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Shailesh Kumar Atma P. Dwivedi Vivek Kr. Kashyap A.K. Saxena A.K. Dwivedi Ranjana Srivastava Devi P. Sahu 《Bioorganic & medicinal chemistry letters》2013,23(8):2404-2407
Synthesis of a library of novel trans 6-methoxy-1,1-dimethyl-2-phenyl-3-aryl-2,3-dihydro-1H-inden-4-yloxy alkyl amines and their antimycobacterial activity against drug sensitive and multidrug resistant strains of Mycobacterium tuberculosis have been reported. All the new compounds in the series exhibited MIC between 1.56 and 6.25 μg/ml. Two compounds 1i and 1j with low MIC and low cytotoxicity showed significant reduction in CFU in infected mouse macrophages at 1× MIC concentration. The compound 1i inhibited the growth of M. tuberculosis in mice at 100 mg/kg dose with 1.35 log10 reduction of CFU in lungs tissue and was active against non-replicating Mycobacterium tuberculosis under anaerobic condition. 相似文献
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A K Srivastava C Pandey K P Dwivedi V K Singh 《Indian journal of biochemistry & biophysics》1989,26(3):199-200
QSAR studies have been performed on the homologues of 3-triazines, using molecular connectivity index and van der Waal volume as structural parameters. The regression analysis has shown good correlation between antitumour activity and the two structural parameters. 相似文献
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Different preparations of chromatin isolated from mycelia of Neurospora crassa were analyzed for DNA-associated RNA and proteins. The UV absorption spectra, the ultrastructure of chromatin, and the amino acid composition of the acid-extractable proteins were studied. The protein:DNA ratios range from 1.5 to 2.8; the RNA:DNA ratios range from 0.5 to 1.24. UV absorption shows a macimum at 259 mµ and a minimum at 238–239 mµ. The E280/E260 ranges from 0.59 to 0.70. Electron microscopy reveals a fibrous structure with individual fibers of 120–150 A average diameter. Attempts were made to study the protein by polyacrylamide gel electrophoresis and amino acid analysis. The results indicate that Neurospora chromatin does not contain basic proteins comparable to calf thymus histone. The ratios of basic to acidic amino acids range from 0.93 to 1.19. On electrophoresis, no bands are seen whose positions correspond to those of histones. Staining for basic proteins with fast green or eosin Y at pH 8.2 also shows a negative reaction, suggesting the absence of histones. 相似文献
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The DNP derivative of sonicate antigens of the H37Ra strain ofMycobacterium tuberculosis (Ra-DNP) is known to induce marked B-cell proliferation. In order to understand whether B-cell proliferation in response
to Ra-DNP was antigen driven or represented a non-specific mitogenic effect of Ra-DNP, the effect of Ra-DNP was compared with
that of lipopolysaccharide a potent B-cell mitogen. Parameters used for comparison were (i) thymidine incorporation, (ii)
viable cell counts, (iii) amount of lg secreted, (iv) isotype profile of Ig released and (v) cell cycling pattern of B-cells
in culture. Overall the effect of Ra-DNP was found to be essentially similar to that of lipopolysaccharide for all parameters
examined. Yet quantitatively, the effect of the former was always relatively poorer. At optimal doses, the effect of Ra-DNP
ranged from 50 to 70% of the lipopolysaccharide effect in different assays. These results suggest that Ra-DNP may have a B-cell
mitogenic effect similar to the effect of lipopolysaccharide, but all B-cells may not respond to Ra-DNP. 相似文献
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Essential oils isolated from leaves and seeds of seven umbelliferous plants were tested against the growth ofAspergillus flavus. Those from seeds ofTrachyspermum ammi, Cuminum cyminum, Carum carvi, Daucus carota and from leaves ofAnethum graveolens exhibited antifungal activity against the test fungus. Amongst these, oil from seeds ofTrachyspermum ammi was most toxic. Its minimum inhibitory concentration was 300 ppm, at which it exhibited fungistatic but not phytotoxic properties, when tested at 200, 300 and 400 ppm. The fungitoxic potency ofTrachyspermum seed oil remained unchanged after a long storage period and at high inoculum density of the test fungus. The oil was thermostable and was more efficaceous than the fungicides Agrosan G.N., Benlate, Ceresan, Dithane M-45 and Thiovit commonly used for the control of plant diseases. 相似文献
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Chandra M. Dwivedi Laurence T. Plante Roy L. Kisliuk Edward J. Pastore Surendra P. Verma Donald F.H. Wallach 《Archives of biochemistry and biophysics》1982,213(1):338-340
Dihydrofolate reductase from Lactobacillus casei and its complexes with NADPH and methotrexate yield well-resolved Raman spectra. The 1685-cm?1 Raman band assigned to the carboxamide of NADPH persists in the NADPH-enzyme binary complex but is absent from the NADPH-methotrexate-enzyme ternary complex. This is ascribed to stabilization of the polarized form of the carboxamide by H bonding to the NH and CO groups of Ala 6 and Ile 13 of the peptide backbone. 相似文献