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LEI P HE Y SHI W PENG J WU S ZHU H CHEN J SHEN G 《Acta biochimica et biophysica Sinica》2007,39(8):599-607
Myelosuppression is one of the major side-effects of most anticancer drugs. To achieve myeloprotection, one bicistronic vector encoding anti-apoptotic protein human WEE l (WEElHu) and proliferation-stimulating stem cell factor (SCF) was generated. In this study, we selected human umbilical cord blood CD34^+ cells as the in vitro model in an attempt to investigate whether WEEIHu, rather than conventional drug-resistant genes, can be introduced to rescue cells from the damage by chemotherapeutic agents such as cisplatin, adriamycin, mitomycin-c and 5-fluorouracil. Cell viability and cytotoxicity assay, colony-forming units in culture assay and externalization of phospholipid phosphatidylserine analysis showed that the expression of WEElHu and SCF in CD34^+ cells provided the cells with some protection. These findings suggest that the expression of WEElHu and SCF might rescue CD34^+ cells from chemotherapyinduced myelosuppression. 相似文献
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ZHANG Wei FENG Jiannan & SHEN Beifen Beijing Basic Medical Institute Beijing China 《中国科学:生命科学英文版》2004,(3)
Humantumornecrosisfactor-a(hTNF-a)isanunglycosylated,pleiotropiccytokinewithnumerousbiologicaleffectsincludingcytotoxicandproinflam-matoryactivities[1].Asrevealedbytheresearchwithmurinemodel,hTNF-playedakeyroleinmanydis-easessuchasrheumatoidarthritis,multiplesclerosisandinflammatoryboweldisease[2],andtherefore,be-cameausefultargetoftherapyforthediseases.Neu-tralizingmonoclonalantibody(mAb)againsthTNF-,asanagentblockinghTNF-activity,hasbeenusedfortherapyofthosediseasesabove[3,4].ThemAb,de… 相似文献
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LI Zhengxi Jing-Jiang ZHOU SHEN Zuorui & Lin FIELD .Department of Entomology China Agricultural Univeristy Beijing China .Biological Chemistry Division Rothamsted Research Harpenden Herts. AL JQ UK Correspondence should be addressed to Li Zhengxi 《中国科学:生命科学英文版》2004,47(6):567-576
~~Identification and expression profiling of putative odorant-binding proteins in the malaria mosquitoes, Anopheles gambiae and A. arabiensis1. Curtis, C. F., Introduction 1: An overview of mosquito biology, behaviour and importance, in Olfaction in Mosquito-Host Interactions (eds. Bock, G. R.. Cardew, G.), New York: Wiley, 1996, 3-7.
2. Nighom, A., Hildebrand. J. G.. Dissecting the molecular mechanisms of olfaction in a malaria-vector mosquito, PNAS, 2002, 99(3): 1113-… 相似文献
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Trichosanthin inhibits T cell activation by interfering with the recruitment of ZAP-70 to CD3 ζchain
INTRoDUCTIONThichosanthin(Tk),aplantproteinisolatedfromaChinesemedicinalherbTh-1.Correspondenceaddress:Dr.KuangYenCHoU,ShanghaiInstituteofImmunology,Shang-haiSecondMedicalUniversity28oSouthChongqingRoad,Shanghai2ooo25,China.Fax:(8621)63846383,E-mail:my@sh… 相似文献
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转基因植物生产动物疫苗的研究及应用 总被引:6,自引:0,他引:6
转基因植物生产动物疫苗的研究及应用范国昌1,2山松1钱凯先2沈桂芳1(1.中国农业科学院生物技术研究中心,北京100081)(2.浙江大学生物科学与技术系,杭州310027)ResearchandApplicationonTransgenicPlan... 相似文献