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排序方式: 共有159条查询结果,搜索用时 78 毫秒
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V M Shcherbakov Y N Dubrov E N Korneva L D Molchanova V M Semenov SYuDevichensky 《Biochemical and biophysical research communications》1991,179(2):945-953
We confirmed that NADPH-dependent anaerobic amaranch reduction in rat liver microsomes is compatible with the interaction of the dye with Fe(III) heme of cytochrome P-450 as the type II substrate. This process is rate-limiting in the whole reaction. High positive correlation (r = 0.949) between the values of Vmax for reaction of NADPH-dependent anaerobic amaranch reduction and the relative content low spin forms of cytochrome P-450 determined by ESR in microsomes from liver of control and induced by PB, BP, IS and 4-MP rats was observed. Relative content of low spin forms of cytochrome P-450 determined by ESR was increased according to BP less than PB less than control less than IS approximately 4-MP; Vmax values increased according to BP less than PB less than control less than IS less than 4-MP. Thus, reaction of NADPH-dependent anaerobic amaranch reduction may be used for determination of low spin forms of cytochrome P-450 at physiological conditions. 相似文献
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The ultrastructure of the mid-intestine of four sturgeon species and their hybrids was studied. Apart from enterocytes and
glandular goblet cells, the cells with microvilli, endocrine cells, and immunocompetent elements were revealed. Specific cells
responsible for the primary immune response, analogous to mammalian M-cells, were discovered in sturgeon fishes. The ultrastructural characteristics common for the mid-intestinal epithelium of
all the sturgeon fishes studied were determined. Species-specific features of intestinal epithelium of the parent species,
which were characteristic of the hybrids, were revealed. 相似文献
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Abramov I. S. Korneva Yu. S. Shisterova O. A. Ikonnikova A. Yu. Emelyanova M. A. Lisitsa T. S. Krasnov G. S. Nasedkina T. V. 《Molecular Biology》2021,55(3):354-362
Molecular Biology - Molecular profiling of tumors may provide promising options for personalized treatment. We have examined the spectrum of germline and somatic mutations in 23 breast cancers (BC)... 相似文献
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Korneva ZhV 《Parazitologiia》2004,38(2):150-159
The fine structure of the female reproductive organs and ducts in two cyclophyllidean cestodes was studied by transmission electron microscopy. All the studied ducts (vitelline, fertilization and vaginal ducts, and oviducts) as well as the uterine and ootype walls have the luminal surface elevated to form apical cytoplasmic lamellae and are surrounded by bands of circular muscules, which are attached to the basement layer. The structure of the studied ducts epithelium corresponds to the pattern described in other ducts of the cestode genital system, namely a nucleate syncytial layer. An exception is the vagina Sobolevicanthus gracilis, in which the surface is lined with not numerous atypical microtriches. The comparison of our results and the data reported for other species is given. It is found out that in different species of cestodes forming oligolecital eggs, there are observed various uterine structures and diverse contacts between the eggs capsules and the uterine epithelium. The formation of special structures and contacts is the evolutionary way from the extrauterine type to more progressive intrauterine type of embryo development in cestodes. 相似文献
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C. ALBUQUERQUE F. MORINHA J. MAGALHÃES J. REQUICHA I. DIAS H. GUEDES-PINTO E. BASTOS C. VIEGAS 《Journal of genetics》2015,94(4):651-659
Elevated levels of interleukin-1 (IL-1) have been shown to amplify the inflammatory response against periodontopathogenic bacteria. In humans, polymorphisms in the IL1A and IL1B genes are the most well-studied genetic polymorphisms associated with periodontal disease (PD). In contrast to human, there is a lack of knowledge on the genetic basis of canine PD. A case–control study was conducted in which a molecular analysis of dog IL1A and IL1B genes was performed. Of the eight genetic variants identified, seven in IL1A gene and one in IL1B gene, IL1A/1_g.388A >C and IL1A/1_g.521T >A showed statistically significant differences between groups (adjusted OR (95% CI): 0.15 (0.03–0.76), P= 0.022; 5.76 (1.03–32.1), P= 0.046, respectively). It suggests that in the studied population the IL1A/1_g.388C allele is associated with a decreased PD risk, whereas the IL1A/1_g.521A allele can confer an increased risk. Additionally, the IL1A/2_g.515G >T variation resulted in a change of amino acid, i.e. glycine to valine. In silico analysis suggests that this change can alter protein structure and function, predicting it to be deleterious or damaging. This work suggests that IL1 genetic variants may be important in PD susceptibility in canines. 相似文献
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Kazakova TB Novikova NS Korneva EA 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2006,92(6):677-691
The results of investigations of the new discovered brain orexin neurons, their chemical structure, localization and functions are reviewed. The following data are described: the specifics of orexins mRNA, orexins A and B and their receptors; connections between orexin neurons and neurons from different structures of the brain and spinal cord and the participation of the orexin neuron system in the functional regulation. 相似文献
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