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Wang Xin Dong Chunxiao Zhou Qingjun Duan Haoyun Zou Dulei Gong Yajie Ma Bochao Li Zongyi Shi Weiyun 《Apoptosis : an international journal on programmed cell death》2021,26(11-12):600-611
Apoptosis - Fuchs endothelial corneal dystrophy (FECD) is one of the main causes for corneal endothelial blindness, which is characterized by the progressive decline of corneal endothelial cells.... 相似文献
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Jiugang Zhao Xi Long Yihuan Yang Hongmei Pan Liang Zhang Zongyi Guo 《Animal biotechnology》2013,24(4):302-310
AbstractThe immunophilins are an important group of regulatory molecules in the immune system. FKBP5, expressed throughout mammals and in fish and birds, functions in both physiological and pathogenic pathways, including innate immunity and steroid-based diseases. In this study, we cloned the first porcine FKBP5 from Rongchang pig by the rapid amplification of cDNA ends technique. The full-length cDNA is 4097?bp, with an open reading frame of 1371?bp that codes for a 457-aa protein. Western blotting detected the porcine FKBP5 protein at highest levels in thymus, followed by spleen and lung. Immunohistochemistry detected the porcine FKBP5 protein in lymphocytes and granulocytes of the blood, and flow cytometry identified greater expression in unactivated (vs. activated) T lymphocytes. Finally, the expression level of porcine FKBP5 in the granulocytes was found to decline significantly from the time of birth to one-year-old. These collective data suggest that the newly identified porcine FKBP5 may function in activation of T cells in pig and in innate immunity in the newborn pig in particular. 相似文献
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刺槐花叶病是我国北方刺槐(Robiniapseudoacacia)常见病害。1987~1995年对河南、河北、山东和北京部分地区刺槐进行调查,刺槐花叶病发病率为4%~87.5%。该病害主要特征是:叶片出现浅绿与绿色相间带有疱疹的花叶症状,叶缘波状扭... 相似文献
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EktacytometrymeasuringRBCdeformabilitywasfirstdevelopedbyBessisetal.in1975[1].Thistechniquehasbeenworldwideacceptednow.However,themeaningofdeformationindex(DI)measuredwiththismethodisstillworthstudying.ThetraditionalEktacytometryusessuspendingmediumofhighvi… 相似文献
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Zeissig S Murata K Sweet L Publicover J Hu Z Kaser A Bosse E Iqbal J Hussain MM Balschun K Röcken C Arlt A Günther R Hampe J Schreiber S Baron JL Moody DB Liang TJ Blumberg RS 《Nature medicine》2012,18(7):1060-1068
In most adult humans, hepatitis B is a self-limiting disease leading to life-long protective immunity, which is the consequence of a robust adaptive immune response occurring weeks after hepatitis B virus (HBV) infection. Notably, HBV-specific T cells can be detected shortly after infection, but the mechanisms underlying this early immune priming and its consequences for subsequent control of viral replication are poorly understood. Using primary human and mouse hepatocytes and mouse models of transgenic and adenoviral HBV expression, we show that HBV-expressing hepatocytes produce endoplasmic reticulum (ER)-associated endogenous antigenic lipids including lysophospholipids that are generated by HBV-induced secretory phospholipases and that lead to activation of natural killer T (NKT) cells. The absence of NKT cells or CD1d or a defect in ER-associated transfer of lipids onto CD1d results in diminished HBV-specific T and B cell responses and delayed viral control in mice. NKT cells may therefore contribute to control of HBV infection through sensing of HBV-induced modified self-lipids. 相似文献
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Splenic erythroblasts were obtained from mice during the acute disease caused by anemia-inducing virus (FVA). They were cultured in a medium containing EPO, BSA and so on. We studied their biomechanical and hemorheological behavior after 12 h, 24 h and 48 h. The results showed obvious changes in their electrophoretic mobility, osmotic fragility, membrane fluidity and membrane viscoelastic properties with the development of erythroblast. The changes were associated with the interactions of the protein and lipid and the elements of the membrane. 相似文献
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