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Rotas G Natchkebia K Natsvlishvili N Kekelidze M Kimbaris A Varvounis G Mikeladze D 《Bioorganic & medicinal chemistry letters》2005,15(13):3220-3223
We have designed and synthesized several structural isomers of anthramycin (heterocycles 2, 3, 5, 6, and 8) and found that, in particular, pyrrolobenzodiazepine 8 induces DNA cleavage and formation of small fragments of DNA. The cytotoxic effects of 8 were manifested with both non-transformed primary neuronal/glial cells and transformed Jurkat cells. The other compounds did not change the viability either of transformed or of non-transformed cells, and induced DNA cleavage to a lesser extent. 相似文献
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Magafa Vassiliki Matsoukas Minos-Timotheos Karageorgos Vlasios Dermitzaki Eirini Exarchakou Revekka Stylos Evgenios Κ. Pardalos Michail Margioris Andrew N. Varvounis George Tzakos Andreas G. Spyroulias Georgios A. Liapakis George 《Amino acids》2019,51(7):1009-1022
Amino Acids - Neurotensin (NT) (pGlu–Leu–Tyr–Glu–Asn–Lys–Pro–Arg–Arg–Pro–Tyr–Ile–Leu) exerts a dual function as a... 相似文献
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