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Shastina N. S. Tuchnaya O. A. Einisman L. I. Kashiricheva I. I. Stepanov A. E. Yurkevich A. M. Shvets V. I. 《Russian Journal of Bioorganic Chemistry》2003,29(3):267-273
A partially protected phosphatidylinositol with a free hydroxyl group in the cyclitol moiety was synthesized by phosphorylation of a tetrasubstituted myo-inositol using the H-phosphonate and phosphoamidite methods. The H-phosphonate method was advantageous for the synthesis of selectively protected monophosphoinositide due to a lesser number of stages. Two schemes for the conjugation of 2',3'-didehydro-3'-de oxythymidine with phosphatidylinositol using succinic acid as a linker were tested in the synthesis of the target nucleoside phospholipid. 相似文献
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