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Deng Wu Yunao Liu Wei Chen Jianming Shao Pubu Zhuoma Dexiong Zhao Yang Yu Tianzi Liu Ruoxuan Yu Yongna Gan Baima Yuzheng Yongshu Huang Haikun Zhang Xiaoman Bi Chengcheng Tao Shujuan Lai Qiaoxia Luo Dake Zhang Hongmei Wang Pingcuo Zhaxi Jianqing Zhang Jie Qiao Changqing Zeng 《Molecular biology and evolution》2022,39(6)
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Qiu‐mei Ji Jin‐wei Xin Zhi‐xin Chai Cheng‐fu Zhang Yangla Dawa Sang Luo Qiang Zhang Zhandui Pingcuo Min‐Sheng Peng Yong Zhu Han‐wen Cao Hui Wang Jian‐lin Han Jin‐cheng Zhong 《Molecular ecology resources》2021,21(1):201-211
Yak is an important livestock animal for the people indigenous to the harsh, oxygen‐limited Qinghai‐Tibetan Plateau and Hindu Kush ranges of the Himalayas. The yak genome was sequenced in 2012, but its assembly was fragmented because of the inherent limitations of the Illumina sequencing technology used to analyse it. An accurate and complete reference genome is essential for the study of genetic variations in this species. Long‐read sequences are more complete than their short‐read counterparts and have been successfully applied towards high‐quality genome assembly for various species. In this study, we present a high‐quality chromosome‐scale yak genome assembly (BosGru_PB_v1.0) constructed with long‐read sequencing and chromatin interaction technologies. Compared to an existing yak genome assembly (BosGru_v2.0), BosGru_PB_v1.0 shows substantially improved chromosome sequence continuity, reduced repetitive structure ambiguity, and gene model completeness. To characterize genetic variation in yak, we generated de novo genome assemblies based on Illumina short reads for seven recognized domestic yak breeds in Tibet and Sichuan and one wild yak from Hoh Xil. We compared these eight assemblies to the BosGru_PB_v1.0 genome, obtained a comprehensive map of yak genetic diversity at the whole‐genome level, and identified several protein‐coding genes absent from the BosGru_PB_v1.0 assembly. Despite the genetic bottleneck experienced by wild yak, their diversity was nonetheless higher than that of domestic yak. Here, we identified breed‐specific sequences and genes by whole‐genome alignment, which may facilitate yak breed identification. 相似文献
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