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Albert Zlatkis Colin F. Poole Roswitha Brazeli Donald A. Bafus Peter S. Spencer 《Journal of chromatography. B, Analytical technologies in the biomedical and life sciences》1980,182(2):137-145
The profiles of volatile metabolites in serum samples from normal individuals and from individuals with diabetes mellitus with varying degrees of polyneuropathy have been studied. The transevaporator procedure was used to obtain sample extracts which were chromatographed on a highly efficient glass column coated with Silar 10C (106 m × 0.25 mm I.D.). Differences in profiles between normal subjects and diabetic subjects on no drug therapy were noticed. However, correlations between the severity of the neuropathy and the concentrations of certain ketones could not be established. Compounds present both in diabetic and normal sera have been identified by mass spectrometry. 相似文献
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S. Singhawangcha C. F. Poole A. Zlatkis 《Journal of chromatography. B, Analytical technologies in the biomedical and life sciences》1980,183(4)
Guaifenesin after extraction from plasma with an organic solvent can be selectively derivatized with 2,4-dichlorobenzeneboronic acid and determined by gas chromatography with electron-capture detection. The detection limit for guaifenesin was 15 ng ml−1 for a 2.0-ml plasma sample. The mass spectra of the boronate derivatives of guaifenesin and mephenesin, used as internal standard, show good molecular ions with characteristic modes of fragmentation useful for their identification. 相似文献
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Study of a new cholesterol reagent 总被引:19,自引:0,他引:19
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Albert Zlatkis Kwan Young Lee Colin F. Poole Gunther Holzer 《Journal of chromatography. B, Analytical technologies in the biomedical and life sciences》1979,163(2):125-133
Using a transevaporator sampling technique, the volatile profiles from 70 μl of serum were obtained by capillary-column gas chromatography. The complex chromatograms were interpreted by a combination of manual and computer techniques and a two-peak ratio method devised for the classification of normal and virus-infected sera. Using the K-nearest neighbor approach 85.7% of teh unknown samples were classified correctly. Some preliminary results indicate the possible use of the method for the assessment of virus susceptibility. 相似文献
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