排序方式: 共有7条查询结果,搜索用时 500 毫秒
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Corrado Viotti Falco Krüger Melanie Krebs Christoph Neubert Fabian Fink Upendo Lupanga David Scheuring Yohann Boutté Márcia Frescatada-Rosa Susanne Wolfenstetter Norbert Sauer Stefan Hillmer Markus Grebe Karin Schumacher 《The Plant cell》2013,25(9):3434-3449
Vacuoles are multifunctional organelles essential for the sessile lifestyle of plants. Despite their central functions in cell growth, storage, and detoxification, knowledge about mechanisms underlying their biogenesis and associated protein trafficking pathways remains limited. Here, we show that in meristematic cells of the Arabidopsis thaliana root, biogenesis of vacuoles as well as the trafficking of sterols and of two major tonoplast proteins, the vacuolar H+-pyrophosphatase and the vacuolar H+-adenosinetriphosphatase, occurs independently of endoplasmic reticulum (ER)–Golgi and post-Golgi trafficking. Instead, both pumps are found in provacuoles that structurally resemble autophagosomes but are not formed by the core autophagy machinery. Taken together, our results suggest that vacuole biogenesis and trafficking of tonoplast proteins and lipids can occur directly from the ER independent of Golgi function. 相似文献
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Inge Kroidl Elmar Saathoff Lucas Maganga Petra Clowes Leonard Maboko Achim Hoerauf Williams H. Makunde Antelmo Haule Prisca Mviombo Bettina Pitter Neema Mgeni Joseph Mabuye Dickens Kowuor Upendo Mwingira Mwelecele N. Malecela Thomas L?scher Michael Hoelscher 《PLoS neglected tropical diseases》2016,10(8)
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Inge Kroidl Elmar Saathof Lucas Maganga Petra Clowes Leonard Maboko Achim Hoerauf Williams H. Makunde Antelmo Haule Prisca Mviombo Bettina Pitter Neema Mgeni Joseph Mabuye Dickens Kowuor Upendo Mwingira Mwelecele N. Malecela Thomas L?scher Michael Hoelscher 《PLoS neglected tropical diseases》2016,10(4)
BackgroundAnnual mass treatment with ivermectin and albendazole is used to treat lymphatic filariasis in many African countries, including Tanzania. In areas where both diseases occur, it is unclear whether HIV co-infection reduces treatment success.MethodologyIn a general population study in Southwest Tanzania, individuals were tested for HIV and circulating filarial antigen, an indicator of Wuchereria bancrofti adult worm burden, before the first and after 2 consecutive rounds of anti-filarial mass drug administration.Conclusion/SignificanceIn an area with a high prevalence for both diseases, no difference was found between HIV-infected and uninfected individuals regarding the initial prevalence of lymphatic filariasis. A moderate but significant reduction in lymphatic filariasis prevalence and worm burden was demonstrated after two rounds of treatment with albendazole and ivermectin. Treatment effects were more pronounced in the HIV co-infected subgroup, indicating that the effectiveness of antifilarial treatment was not reduced by concomitant HIV-infection. Studies with longer follow-up time could validate the observed differences in treatment effectiveness. 相似文献
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Angelia M. Sanders Ruth Dixon Logan Stuck Michaela Kelly Geordie Woods Edridah M. Muheki Gilbert Baayenda Michael Masika Holystone Kafanikhale Upendo Mwingira Leah Wohlgemuth 《PLoS neglected tropical diseases》2021,15(11)
The World Health Organization promotes the SAFE (Surgery, Antibiotics, Facial cleanliness, and Environmental improvements) strategy for trachoma control and prevention. The F&E components of the strategy focus on promotion of healthy hygiene and sanitation behaviors. In order to monitor F&E activities implemented across villages and schools in Malawi, Tanzania, and Uganda, an F&E Monitoring and Evaluation (FEME) framework was developed to track quarterly program outputs and to provide the basis for a pre and post evaluation of the activities. Results showed an increase in knowledge at the school and household levels, and in some cases, an increase in presence of hand/face washing stations. However, this did not always result in a change in trachoma prevention behaviors such as facial cleanliness or keeping compounds free of human feces. The results highlight that the F&E programs were effective in increasing awareness of trachoma prevention but not able to translate that knowledge into changes in behavior during the time between pre and post-surveys. This study also indicates the potential to improve the data collection and survey design and notes that the period of intervention was not long enough to measure significant changes. 相似文献
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Olivier J. Wouters Philip W. Downs Kathryn L. Zoerhoff Kathryn R. Crowley Hannah Frawley Jennifer Einberg Brian K. Chu Molly A. Brady Roland Oscar Mireille Jeudi Anne-Marie Desormeaux Karleen Coly Abdel N. Direny Garib D. Thakur Raj K. Pokharel Shekhar Sharma Dharmpal P. Raman Santigie Sesay Mustapha Sonnie Bernard Kilembe Upendo Mwingira Aya Yajima 《PLoS neglected tropical diseases》2014,8(2)
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Upendo L. Msalilwa Linus K. Munishi Edna E. Makule Patrick A. Ndakidemi 《African Journal of Ecology》2020,58(3):455-467
The impact of unsustainable land-use conversions, changes in climate and anthropogenic activities on abundance and distribution of baobab populations was assessed in semi-arid regions of Tanzania. Baobabs were sampled in plots of 1 km long and a 50 m wide, which were carried out in 337 grids located in different land-use types. Transects for each land-use type were located using a stratified random sampling technique to compare baobab population variations and occurrences in semi-arid areas of Tanzania. Baobab density was found to be highest in strictly protected areas and the lowest density in unprotected areas, suggesting that anthropogenic activities coupled with local management practices within land-uses may be influencing its viability in semi-arid areas. In species like this, with less and slow recruitment rate, it takes a long time to bring the population to recovery when substantial disturbance and overutilisation have reduced the populations to certain levels. Thus, increased human and climate change pressures on land are likely to drive the species to extinction in these fragmented populations. 相似文献
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