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Naw Hser Gay Kamonrat Phopin Wilasinee Suwanjang Napat Songtawee Waralee Ruankham Prapimpun Wongchitrat Supaluk Prachayasittikul Virapong Prachayasittikul 《Neurochemical research》2018,43(3):619-636
An increase in oxidative stress is a key factor responsible for neurotoxicity induction and cell death leading to neurodegenerative diseases including Parkinson’s and Alzheimer’s diseases. Plant phenolics exert diverse bioactivities i.e., antioxidant, anti-inflammatory, and neuroprotective effects. Herein, phenolic compounds, namely protocatechuic aldehyde (PCA) constituents of Hydnophytum formicarum Jack. including vanillic acid (VA) and trans-ferulic acid (FA) found in Spilanthes acmella Murr., were explored for anti-neurodegenerative properties using an in vitro model of oxidative stress-induced neuroblastoma SH-SY5Y cells. Exposure of the neuronal cells with H2O2 resulted in the decrease of cell viability, but increasing in the level of reactive oxygen species (ROS) together with morphological changes and inducing cellular apoptosis. SH-SY5Y cells pretreated with 5 µM of PCA, VA, and FA were able to attenuate cell death caused by H2O2-induced toxicity, as well as decreased ROS level and apoptotic cells after 24 h of treatment. Pretreated SH-SY5Y cells with phenolic compounds also helped to upregulate H2O2-induced depletion of the expressions of sirtuin-1 (SIRT1) and forkhead box O (FoxO) 3a as well as induce the levels of antioxidant (superoxide dismutase (SOD) 2 and catalase) and antiapoptotic B-cell lymphoma 2 (Bcl-2) proteins. The findings suggest that these phenolics might be promising compounds against neurodegeneration. 相似文献
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Shukla Mayuri Wongchitrat Prapimpun Govitrapong Piyarat 《Neurochemical research》2022,47(5):1166-1182
Neurochemical Research - Numerous challenges are confronted when it comes to the recognition of therapeutic agents for treating complex neurodegenerative diseases like Alzheimer’s disease... 相似文献
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Nopparat Chutikorn Chaopae Worawut Boontem Parichart Sopha Pattarawut Wongchitrat Prapimpun Govitrapong Piyarat 《Neurochemical research》2022,47(9):2568-2579
Neurochemical Research - Diabetes mellitus (DM), one of metabolic diseases, has been suggested as a risk factor for Alzheimer’s disease (AD). However, how the metabolic pathway activates... 相似文献
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