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Sadegh Fattahi Mohadeseh Kosari-Monfared Monireh Golpour Zakieh Emami Mohammad Ghasemiyan Maryam Nouri Haleh Akhavan-Niaki 《Journal of cellular physiology》2020,235(4):3189-3206
Gastric cancer is the third leading cause of cancer death with 5-year survival rate of about 30–35%. Since early detection is associated with decreased mortality, identification of novel biomarkers for early diagnosis and proper management of patients with the best response to therapy is urgently needed. Long noncoding RNAs (lncRNAs) due to their high specificity, easy accessibility in a noninvasive manner, as well as their aberrant expression under different pathological and physiological conditions, have received a great attention as potential diagnostic, prognostic, or predictive biomarkers. They may also serve as targets for treating gastric cancer. In this review, we highlighted the role of lncRNAs as tumor suppressors or oncogenes that make them potential biomarkers for the diagnosis and prognosis of gastric cancer. Relatively, lncRNAs such as H19, HOTAIR, UCA1, PVT1, tissue differentiation-inducing nonprotein coding, and LINC00152 could be potential diagnostic and prognostic markers in patients with gastric cancer. Also, the impact of lncRNAs such as ecCEBPA, MLK7-AS1, TUG1, HOXA11-AS, GAPLINC, LEIGC, multidrug resistance-related and upregulated lncRNA, PVT1 on gastric cancer epigenetic and drug resistance as well as their potential as therapeutic targets for personalized medicine was discussed. 相似文献
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Shadi Eshghi Sahraei Brendan Furneaux Kerri Kluting Mustafa Zakieh Hkan Rydin Hkan Hytteborn Anna Rosling 《Ecology and evolution》2022,12(3)
Long amplicon metabarcoding has opened the door for phylogenetic analysis of the largely unknown communities of microeukaryotes in soil. Here, we amplified and sequenced the ITS and LSU regions of the rDNA operon (around 1500 bp) from grassland soils using PacBio SMRT sequencing. We tested how three different methods for generation of operational taxonomic units (OTUs) effected estimated richness and identified taxa, and how well large‐scale ecological patterns associated with shifting environmental conditions were recovered in data from the three methods. The field site at Kungsängen Nature Reserve has drawn frequent visitors since Linnaeus''s time, and its species rich vegetation includes the largest population of Fritillaria meleagris in Sweden. To test the effect of different OTU generation methods, we sampled soils across an abrupt moisture transition that divides the meadow community into a Carex acuta dominated plant community with low species richness in the wetter part, which is visually distinct from the mesic‐dry part that has a species rich grass‐dominated plant community including a high frequency of F. meleagris. We used the moisture and plant community transition as a framework to investigate how detected belowground microeukaryotic community composition was influenced by OTU generation methods. Soil communities in both moisture regimes were dominated by protists, a large fraction of which were taxonomically assigned to Ciliophora (Alveolata) while 30%–40% of all reads were assigned to kingdom Fungi. Ecological patterns were consistently recovered irrespective of OTU generation method used. However, different methods strongly affect richness estimates and the taxonomic and phylogenetic resolution of the characterized community with implications for how well members of the microeukaryotic communities can be recognized in the data. 相似文献
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Nazari Soltan Ahmad Saeed Kalantary-Charvadeh Ashkan Hamzavi Masoud Ezzatifar Fatemeh Aboutalebi Vand Beilankouhi Elmira Toofani-Milani Attabak Geravand Faezeh Golshadi Zakieh Mesgari-Abbasi Mehran 《Journal of molecular histology》2022,53(4):691-698
Journal of Molecular Histology - Renal fibrosis is characterized by accumulation of extracellular matrix components and collagen deposition. TGF-β1 acts as a master switch promoting renal... 相似文献
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Karimi Farzaneh Amiri-Moghaddam Seyedeh Mina Bagheri Zakieh Bahrami Ahmad Reza Goshayeshi Ladan Allahyari Abolghasem Mirsadraee Marjane Fanipakdel Azar Bari Alireza Emadi-Torghabeh Ali Kerachian Mohammad Amin Rahimi Hossein Matin Maryam M. 《Molecular biology reports》2021,48(3):2273-2284
Molecular Biology Reports - Genome-wide association studies have revealed that some single nucleotide polymorphisms at 8q24, such as rs6983267, might be effective in susceptibility to various... 相似文献
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