The differentiation of rhythmogenic characteristics of the ureter's different regions in guinea pigs

Characteristics of rhythmogenic pacemakers of the ureter's perirenal middle and peribladder region morphologically and electrophysiologically are analysed in guinea pigs both in presence of spreading activity and breach of conductivity. It was shown that the action potential's amplitude of the middle region is the highest and duration of the spike activities from perirenal zone is maximal and all three regions are characterised by different functional conditions.     

Effect of histamine on spontaneous rhythmogenesis of the guinea pig ureter

Histamine changed characteristics of the perinephric spontaneous spike activity and of the spreading electrical wave. It was shown that histamine could activate latent pacemakers of the ureter's middle area. Morphological picture of the histamine effect was also shown.     

Activation of latent pacemakers in the guinea pig ureter

Guinea pig's ureter rhythmogenic autonomous latent pacemaker was shown to generate a significantly higher-frequency rhythm than the pericystic pacemaker. The latent pacemakers of the ureter middle portion can be activated with a breach of electrical conductivity across the organ or with chemical agents (noradrenaline, histamine).     

Effect of dimedrol on the regulation by histamine of the pacemaker activity of the cat ureter

A certain concentration of Dimedrol (0.5 x 10(-6) mol/l) turned out to be capable of neutralising the histamine regulation of the slow-wave activity. The histamine H1-receptors were shown to modulate the cat general pace-maker's activity as well as the Na+ mechanism of the slow wave genesis.     

The role of histamine in regulation of spontaneous electrical activity of the rat ureter and bordering to bladder area

The nature of the influence of histamine on the slow wave and spike spontaneous activity of both perirenal and peribladder bordering areas of the bladder zone has been studied. It is shown that under these conditions of activated renal section of the organ, in the distal part, the decrease in frequency of the slow waves occurred. The histamine effect also contributes to improvement of the conduction of the excitation wave propagating to the bladder, which destroys the coordination of spike activity of the latter with slow waves of ureteral bordering zone.     

Analysis of electrical activities of the junction region of the ureter with bladder and surrounding zones in rats

Spontaneous electrical activity of the rat ureters per bladder zone was studied. In area of ureter connection with bladder, slow-wave activity was revealed. In bladder bordering ureter zone, rapid spike activity was found that was fully correlated with the genesis of upper located fluctuation processes.