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Ranbir Chander Sobti Nega Berhane Salih Abedule Mehedi Rupinder Kler Seyed Ali Hosseini Vijish Kuttiat Ajay Wanchu 《Molecular biology reports》2010,37(1):317-324
Various efforts made to stop the deadly epidemic of HIV since its discovery in 1983 remain unsuccessful and this virus still
continues to claim the lives of millions of individuals every year. The viral effect in the cell is complicated and the overall
disease outcome is the result of interaction between a few viral proteins and complex host immune response. Because it has
been reported that XPG (Xeroderma pigementesum group G) gene does play a role in reducing UV induced apoptosis and participate in Nucleotide Excision
Repair (NER) process of DNA damage, it was hypothesized that polymorphism in this gene may have a role in HIV 1 disease progression
to AIDS. The aim of the present study, therefore, was to find out the association between XPG gene polymorphism and its effect on the rate of HIV 1 disease progression to AIDS. 300 HIV seropositive cases and an equal
number of age and sex matched controls were recruited for the study from north Indian population. The PCR-RFLP method was
utilized to genotype 600 study subject for the XPG Asp
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His gene polymorphism. There was significant difference in the frequency of the His/His variant genotype (OR 1.95, 95% CI = 1.93–3.63, P = 0.04) between cases and controls indicating a probable role of this gene in host viral interactions. 相似文献
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Ranbir Chander Sobti Nega Berhane Salih Abdul Mahdi Rupinder Kler Seyed Ali Hosseini Vijish Kuttiat Ajay Wanchu 《Molecular biology reports》2011,38(5):2945-2952
HIV/AIDS remains to be one of the killing diseases of mankind. Host genetic response is one of the factor which determine
susceptibility to HIV and disease progression to AIDS. The aim of the present study was to evaluate the impact of ERCC2
Lyc
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Gln (excision repair cross complementing rodent repair deficiency, complementation group 2) polymorphism on HIV-1 susceptibility
and disease progression to AIDS, as this gene has been reported to intervene in degrading retroviral cDNA before it integrates
with the host DNA. This case control study included 300 HIV seropositive cases and an equal number of HIV seronegative controls.
DNA was isolated from the blood samples of study subjects and genotyping of ERCC2 was conducted by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) method. The Gln/Gln genotype showed a significant variation between cases and controls (P = 0.047, OR 1.71, 95% CI 1.00–2.93), indicating a possible role of susceptibility in reference to controls and disease progression
when compared within cases. 相似文献
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Ranbir Chander Sobti Nega Berhane Salih Abdul Mahedi Rupinder Kler Seyed Ali Hosseini Vijish Kuttiat Ajay Wanchu 《Molecular and cellular biochemistry》2010,337(1-2):145-152
A growing body of evidence suggests that host genetic factors play an important role both in susceptibility to HIV infection and progression to AIDS. The present study aimed at evaluating the role of IL-6 and IL-10 gene polymorphisms on the risk of HIV susceptibility and disease progression among North Indian patients. The polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques were applied to genotype IL-6 and IL-10. 300 seropositive and an equal number of age- and sex-matched seronegative control subjects were recruited for this study. There was statistically no significant variation in the frequencies of IL-6 and IL-10 genotypes among cases and controls. However, statistically non-significant association for risk of rapid disease progression was observed due to the combined effect of the IL-6 homozygous CC genotype and CC of IL-10, OR = 1.62, 95% CI = 0.38–6.91. Therefore, combined effects of the CC of IL-6 and CC of IL-10 might reduce the hosts ability to hinder viral replication after infection. 相似文献
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