全文获取类型
收费全文 | 467篇 |
免费 | 18篇 |
出版年
2023年 | 8篇 |
2022年 | 6篇 |
2021年 | 10篇 |
2020年 | 11篇 |
2019年 | 11篇 |
2018年 | 10篇 |
2017年 | 17篇 |
2016年 | 20篇 |
2015年 | 12篇 |
2014年 | 21篇 |
2013年 | 37篇 |
2012年 | 32篇 |
2011年 | 29篇 |
2010年 | 16篇 |
2009年 | 14篇 |
2008年 | 23篇 |
2007年 | 28篇 |
2006年 | 35篇 |
2005年 | 23篇 |
2004年 | 18篇 |
2003年 | 22篇 |
2002年 | 19篇 |
2001年 | 10篇 |
2000年 | 3篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1997年 | 4篇 |
1996年 | 3篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1989年 | 3篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1977年 | 3篇 |
1976年 | 4篇 |
1975年 | 2篇 |
1972年 | 3篇 |
1970年 | 2篇 |
1968年 | 5篇 |
1967年 | 1篇 |
排序方式: 共有485条查询结果,搜索用时 375 毫秒
1.
Kepenek Eda Seyma Ozcinar Evren Tuncay Erkan Akcali Kamil Can Akar Ahmet Ruchan Turan Belma 《Molecular and cellular biochemistry》2020,463(1-2):33-44
Molecular and Cellular Biochemistry - Excitation–contraction coupling in normal cardiac function is performed with well balanced and coordinated functioning but with complex dynamic... 相似文献
2.
Eda Dagsuyu Pınar Koroglu Ilknur B. Gul Omur K. Bulan Refiye Yanardag 《Journal of biochemical and molecular toxicology》2023,37(10):e23440
The body can host the spread of prostate cancer cells. Metastases from prostate cancer are more frequently seen in the brain, liver, lungs, and lymph nodes. A well-known antidiabetic drug, metformin, is also known to have antitumor effects. Our study focuses on the evaluation of potential metformin protective effects on brain and cerebellum damage in streptozotocin (STZ)-induced diabetic and Dunning prostate cancer models. In this investigation, six groups of male Copenhagen rats were created: control, diabetic (D), cancer (C), diabetic + cancer (DC), cancer + metformin, and diabetic + cancer + metformin. The brain and cerebellum tissues of the rats were taken after sacrifice. Oxidative stress markers including reduced glutathione level, lipid peroxidation, glutathione reductase, glutathione peroxidase, glutathione-S-transferase, catalase, superoxide dismutase activities, reactive oxygen species, total oxidant and total antioxidant status, lactate dehydrogenase, xanthine oxidase, acetylcholinesterase activities, protein carbonyl contents, nitric oxide and OH-proline levels, sodium potassium ATPase, carbonic anhydrase, and glucose-6-phosphate dehydrogenase activities; glycoprotein levels including hexose, hexosamine, fucose, and sialic acid levels; and histone deacetylase activity as a cancer marker were determined. Oxidative stress markers were impaired and glycoprotein levels and histone deacetylase activity were increased in the D, C, and DC groups. Metformin therapy reversed these effects. Metformin was found to protect the brain and cerebellum of STZ-induced diabetic rats with Dunning prostate cancer from harm caused by MAT-Lylu metastatic cells. 相似文献
3.
İncili Çınar Yiğit Arslan Büşra Çelik Esra Nurten Yer Ulu Ferhat Horuz Erdoğan Baloglu Mehmet Cengiz Çağlıyan Ebrar Burcu Gamze Bayarslan Aslı Ugurlu Altunoglu Yasemin Celik 《Protoplasma》2023,260(2):509-527
Protoplasma - Watermelon and melon are members of the Cucurbitaceae family including economically significant crops in the world. The expansin protein family, which is one of the members of the... 相似文献
4.
Ulviye Acar Çevik Ismail Celik Ufuk İnce Zahra Maryam Iqrar Ahmad Harun Patel Yusuf Özkay Zafer Asım Kaplancıklı 《化学与生物多样性》2023,20(3):e202201146
In this work, the synthesis, characterization, and biological activities of a new series of 1,3,4-thiadiazole derivatives were investigated. The structures of final compounds were identified using 1H-NMR, 13C-NMR, elemental analysis, and HRMS. All the new synthesized compounds were then screened for their antimicrobial activity against four types of pathogenic bacteria and one fungal strain, by application of the MIC assays, using Ampicilin, Gentamycin, Vancomycin, and Fluconazole as standards. Among the compounds, the MIC values of 4 and 8 μg/mL of the compounds 3f and 3g , respectively, are remarkable and indicate that these compounds are good candidates for antifungal activity. The docking experiments were used to identify the binding forms of produced ligands with sterol 14-demethylase to acquire insight into relevant proteins. The MD performed about 100 ns simulations to validate selected compounds’ theoretical studies. Finally, using density functional theory (DFT) to predict reactivity, the chemical characteristics and quantum factors of synthesized compounds were computed. These results were then correlated with the experimental data. Furthermore, computational estimation was performed to predict the ADME properties of the most active compound 3f . 相似文献
5.
