排序方式: 共有31条查询结果,搜索用时 15 毫秒
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Jun Lei Hongjian Wang Daoming Zhu Yibin Wan Lei Yin 《Journal of cellular physiology》2020,235(5):4814-4823
CD8+ T cells play a vital role in cancer immunotherapy and can be shaped by metabolism. Avasimibe is an acyl coenzyme A-cholesterol acyltransferase (ACAT) inhibitor, which has been clinically verified safe in other phase Ⅲ clinical trials. It can potentiate the killing function of CD8+ T cells by modulating cholesterol metabolism. Doxorubicin (DOX) is an anticancer drug widely used in many cancers to induce tumor cell apoptosis. Unfortunately, DOX also can induce toxic and side effects in many organs, compromising its usage and efficacy. Herein, we report the combinational usage of avasimibe and a safe pH sensitive nano-drug delivery system composing of DOX and metal–organic frameworks nanoparticles (MNPs). Our findings demonstrated that DOX–MNPs treatment inhibited tumor growth with good safety profile and avasimibe treatment combined DOX–MNPs treatment exhibited a better efficacy than monotherapies in 4T1 breast cancer therapy. 相似文献
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Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells 总被引:2,自引:0,他引:2
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Shi L Qiu D Zhao G Corthesy B Lees-Miller S Reeves WH Kao PN 《Nucleic acids research》2007,35(7):2302-2310
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Hai‐tao Zheng Yun Gong Feng Chen Huan Lei Daoming Huang 《Zeitschrift fur angewandte Ichthyologie》2018,34(5):1258-1260
Length‐weight relationships (LWRs) were determined for nine fish species occurring in the Nujiang River. Fish were collected using gill nets, including two nets of 1.0 m depth (100 m long; mesh size 0.5 cm), two nets of 1.0 m depth (150 m long; mesh size 2.0 cm) and two nets reaching 1.5 m depth (mesh size 6.0 cm). Gill nets were set over night including different habitats (riffles and pools, vegetated and non vegetated zones) from four sections in July of the following 2 years: 2004 and 2008. The LWRs presented here include for all nine studied species (Pseudexostoma brachysoma Chu, 1979, Creteuchiloglanis gongshanensis [Chu, 1981], Glyptothorax zanaensis Wu, He & Chu, 1981, Glyptothorax dorsalis Vinciguerra, 1890, and Glyptothorax trilineatus Blyth, 1860, Schizothorax gongshanensis Tsao, 1964, Schizothorax meridionalis Tsao, 1964, Placocheilus cryptonemus Cui & Li, 1984, and Schistura longa [Zhu, 1982]), and new maximum standard length of four species not yet reported in the literature. 相似文献
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Anla Hu Li Li Chuanlai Hu Daoming Zhang Chen Wang Yan Jiang Meng Zhang Chunmei Liang Wenjun Chen Qingli Bo Qihong Zhao 《Biological trace element research》2018,182(1):21-28
Data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on hormonal profiles, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS) are scarce. The objective of this study was to assess the effects of magnesium-zinc-calcium-vitamin D co-supplementation on hormonal profiles, biomarkers of inflammation, and oxidative stress in women with PCOS. Sixty PCOS women were randomized into two groups and treated with 100 mg magnesium, 4 mg zinc, 400 mg calcium plus 200 IU vitamin D supplements (n = 30), or placebo (n = 30) twice a day for 12 weeks. Hormonal profiles, biomarkers of inflammation, and oxidative stress were assessed at baseline and at end-of-treatment. After the 12-week intervention, compared with the placebo, magnesium-zinc-calcium-vitamin D co-supplementation resulted in significant reductions in hirsutism (?2.4 ± 1.2 vs. ?0.1 ± 0.4, P < 0.001), serum high sensitivity C-reactive protein (?0.7 ± 0.8 vs. +0.2 ± 1.8 mg/L, P < 0.001), and plasma malondialdehyde (?0.4 ± 0.3 vs. +0.2 ± 1.0 μmol/L, P = 0.01), and a significant increase in plasma total antioxidant capacity concentrations (+46.6 ± 66.5 vs. ?7.7 ± 130.1 mmol/L, P = 0.04). We failed to find any significant effect of magnesium-zinc-calcium-vitamin D co-supplementation on free androgen index, and other biomarkers of inflammation and oxidative stress. Overall, magnesium-zinc-calcium-vitamin D co-supplementation for 12 weeks among PCOS women had beneficial effects on hormonal profiles, biomarkers of inflammation, and oxidative stress. 相似文献
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Lianmin Chen Daoming Wang Sanzhima Garmaeva Alexander Kurilshikov Arnau Vich Vila Ranko Gacesa Trishla Sinha Eran Segal Rinse K. Weersma Cisca Wijmenga Alexandra Zhernakova Jingyuan Fu 《Cell》2021,184(9):2302-2315.e12
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Length‐weight relationships for three fishes in the Mali Hka River and Nmai Hka River,Myanmar
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Hai‐Tao Zheng Yun Gong Feng Chen Yinquan Liang Daoming Huang 《Zeitschrift fur angewandte Ichthyologie》2018,34(5):1228-1229
Length‐weight relationships (LWRs) were investigated for three fish species occurring in the Mali Hka River and Nmai Hka River. Fish were collected monthly from five sites between January and May 2009, using gill nets in the main river and electrofishing in tributaries (gill nets of three types: (a) = 10 m long, 0.5 m depth, 0.5 cm mesh size); (b) = 15 m long, 1 m depth, 2.0 cm mesh size; and (c) = 20 m long, 1.5 m depth, 6.0 cm mesh size. Soaking time for all was 24 hr). The LWRs for Botia histrionica Blyth, 1860, Crossocheilus burmanicus Hora, 1936 and Schizothorax grahami (Regan, 1904) are given in Table 1 along with the appropriate statistics for the parameters a and b of the equation as well as the confidence intervals and the correlation coefficient. All values of parameter b ranging from 2.57 for Botia histrionica Blyth, 1860 and 3.19 for Crossocheilus burmanicus Hora, 1936 (in all cases r2 > 0.96). A new total length has been recorded for Schizothorax grahami (Regan, 1904) when comparing with records given in the international electronic databank FishBase (Froese & Pauly, 2018). 相似文献
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服用“乳珍”后,实验动物的迷宫训练次数显著减少(p<0.05),腹腔巨噬细胞总数和吞噬指数明显提高(p<0.01)。人群试验显示,服“乳珍”者血浆游离牛磺酸和全血血红蛋白浓度明显上升(p<0.01),受试者体质得到改善。 相似文献