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Ma Bohan Liu Zhanzhu Yan Wei Wang Lixue He Haobo Zhang Aijing Li Zeyuan Zhao Qiuzhu Liu Mingming Guan Shuyan Liu Siyan Qu Jing Yao Dan Zhang Jun 《Functional & integrative genomics》2021,21(3):435-450
Functional & Integrative Genomics - Soybean oil is composed of fatty acids and glycerol. The content and composition of fatty acids partly determine the quality of soybean seeds. Circular RNAs... 相似文献
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Xuan Pan Lulu Tao Ming Ji Xiaoguang Chen Zhanzhu Liu 《Bioorganic & medicinal chemistry letters》2018,28(5):866-868
A series of novel imidazo[4,5-d]azepine compounds derived from marine natural product ceratamine A were designed and synthesized in 7 steps. Most compounds exhibited comparable cytotoxicity against five human cancer cell lines (HCT-116, HepG2, BGC-823, A549 and A2780) to natural product ceratamine A. Compound 1k, bearing methoxy group at C-14, C-15 and C-16, showed the best in vitro cytotoxicity, which was better than ceratamine A. The structure and activity relationships study showed that the benzyloxymethyl group on N-3 played an important role on the cytotoxicity. 相似文献
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Zhaozhu Sun Tian Zhou Xuan Pan Ying Yang Yi Huan Zhiyan Xiao Zhufang Shen Zhanzhu Liu 《Bioorganic & medicinal chemistry letters》2018,28(18):3050-3056
A novel series of GPR40 agonists is designed by introducing nitrogen-containing heterocyclic ring at the terminal phenyl ring of TAK-875 with the aim of decreasing its lipophilicity. Three different β-substituted phenylpropionic acids were investigated as the acidic components. A total of 34 compounds have been synthesized, among which, compound 30 exhibited comparable GPR40 agonistic activity in vitro with TAK-875 and relatively lower lipophilicity through calculation (30, EC50?=?1.2?μM, cLogP?=?1.3; TAK-875: EC50?=?5.1?μM, cLogP?=?3.4). Moreover, compound 30 was able to enhance the insulin secretion of primary islets isolated from normal ICR mice and showed no obvious inhibition against cytochromes P450 in vitro. In vivo, compound 30 exhibited efficacy in oral glucose tolerance test (oGTT) in normal ICR mice. 相似文献
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Liu W Dong W Liao X Yan Z Guan B Wang N Liu Z 《Bioorganic & medicinal chemistry letters》2011,21(5):1419-1421
(−)-Renieramycin G and fifteen C-22 analogs were prepared employing l-tyrosine as the chiral starting material. These analogs, along with (−)-renieramycin G itself, were evaluated in vitro for cytotoxicity against HCT-8, BEL-7402, A2780, MCF-7, A549, BGC-823, Ketr3, KB, Hela cells. The IC50 values of most of these analogs were at the level of μM. Among these analogs, 2-thiophenecarboxylate ester derivative 17 exhibited potent cytotoxic activity against KB cell line with the IC50 of 20 nM. From this study, it could be concluded that the C-22 side chain played an important role in the cytotoxic potency and specificity of this class of (−)-renieramycin G derivatives. 相似文献
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