scenarios to quantify direct energy and fuel costs and external costs related to air emissions
from transportation, heating, cooling, lighting, and electronic and electrical equipment use both at the company and the home
office, including rebound effects.
Methods E-COMMUTair, a scalable web-based tool created by the authors and designed to assess the air pollution effects of individual
or company telework programs versus nontelework is employed along with Monte Carlo simulation and sensitivity analysis. E-COMMUTair
is using the latest available U.S. energy use and air emission factors. The external costs of air emissions are estimated.
The role of telecommuting frequency is emphasized, and differences between various states are explored. The paper identifies
the drivers of external costs, and presents an example breakeven analysis focused on CO2 and key model parameters.
Results and Discussion Nontelework’s external costs are equal to or higher than telework’s costs for every model component, demonstrating that telework
programs could provide benefits, including monetary benefits, to society. Transportation is the major contributor to the total
costs, with home heating and cooling, and office cooling following. Most of the monetary costs associated with transportation
are borne by individuals rather than society. Teleworking employees increase their home-related expenses but reduce their
travel-related expenses, ending up with smaller total costs. Energy and fuel costs get reduced in the office space when telework
programs are applied, resulting in benefits to companies. Energy and external costs decrease as telework frequency increases.
When compared to not teleworking, 5-day telework scenarios on cooling days in California can have about 50–70% lower total
costs. The probabilistic analysis confirms the results of the deterministic analysis. The sensitivity analysis reveals that
for the nontelework scenario, transportation-related variables such as commuting distance and average number of passengers
affect CO2, CO, and NOx emissions, while for the telework part, frequency and the number of roundtrips are the most relevant.
Conclusions Both analyses show that telework programs have the potential to lower both energy and external costs creating a favorable
bottom line for society, employees, and companies by decreasing tailpipe emissions, lowering transportation costs, and decreasing
energy costs at the company office. However, important parameters such as telecommuting frequency, characteristics of the
office and home space, climate patterns, and rebound effects that determine external costs along with the price of gasoline,
electricity and natural gas in the state where the program is implemented can greatly influence the final results, and should
be carefully examined.
Recommendations and Perspectives The effects of telework programs on people’s daily lives are complex and difficult to predict and quantify. The current analysis
showed that significant financial benefits can be expected from telework programs, but as seen often in environmental policy-making,
the details of implementation will make or break the success of a program.
formerly Postdoctoral Researcher, University of California, Berkeley
ESS-Submission Editor: Dr. Gerald Rebitzer (Gerald.Rebitzer@alcan.com) 相似文献
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Don Tills Andrew Warlow Jayne M. Lord Diana Suter Ada C. Kope Baruch S. Blumberg Jana E. Hesser Ioanna Economidou 《American journal of physical anthropology》1983,61(2):145-156
One-thousand, thirty-eight individuals from Plati, Greece were examined for the following red cell antigens, serum proteins, and red cell enzymes A A1 Ai B H; MNSs Mg Henshaw Nya Mur Vw; CCwcDEeCe; K k Kpa Kpb Jsa Jsb; P1; Lua; Fy1 Fy2; Jka Jkb; Wra; Zt; Vel; Swa; Jensen, Radin, Gerbich, Diego, Gregory, Haptoglobin, Transferrin, Acid phosphatase, Adenylate kinase, Adenosine deaminase, Esterase-D, Glucose-6-phosphate dehydrogenase, Phosphoglucomutase, 6-Phosphogluconate dehydrogenase, Phosphohexose isomerase, Lactate dehydrogenase, Malate dehydrogenase, and Superoxide dismutase. The results are discussed in detail and compared with other Greek and neighbouring populations. Because of the Plati population's long history of residence in the Cappadocian area of Turkey the data have been compared, whenever possible, with results for that region. 相似文献
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G Papaevangelou G Fr?sner J Economidou S Parcha A Roumeliotou 《BMJ (Clinical research ed.)》1978,1(6114):689-691
Evidence of hepatitis B virus (HBV) and hepatitis A virus (HAV) infections was south in 148 multiply transfused patients with thalassaemia and in healthy controls (2040 for HBV and 217 for HAV). The prevalence of the HBV surface antigen or antibody to it was significantly higher in patients than in controls and increased with the number of blood transfusions. In contrast, the prevalence of antibody to HAV was significantly lower in patients than in controls and decreased with the number of blood transfusions. These results support the view that blood transfusion does not play any appreciable part in transmitting HAV. Indeed, regular blood transfusion, where donors almost all have HAV antibody, seems to give protection against infection. 相似文献
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