Similar hypotensive responses to resistance exercise with and without blood flow restriction

Low intensity resistance exercise (RE) with blood flow restriction (BFR) has gained attention in the literature due to the beneficial effects on functional and morphological variables, similar to those observed during traditional RE without BFR, while the effects of BFR on post-exercise hypotension remain unclear. The aim of the present study was to compare the blood pressure (BP) response of trained normotensive individuals to RE with and without BFR. In this cross-over randomized trial, eight male subjects (23.8 ± 4 years, 74 ± 3 kg, 174 ± 4 cm) completed two exercise protocols: traditional RE (3 x 10 repetitions at 70% one-repetition maximum [1-RM]) and low intensity RE (3 x 15 repetitions at 20% 1-RM) with BFR. Blood pressure measurements were performed after 15 min of seated rest (0), immediately after and 10 min, 20 min, 30 min, 40 min, 50 min and 60 min after the experimental sessions. Similar hypotensive effects for systolic BP (SBP) were observed for both protocols (P < 0.05) after exercise, with no differences between groups (P > 0.05) and no statistically significant difference for diastolic BP (P > 0.05). These results suggest that in normotensive trained individuals, both traditional RE and RE with BFR induce hypotension for SBP, which is important to prevent cardiovascular disturbances.     

小鼠负重游泳后血清代谢模式变化分析

目的：研究小鼠负重游泳导致疲劳过程中血清代谢模式改变,为营养抗疲劳研究提供依据。方法：雄性昆明小鼠,随机分为4组,以AIN-93饲料喂养14 d,分别接受0（正常对照）、30、601、20 min等不同时间的尾部负重游泳,游泳后处死小鼠,分离血清进行代谢组分析。采用驰豫编辑脉冲序列（CPMG）和扩散编辑脉冲序列（LED）采集血清样本的数据,经傅立叶变换得到1H NMR谱图,SIMCA-P＋软件进行主成分分析。结果：游泳后小鼠血清代谢组发生显著改变,较正常对照组升高的化合物有β-羟基丁酸、乙酸、乳酸、脂类物质等,降低的化合物有葡萄糖、胆碱、磷酸胆碱、丙氨酸、磷脂酰胆碱等,随游泳时间延长变化趋势相应逐渐增大。结论：小鼠游泳后血清代谢模式产生一些规律性变化,其中脂肪代谢相关物质变化较为显著,针对胆碱类物质在脂肪代谢中的作用开展研究对于揭示疲劳过程本质及其机制具有一定意义。