Microtubular structures, which were demonstrated as straight, dense-walled cylinders attached to cell membranes, were found in a stable staphylococcal L-form grown in the absence of antibiotic. 相似文献
6.
Corelike structures, which were interpreted as straight, large cylinders containing ribosome-like particles surrounded by
an amorphous substance of low electron density, were found in a stable L-form ofStreptococcus pyogenes grown in the absence of antibiotics. 相似文献
7.
Eighteen isolates if anaerobic coryneforms from human bone marrow and skin and four type strains of Propionibacterium were studied chemically, biochemically and antigenically. All of the isolates were identified as Propionibacterium acnes; of the 18 isolates,16 belonged to sterotype I and two to serotype II. By means of gas liquid chromatography and mass spectral analysis, a large amount of iso-type fatty acids, such as iso-pentadecanoic and iso-heptadecanoic acids were detected in whole cells of isolates and type strains. Antitumor and adjuvant effects of the isolates and type strains were found to differ considerably among the strains. One of the isolates, P. acnes C-7, which showed potent biological activities was fractionated by hot phenol-water extraction. The resulting insoluble middle layer was found the most effective in tumor protection, adjuvant action in immune response and phagocytic activity in mice. 相似文献
8.
Marcin Nowicki Logan C. Houston Sarah L. Boggess Anthony S. Aiello Miriam Pay‐Milans Margaret E. Staton Mitsuhiro Hayashida Masahiro Yamanaka Shigetoshi Eda Robert N. Trigiano 《Ecology and evolution》2020,10(15):8299-8312
Cornus kousa (Asian dogwood), an East Asia native tree, is the most economically important species of the dogwood genus, owing to its desirable horticultural traits and ability to hybridize with North America‐native dogwoods. To assess the species genetic diversity and to better inform the ongoing and future breeding efforts, we assembled an herbarium and arboretum collection of 131 noncultivated C. kousa specimens. Genotyping and capillary electrophoresis analyses of our C. kousa collection with the newly developed genic and published nuclear genomic microsatellites permitted assessment of genetic diversity and evolutionary history of the species. Regardless of the microsatellite type used, the study yielded generally similar insights into the C. kousa diversity with subtle differences deriving from and underlining the marker used. The accrued evidence pointed to the species distinct genetic pools related to the plant country of origin. This can be helpful in the development of the commercial cultivars for this important ornamental crop with increased pyramided utility traits. Analyses of the C. kousa evolutionary history using the accrued genotyping datasets pointed to an unsampled ancestor population, possibly now extinct, as per the phylogeography of the region. To our knowledge, there are few studies utilizing the same gDNA collection to compare performance of genomic and genic microsatellites. This is the first detailed report on C. kousa species diversity and evolutionary history inference. 相似文献
9.
Yilmaz Şehnaz Yoldas Oguz Dumani Aysin Guler Gizem Ilgaz Seda Akbal Eylül Oksuz Hale Celik Ayla Yilmaz Bertan 《Molecular biology reports》2020,47(7):5377-5383
Molecular Biology Reports - Antimicrobial irrigation solutions are widely used under clinical settings. Their effect on dental tissue is a subject of recent research, which aims for a safer... 相似文献
10.
Gungor Kanbak Kazım Kartkaya Eda Ozcelik Ahmet Burak Guvenal Sibel Canbaz Kabay Gul Arslan Ramazan Durmaz 《Gene》2013
Our aim in this study was to investigate the effect of moderate acute alcohol administration on cysteine protease mediated neuronal apoptosis and nitric oxide production in the traumatic brain injury. A total of 29 adult Sprague–Dawley male rats weighing 250–300 g were used. The rats were allocated into four groups. The first group was the control (sham-operated) group in which only a craniotomy was performed, the others were alcohol, trauma and trauma + alcohol groups. Caspase-3 enzyme activity in the trauma group increased significantly in comparison with the control group. The alcohol given group showed a decreased caspase-3 enzyme activity compared to the trauma group. The level of caspase-3 enzyme activity in the alcohol + trauma group decreased in comparison to the trauma group. SF/FEL ratio of cathepsin-L enzyme activity in the trauma group was significantly higher than in the control group. Our results indicate that moderate alcohol consumption may have protective effects on apoptotic cell death after traumatic brain injury. Protective effects of moderate ethanol consumption might be related to inhibition of lysosomal protease release and nitric oxide production. 相似文献