全文获取类型
收费全文 | 242篇 |
免费 | 6篇 |
专业分类
248篇 |
出版年
2022年 | 9篇 |
2021年 | 9篇 |
2020年 | 3篇 |
2019年 | 14篇 |
2018年 | 5篇 |
2017年 | 11篇 |
2016年 | 6篇 |
2015年 | 7篇 |
2014年 | 8篇 |
2013年 | 9篇 |
2012年 | 10篇 |
2011年 | 12篇 |
2010年 | 6篇 |
2009年 | 3篇 |
2008年 | 13篇 |
2007年 | 9篇 |
2006年 | 12篇 |
2005年 | 13篇 |
2004年 | 5篇 |
2003年 | 9篇 |
2002年 | 10篇 |
2001年 | 2篇 |
2000年 | 5篇 |
1999年 | 4篇 |
1996年 | 2篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1988年 | 7篇 |
1987年 | 4篇 |
1986年 | 6篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1978年 | 1篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1972年 | 1篇 |
1971年 | 2篇 |
1970年 | 1篇 |
1968年 | 1篇 |
1967年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有248条查询结果,搜索用时 15 毫秒
1.
L A Shcherbakova V V Kalashnikov Iu S Tatarinov V A Murashov D D Petrunin 《Biulleten' eksperimental'no? biologii i meditsiny》1987,103(5):606-607
It has been found that fertility alpha 2-microglobulin content in male and female serum does not exceed 20 ng/ml and 40 ng/ml, respectively. A high level of fertility alpha 2-microglobulin was found in the serum in early pregnancy, with its concentration decreased by parturition. 相似文献
2.
3.
In the yeast Dipodascus magnusii, which is auxotrophic for thiamine and biotin, during cultivation on glucose with excessive thiamine concentration, pyruvate metabolism was shown to result in the synthesis of fermentation products, namely, ethanol and, to a lesser extent, lactate. Substantial synthesis of ethyl acetate was also observed under these conditions. Introduction of nicotinic acid (NA) into the medium resulted in time separation of ethanol and lactate production. It was shown that cultivation of the yeast under biotin deficiency resulted in nearly complete suppression of aerobic production of ethanol and cessation of ethyl acetate synthesis, whereas lactate synthesis was activated as early as in the first hours of cultivation. Upon introduction of NA under these conditions, lactate concentration sharply increased. These results show that the combination of thiamine and biotin with other vitamins can stimulate utilization of the pyruvate pool in yeasts towards formation of considerable amounts of lactate, which is typical only of cells of higher eukaryotes and bacteria. 相似文献
4.
Bogdanova Alexandra Sergeevna Sokolova Anastasiia Ivanovna Pavlova Elizaveta Robertovna Klinov Dmitry Vladimirovich Bagrov Dmitry Vladimirovich 《Journal of biological physics》2021,47(2):205-214
Journal of Biological Physics - The morphology and proliferation of eukaryotic cells depend on their microenvironment. When electrospun mats are used as tissue engineering scaffolds, the local... 相似文献
5.
Arutjunyan Alexander V. Kerkeshko Gleb O. Milyutina Yuliya P. Shcherbitskaia Anastasiia D. Zalozniaia Irina V. 《Biochemistry. Biokhimii?a》2021,86(6):716-728
Biochemistry (Moscow) - The article presents current views on maternal hyperhomocysteinemia (HHcy) as an important factor causing prenatal stress and impaired nervous system development in fetuses... 相似文献
6.
Margarita A. Marchenkova Vladimir I. Timofeev Anastasiia S. Boikova Pavel V. Dorovatovskii Yulia A. Dyakova 《Journal of biomolecular structure & dynamics》2020,38(17):5159-5172
AbstractThe bonds between lysozyme molecules and precipitant ions in single crystals grown with chlorides of several metals are analysed on the basis of crystal structure data. Crystals of tetragonal hen egg lysozyme (HEWL) were grown with chlorides of several alkali and transition metals (LiCl, NaCl, KCl, NiCl2 and CuCl2) as precipitants and the three-dimensional structures were determined at 1.35?Å resolution by X-ray diffraction method. The positions of metal and chloride ions attached to the protein were located, divided into three groups and analysed. Some of them, in accordance with the recently proposed and experimentally confirmed crystal growth model, provide connections in protein dimers and octamers that are precursor clusters in the crystallization lysozyme solution. The first group, including Cu+2, Ni+2 and Na+1 cations, binds specifically to the protein molecule. The second group consists of metal and chloride ions bound inside the dimers and octamers. The third group of ions can participate in connections between the octamers that are suggested as building units during the crystal growth. The arrangement of chloride and metal ions associated with lysozyme molecule at all stages of the crystallization solution formation and crystal growth is discussed.Communicated by Ramaswamy H. Sarma 相似文献
7.
8.
Egor E. Diakonov Anastasiia V. Selenina Alexey N. Tomilin Anna S. Tsimokha 《Biochemical and biophysical research communications》2019,508(2):368-373
The ubiquitin proteasome system is involved in the regulation of most basic intracellular processes, and deregulation of this system can results in certain kinds of human diseases. Proteolytic core this system, the 20S proteasome, has been found in physiological fluids of both healthy humans and patients suffering from a variety of inflammatory, autoimmune, and neoplastic diseases. The concentration of these extracellular proteasomes has been found to correlate with the diseased state, being of a prognostic significance. The transport mechanisms and functions of these proteasomes, however, are largely unclear. Previous studies revealed that the transport of extracellular proteasomes may occur via microvesicles and exosomes, which led to the hypothesis that extracellular proteasomes are implicated in cell-to-cell communication process. Here we show that microvesicles and exosomes, two major known types of intercellular vehicles, contain no detectable proteasomes. Moreover, neither affinity purified nor naturally released into conditioned medium by donor cells 20S proteasomes could penetrate recipient HeLa cells. Taken together, these results suggest that extracellular proteasomes are unlikely to be involved in the cell-to-cell communication and that their release by cells serve other biological purposes. 相似文献
9.
10.
G. I. Lobov N. A. Shcherbakova R. M. Gorodnichev A. A. Grishin Y. P. Gerasimenko T. R. Moshonkina 《Human physiology》2017,43(5):518-523
Changes in the blood flow in the skin of the plantar surface of the hallux were investigated by laser Doppler flowmetry in eight healthy subjects during transcutaneous electrical spinal cord stimulation (tESCS) with the pulse parameters used to activate locomotion. Continuous tESCS in the area of C5–C6 vertebrae did not cause significant changes in the blood flow, while electrical stimulation at T 12–T 1 and L 1–L 2 levels resulted in an increase in skin perfusion by 22–27%. Wavelet analysis of microcirculatory fluctuations showed that tESCS induced flaxomotions in the range of sensory peptidergic fibers and enhanced the amplitude of fluctuations of microcirculation in the endothelium-dependent range. These results suggest that tESCS stimulates microcirculation in the skin mainly due to antidromic stimulation of sensory peptidergic nerve fibers, which promotes activity of microvascular endothelium, vasodilator secretion, a decrease in vascular resistance, and an increase in microcirculation. 相似文献