排序方式: 共有4条查询结果,搜索用时 15 毫秒
1
1.
2.
3.
Rajalingam R Du Z Meenagh A Luo L Kavitha VJ Pavithra-Arulvani R Vidhyalakshmi A Sharma SK Balazs I Reed EF Pitchappan RM Middleton D 《Immunogenetics》2008,60(5):207-217
By interacting with polymorphic HLA class I molecules, the killer cell immunoglobulin-like receptors (KIR) influence the innate
and adaptive immune response to infection. The KIR family varies in gene content and sequence polymorphism, thereby, distinguishing individuals and populations. To investigate
KIR diversity in the earliest settlers of India, we have characterized the KIR gene content in three Dravidian-speaking populations (Mollukurumba, Kanikar, and Paravar) from the state of Tamil Nadu, southern
India. The activating KIR genes and putative group-B KIR haplotypes were frequent in Paravar and Kanikar, a scenario analogous to those seen previously in other populations of Indian
origin, indicating that predominance of group-B KIR haplotypes is the characteristic feature of Indian populations. In contrast, the KIR gene profile of Mollukurumba was more related to Caucasian type. It is not clear whether a local-specific selection or a
recent admixture from Iran is responsible for such discrete profile in Mollukurumba. Each southern Indian population had distinct
KIR genotype profile. Comparative analyses with world populations revealed that group-B KIR haplotypes were frequent in the natives of India, Australia, and America, the populations associated with those involved
in extensive prehistoric human migrations. Whether or not natural selection has acted to enrich group-B KIR haplotypes in these migratory descendants is an issue that requires objective testing.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
4.
Govindaraj Krishnaveni Samayanpaulraj Vignesh Narayanadoss Vidhyalakshmi Uthandakalaipandian Ramesh 《Probiotics and antimicrobial proteins》2021,13(6):1598-1610
Probiotics and Antimicrobial Proteins - Probiotics play significant roles in enhancing systemic immunity, improving intestinal balance and feed value, enhancing enzymatic digestion, and inhibiting... 相似文献
1