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EXPRESSION OF cfos IN THE MEDULLA OBLONGATA AFTER CAROTID BARORECEPTOR
ACTIVATION BYELEVATED INTRASINUS PRESSURE AND ADENOSINE 总被引:2,自引:1,他引:1
在14只隔离灌流颈动脉窦区的大鼠,观察了窦内压(ISP)升高和灌流腺苷(adenosine,Ado)激活压力感受器时延髓内cfos蛋白的表达。结果显示:在孤束核、最后区、延髓腹外侧头端区和中缝苍白核可见Fos蛋白样免疫阳性反应(FLI)神经元分布,且其数量随ISP升高而增多。在给定ISP下,颈动脉窦内灌流Ado,可使上述区域中FLI表达明显增多。根据以上结果,得出如下结论:cfos在压力感受器反射延髓通路中的表达,可由ISP增高和灌流Ado而增强,表明Ado对压力感受器反射有易化作用。 相似文献
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Methane monooxygenase (MMO) enzymes catalyze the oxidation of methane to methanol in methanotrophic bacteria. Several strains of methanotrophs, including Methylococcus capsulatus (Bath), express a membrane-bound or particulate MMO (pMMO) at high copper-to-biomass ratios and a soluble MMO (sMMO) form when copper is limited. The mechanism of this "copper switch" is not understood. The mmoS gene, located downstream of the sMMO operon, encodes a sensor protein that is part of a two-component signaling system and has been proposed to play a role in the copper switch. MmoS from M. capsulatus (Bath) has been cloned, expressed, and purified. The purified protein is a tetramer of molecular mass 480 kDa. Optical spectra indicate that MmoS contains a flavin cofactor, identified as flavin adenine dinucleotide (FAD) by fluorescence spectroscopy and chromatographic analysis. The redox potential of the MmoS-bound FAD, which binds within the N-terminal PAS-PAC domains, is -290 +/- 2 mV at pH 8.0 and 25 degrees C. Despite extensive efforts, MmoS could not be loaded with Cu(I) or Cu(II), indicating that MmoS does not sense copper directly. These data suggest that MmoS functions as a redox sensor and provide new insight into the copper-mediated regulation of sMMO expression. 相似文献
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Elizabeth A. DAmbrosio Walter R. Drake Siavash Mashayekh Ophelia I. Ukaegbu Ashley R. Brown Catherine L. Grimes 《Bioorganic & medicinal chemistry letters》2019,29(10):1153-1161
The innate immune system is the body’s first defense against invading microorganisms, relying on the recognition of bacterial-derived small molecules by host protein receptors. This recognition event and downstream immune response rely heavily on the specific chemical features of both the innate immune receptors and their bacterial derived ligands. This review presents a chemist’s perspective on some of the most crucial and complex components of two receptors (NOD1 and NOD2): starting from the structural and chemical characteristics of bacterial-derived small molecules, to the specific proposed models of molecular recognition of these molecules by immune receptors, to the subsequent post-translational modifications that ultimately dictate downstream immune signaling. Recent advances in the field are discussed, as well as the potential for the development of targeted therapeutics. 相似文献
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Bezares Francisco J. Caldwell Joshua D. Glembocki Orest Rendell Ronald W. Feygelson Mariya Ukaegbu Maraizu Kasica Richard Shirey Loretta Bassim Nabil D. Hosten Charles 《Plasmonics (Norwell, Mass.)》2012,7(1):143-150
Periodic arrays of plasmonic nanopillars have been shown to provide large, uniform surface-enhanced Raman scattering (SERS)
enhancements. We show that these enhancements are the result of the combined impact of localized and propagating surface plasmon
modes within the plasmonic architecture. Here, arrays of periodically arranged silicon nanopillars of varying sizes and interpillar
gaps were fabricated to enable the exploration of the SERS response from two different structures; one featuring only localized
surface plasmon (LSP) modes and the other featuring LSP and propagating (PSP) modes. It is shown that the LSP modes determine
the optimal architecture, and thereby determine the optimum diameter for the structures at a given incident. However, the
increase in the SERS enhancement factor for a system in which LSP and PSP cooperatively interact was measured to be over an
order of magnitude higher and the peak in the diameter dependence was significantly broadened, thus, such structures not only
provide larger enhancement factors but are also more forgiving of lithographic variations. 相似文献
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