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注意缺损多动障碍关联于DXS7位点 总被引:5,自引:2,他引:3
用单细胞凝胶电泳法检测了稀土化合物氯化钇和氯化镨对人外周血淋巴细胞的DNA损伤效应。结果表明,与对照相比,3种不同浓度的氯化钇和氯化镨均可引起淋巴细胞DNA受损后DNA迁移率的显著升高,受损伤细胞的百分率与对照差异明显,提示氯化钇和氯化镨具有一定的遗传毒性。
Abstract:The effect of DNA damage in human lymphocytes induced by yttrium chloride and praseodymium chloride was detected using SCG assay.The results showed that a highly significant increase in DNA migration in DNA-damaged lymphocytes was induced by three different concentrations of yttrium and praseodymium compared with the control,The percentage of DNA-damaged have genetic toxicity.The relevant points to this study are discussed. 相似文献
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上海地区汉族人5-HT2a受体基因T102C多态性的基因频率分布 总被引:5,自引:0,他引:5
罗星光 江三多 江开达 顾牛范 林嗣萃 钱伊萍LUO Xing-guang JIANG San-duo JIANG Kai-da GU Niu-fan LIN Si-cui QIAN Yi-ping 《遗传》1998,20(5):25-27
为了揭示中国汉族人5-HT2a受体基因T102C多态性基因频率的分布,我们随机抽取了226例汉族健康人作研究,用限制性片段长度多态性(RFLPs)技术测定研究对象的基因型和等位基因。结果发现汉族正常人5-HT2a受体基因T102C多态性基因型频率依次为:A1/A2=0.5044,A1/A1=0.2965,A2/A2 =0.1991,两种等位基因频率依次为:A1=0.5487,A2=0.4513,杂合度H=0.50 44、期望杂合度h=0.4953,多态信息量PIC=0.3726,表明T102C多态性具有合适信息,对疾病的关联研究,法医学鉴定有一定的价值。
Abstract:To investigate the distribution about genotype and allele frequencies of T102C polymorphism in the 5-HT2a receptor gene Chinese Han population,the genotypes and alleles of 226 healthy person were examined with Restriction Fragment Length Polymorphisms(RFLPs)technique.The genotype frequencies are as follows:A1/A2=0.5044,A1/A1=0.2965,A2/A2=0.1991,respectively,and the allele frequencies are as follows:A1=0.5487,A2=0.4513,respectively.The heterozygosity(H)is 0.5044,the expected heterozygosity(h)is 0.4953,and the Polymorphism Information Content(PIC)is 0.3726.Our findings suggest that the T102C polymorphism in 5-HT2a receptor gene may have suitable information to be used for association study or forensic identification. 相似文献
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江三多 忻仁娥 林嗣萃 钱伊萍 江开达 任大明 汤国梅 汪栋祥 严和骏JIANG San-Duo)XIN Ren-E)LIN Si-Cui)QIAN Yi-Ping)JIANG Kai-Da)REN Da-Ming)TANG Guo-Mei)WANG Dong-Xang)YAN He-Jun) 《遗传》1999,21(2):7-615
采用单体型相对风险和传递/不平衡检验方法,在中国人群中对注意缺损多动障碍(ADHD)与DXS7位点进行了遗传关联分析。结果表明,以父母双亲为对照,DXS7位点157bp等位基因与ADHD具有显著关联(χ2=9.10, P<0.05)并连锁(χ2=9.53, P<0.05)。提示,ADHD关联和连锁于DXS7位点。
Abstract The present study was designed to assess the genetic association between attention-deficit hyperactivity disorder(ADHD) and DXD7 locus polymorphism in Chinese population, with haplotype-based haplotype relative risk(HHRR) and the transmission/disequilibrium test(TDT) analysis. We found significant association(χ2=9.10, P<0.05) and linkage (χ2=9.53, P<0.05) between the 157bp DXS7 allele and DSM-Ⅲ-R-diagnosed ADHD(N=54) in trios composed of father, mother and affected offspring. Our results suggest that ADHD was associated and in linkage with DXS7 locus. 相似文献
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两种构祀植物花药培养单倍体的诱导 总被引:3,自引:1,他引:2
对110例广东汉族人血清作了补体C2, Bf, C4的测定,其基因频率分V1为:C2*C'0.9500, C2*B:
0.0227,C2-,4:0182, C2*QO:O.0091;Bf*S:0.8364, Bf^`F:0.1409, Bf*S07:0.0091, Bf *S025:
0.009i,Bf*S055:0,0045; C4*A3:0.6327,C4*A4:0.1327,C4*_00:0.1020, C4*A5:0.0255 (一4*A2:
0·0918,C4*,41:0.0053;C4*B1:0.4569, C4*B2:0.4416, C4*QO:O.0558,C4*B5:0.0152,C4"}B96:
0.0152, C4*B3:0.0102, C4*B92:0.0051。木调查在我国首次发现一例C2*QO纯合子。 相似文献
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