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排序方式: 共有112条查询结果,搜索用时 31 毫秒
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EA Dukhanina TI Lukyanova EA Romanova V Guerriero NV Gnuchev GP Georgiev DV Yashin LP Sashchenko 《Cell cycle (Georgetown, Tex.)》2015,14(22):3635-3643
PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7–Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4+ and CD8+ lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response. 相似文献
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N N Vorontsov 《Zhurnal obshche? biologii》1989,50(6):737-745
Unjustified narrowing of the problems of morphology by merging the terms "morphology" and "anatomy" leads to stagnation in morphology. The merging of "classic" and "modern" biology will enrich both morphology and molecular biology and genetics. The latter will be able apply conceptual models of morphology to more primitive structural level of life. The possibility to apply V. A. Dogel' 's ideas on the role of oligomerization and polymerization in science to the analysis of molecular evolution has been demonstrated with the analysis of DNA content in the genomes of Chordata taken as an example. The data on DNA content do not allow both to consider lungfishes as ancestors of all Tetrapoda and develop monophyletic concept of Tetrapoda origin at the same time. The possibility of application of concepts of comparative morphology to analysis of molecular evolution has been considered. 相似文献
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D I Levitski? A F Rusak N L Kashtanova E D Vorontsov V P Ebdakov 《Biokhimii?a (Moscow, Russia)》1979,44(9):1721-1724
Isolated myosin heads (HMM-S1) were concentrated by ultrafiltration in an "Amicon" cell to a concentration of 120 mg/ml. Incubation of HMM-S1 with ATP in the presence of Mg2+ produced an AMP peak in the spectrum of NMR-31P whose size was increasing linearly with the reaction time. It was demonstrated that after heating of the sample the appearance of AMP in the incubation mixture was due to the presence of a small amount of adenylate kinase (or myokinase) in the purified preparation of HMM-S1. 相似文献
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29 individuals of Apodemus peninsulae, an Asian forest mouse from the Suputin State Nature Reserve (Maritime Territory) were studied karyologically. Diploid chromosome sets of the animals studied contained from 48 to 52 chromosomes. The difference in the diploid chromosome numbers is caused by the presence in some individuals of supernumerary metacentric chromosomes (up to 4). The set is always represented by 48 acrocentric chromosomes, gradually decreasing in size. The supernumerary metacentric chromosomes vary in size from medium-sized to the smallest in the set. The character of intrapopulational chromosome polymorphism of continental and island populations of Apodemus peninsulae is discussed. Attempts are made to explain the polymorphism with respect to supernumerary chromosomes as the result of some viral diseases. 相似文献
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N. G. Yabbarov G. A. Posypanova E. A. Vorontsov O. N. Popova E. S. Severin 《Biochemistry. Biokhimii?a》2013,78(8):884-894
Polyamidoamine (PAMAM) dendrimers of the second generation (G2) are branched polymers containing 16 surface amino groups that allow them to be used as universal carriers on creating systems for drug delivery. G2 labeled with fluorescein isothiocyanate (FITC) efficiently bound with the surface of tumor cells at 4°C and was absorbed by the cells at 37°C. The covalent binding to G2-FITC of a vector protein, a recombinant fragment of the human alpha-fetoprotein receptor-binding domain (rAFP3D), increased the binding and endocytosis efficiency more than threefold. Covalent conjugates of G2 with doxorubicin (Dox) obtained by acid-labile linking of cis-aconitic anhydride (CAA) without the vector protein (G2-Dox) and with the vector protein rAFP3D (rAFP3D-G2-Dox) were accumulated by the tumor cells with high efficiency. However, a selective effect was observed only in rAFP3D-G2-Dox, which also demonstrated high cytotoxic activity against the human ovarian adenocarcinoma SKOV3 cells and low cytotoxicity against human peripheral blood lymphocytes. Based on these results, rAFP3D-G2 conjugate is promising for selective delivery of antitumor drugs. 相似文献
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Saukhat SR Vorontsov DV Tormozova NM Golubenko IA Kravchenko VF Poplavskaia TK Ternovaia NM Rabinovich VD Orlov NV Ryndich IV Prokopenkova SA 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2000,(4):89-92
The necessity and effectiveness of introducing the program of the exchange of syringes for intravenous drug users as a preventive and antiepidemic measure are discussed. Preventive and antiepidemic measures within the concept of harm reduction are described. The comparative analysis of materials obtained as a result of two sociological questionings, carried out in 1997-1998 among the representatives of the community (random nonrepeating choice) and in the middle of 1999 among the participants of the program revealed that the participants of the program had statistically significant changes in risky behavior patterns during the use of injection drugs. 相似文献