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Stanisław Gill Wanda Dembińska-Migas Maria Zielińska-Stasiek Włlodzimierz Maria Daniewski Andrzej Wawrzuń 《Phytochemistry》1983,22(2):599-600
The aerial parts of Gaillardia aristata afforded a new pseudoguaianolide, 9-O-desacetylspathulin-2-O-2-methylbutanoate. 相似文献
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M Kobus E Krawczyk P Kopczacki W Daniewski M ?uczak 《Medycyna do?wiadczalna i mikrobiologia》2001,53(3):283-289
The study comprised newly synthesized sesquiterpenoid analogs of taxol. The synthesis of the compounds was performed at the Institute of Organic Chemistry, Polish Academy of Sciences. Cytotoxicity of the compound was assessed using formazan method. In in vitro studies the cell cultures were infected with HSV-1MC. The tested compounds were added in different concentrations to the cell culture after viral infection. Titer of the virus was expressed in TCID50/ml at particular stages of the experiments. In in vivo experiments NMRI mice were infected intramuscularly with a Moloney murine sarcoma virus (Mo-MSV). Tested compounds were administered to the mice intravenously on the day of virus inoculation. In Mo-MSV-infected mice dynamics of tumor progression and regression was assessed, as well as a mean time interval of tumor disappearance. Among the compounds tested: isovellerol-13-N-benzoyl-(2'R,3'S)-3'-phenylisoserinate, 5-deoxy-lactarolid B 8-[N-benzoyl-(2'R,3'S)-3'-phenylisoserinate] and isolactarorufin 8-epi-[N-benzoyl-(2'R,3'S)-3'-phenylisoserinate] showed significant antiviral activity in in vitro experiments. In in vivo experiments only lactarorufin A 8-[N-benzoyl-(2'R,3'S)-3'-phenylisoserinate] significantly inhibited the development of tumors and shortened the time of their total regression in the course of Mo-MSV infection. 相似文献
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Biological activities of the salannin type of limonoids isolated fromAzadirachta indica A. Juss were assessed using the gram pod borerHelicoverpa armigera (Hubner) and the tobacco armywormSpodoptera litura (Fabricius) (Lepidoptera: Noctuidae). Inhibition of larval growth was concomitant with reduced feeding by neonate and third
instar larvae. All three compounds exhibited strong antifeedant activity in a choice leaf disc bioassay with 2.0, 2.3 and
2.8 (μ/cm2 of 3-O-acetyl salannol, salannol and salannin, respectively deterring feeding by 50% inS. litura larvae. In nutritional assays, all three comounds reduced growth and consumption when fed to larvae without any effect on
efficiency of conversion of ingested food (ECI), suggesting antifeedant activity alone. No toxicity was observed nor was there
any significant affect on nutritional indices following topical application, further suggesting specific action as feeding
deterrents. When relative growth rates were plotted against relative consumption rates, growth efficiency of theH. armigera fed diet containing 3-O-acetyl salannol, salannol or salannin did not differ from that of starved control larvae (used as
calibration curve), further confirming the specific antifeedant action of salannin type of limonoids. Where the three compounds
were co-administered, no enhancement in activity was observed. Non-azadirachtin limonoids having structural similarities and
explicitly similar modes of action, like feeding deterrence in the present case, have no potentiating effect in any combination. 相似文献
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Jin-Jun Liu Irena Daniewski Qingjie Ding Brian Higgins Grace Ju Kenneth Kolinsky Fred Konzelmann Christine Lukacs Giacomo Pizzolato Pamela Rossman Amy Swain Kshitij Thakkar Chung-Chen Wei Dorota Miklowski Hong Yang Xuefeng Yin Peter M. Wovkulich 《Bioorganic & medicinal chemistry letters》2010,20(20):5984-5987
A novel series of pyrazolobenzodiazepines 3 has been identified as potent inhibitors of cyclin-dependent kinase 2 (CDK2). Their synthesis and structure–activity relationships (SAR) are described. Representative compounds from this class reversibly inhibit CDK2 activity in vitro, and block cell cycle progression in human tumor cell lines. Further exploration has revealed that this class of compounds inhibits several kinases that play critical roles in cancer cell growth and division as well as tumor angiogenesis. Together, these properties suggest a compelling basis for their use as antitumor agents. 相似文献
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Synthesis and antifeedant properties of N-benzoylphenylisoserinates of Lactarius sesquiterpenoid alcohols. 总被引:2,自引:0,他引:2
P Kopczacki M Gumulka M Masnyk H Grabarczyk G Nowak W M Daniewski 《Phytochemistry》2001,58(5):775-787
The esterification of various sesquiterpenoid alcohols of Lactarius origin with N-benzoyl-[2R,3S]-phenylisoserine (side chain of Taxol) produced compounds whose antifeedant properties against storage pests Tribolium confusum, Trogoderma granarium and Sitophylus granarius were measured. The introduction of the taxol side chain in these molecules, in comparison to original compounds, moderately enhanced their antifeedant activities, as well as changed their selectivity of activity towards the test insects. 相似文献
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Wlodzimierz Maria Daniewski Paul A. Grieco John C. Huffman Apoloniusz Rymkiewicz Andrzej Wawrzun 《Phytochemistry》1981,20(12):2733-2734
A new sesquiterpene, 12-hydroxycaryophyllene-4,5-oxide, has been isolated from the ethanolic extract of Lactarius camphoratus. The structure, stereochemistry and absolute configuration were determined by a combination of spectral data and single-crystal X-ray analysis of the p-bromobenzoate derivative. 相似文献
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