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Veerabrahmam Alugolu Satyanarayana Rentala Aruna Lakshmi Komarraju Uma Devi Parimi 《Bioinformation》2013,9(7):334-338
Piperine, a major constituent of Piper nigrum (Black pepper), is one of the well known components in many Ayurvedic
formulations. Piperine is most studied bioenhancer because it inhibits drug metabolizing enzymes in rodents and increases plasma
concentrations of several drugs, including P-glycoprotein substrates. However, there areno evidences on piperine-iron conjugate to
inhibit human CYP450 3A4. We therefore investigated the influence of piperine-Fe conjugate to study the metabolism of iron with
CYP450 3A4. Our in silico results showed that Piperine when conjugated with iron, inhibited activity of CYP450 3A4. This
improved the binding of piperine-Fe conjugate with CYP450 3A4 and increased bioavailability. 相似文献
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