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Waya S. Phutdhawong Wanwikar Ruensamran Weerachai Phutdhawong Thongchai Taechowisan 《Bioorganic & medicinal chemistry letters》2009,19(19):5753-5756
A rapid route to a series of naphthoquinone-fused indole derivatives via irradiation in a modified commercial domestic microwave is reported. The desired products were produced in high yields and short reaction times. The naphthoquinone-fused indole derivatives were evaluated for their pro-inflammatory cytokines responses using lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. The results showed that most of the tested compounds inhibit the production of nitric oxide (NO), prostaglandin (PG)E2, tumour necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β in RAW264.7 cells treated with LPS. 相似文献
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