全文获取类型
收费全文 | 1191篇 |
免费 | 137篇 |
国内免费 | 2篇 |
出版年
2022年 | 15篇 |
2021年 | 40篇 |
2020年 | 19篇 |
2019年 | 37篇 |
2018年 | 19篇 |
2017年 | 16篇 |
2016年 | 25篇 |
2015年 | 66篇 |
2014年 | 50篇 |
2013年 | 70篇 |
2012年 | 65篇 |
2011年 | 80篇 |
2010年 | 33篇 |
2009年 | 31篇 |
2008年 | 40篇 |
2007年 | 50篇 |
2006年 | 35篇 |
2005年 | 40篇 |
2004年 | 29篇 |
2003年 | 30篇 |
2002年 | 27篇 |
2001年 | 29篇 |
2000年 | 32篇 |
1999年 | 17篇 |
1997年 | 12篇 |
1996年 | 9篇 |
1995年 | 12篇 |
1994年 | 13篇 |
1993年 | 10篇 |
1992年 | 17篇 |
1991年 | 12篇 |
1990年 | 12篇 |
1989年 | 13篇 |
1987年 | 8篇 |
1986年 | 22篇 |
1985年 | 23篇 |
1984年 | 16篇 |
1983年 | 18篇 |
1982年 | 16篇 |
1981年 | 11篇 |
1979年 | 8篇 |
1978年 | 7篇 |
1977年 | 13篇 |
1976年 | 12篇 |
1975年 | 11篇 |
1974年 | 14篇 |
1973年 | 12篇 |
1971年 | 12篇 |
1968年 | 7篇 |
1966年 | 8篇 |
排序方式: 共有1330条查询结果,搜索用时 46 毫秒
1.
2.
3.
W. D. Wallis 《American anthropologist》1916,18(4):597-601
4.
Tristan J. Iseli Nigel Turner Xiao-Yi Zeng Gregory J. Cooney Edward W. Kraegen Sheng Yao Yang Ye David E. James Ji-Ming Ye 《PloS one》2013,8(4)
We recently showed that bitter melon-derived triterpenoids (BMTs) activate AMPK and increase GLUT4 translocation to the plasma membrane in vitro, and improve glucose disposal in insulin resistant models in vivo. Here we interrogated the mechanism by which these novel compounds activate AMPK, a leading anti-diabetic drug target. BMTs did not activate AMPK directly in an allosteric manner as AMP or the Abbott compound (A-769662) does, nor did they activate AMPK by inhibiting cellular respiration like many commonly used anti-diabetic medications. BMTs increased AMPK activity in both L6 myotubes and LKB1-deficient HeLa cells by 20–35%. Incubation with the CaMKKβ inhibitor, STO-609, completely attenuated this effect suggesting a key role for CaMKKβ in this activation. Incubation of L6 myotubes with the calcium chelator EGTA-AM did not alter this activation suggesting that the BMT-dependent activation was Ca2+-independent. We therefore propose that CaMKKβ is a key upstream kinase for BMT-induced activation of AMPK. 相似文献
5.
6.
7.
Linkage analysis of chromosome 17 markers in British and South African families with neurofibromatosis type 1
下载免费PDF全文
![点击此处可从《American journal of human genetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
C. G. P. Mathew K. Thorpe D. F. Easton K. S. Chin D. Jadayel M. Ponder G. Moore C. E. Wallis C. P. Slater G. De Jong P. O''''Connell R. White D. Barker B. A. J. Ponder 《American journal of human genetics》1989,44(1):38-40
Nine markers from the pericentromeric region of chromosome 17 were typed in 16 British and five South African families with neurofibromatosis type 1 (NF1). The markers--p17H8, pHHH202, and EW204--were linked to NF1 at recombination fractions less than 1%. No evidence of locus heterogeneity was detected. Inspection of recombinant events in families informative for several markers suggests that the NF1 gene is located between the markers EW301 (cen-p11.2) and EW206 (cen-q12) and possibly distal to pHHH202 (q11.2-q12). 相似文献
8.
D R Collins T J Knott R J Pease L M Powell S C Wallis S Robertson C R Pullinger R W Milne Y L Marcel S E Humphries 《Nucleic acids research》1988,16(17):8361-8375
Familial hypobetalipoproteinaemia is a rare autosomal dominant disorder in which levels of apo-B-containing plasma lipoproteins are approximately half-normal in heterozygotes and virtually absent in homozygotes. Here we describe mutations of the apo-B gene that cause two different truncated variants of apo-B in unrelated individuals with hypobetalipoproteinaemia. One variant, apo-B(His1795----Met-Trp-Leu-Val-Thr-Term) is predicted to be 1799 amino acids long and arises from deletion of a single nucleotide (G) from leucine codon 1794. This protein was found at low levels in very low density and low density lipoprotein fractions in the blood. The second, shorter variant, apo-B(Arg1306----Term), is caused by mutation of a CpG dinucleotide in arginine codon 1306 converting it to a stop codon and predicting a protein of 1305 residues. The product of this allele could not be detected in the circulation. The differences in size and behaviour of these two variants compared to apo-B100 or apo-B48 point to domains that may be important for the assembly, secretion or stability of apo-B-containing lipoproteins. 相似文献
9.
Metronidazole, tinidazole and dimetridazole were administered in the drinking water for 5 days to mice experimentally infected with Tritrichomonas muris and Tetratrichomonas microta. Mice were successfully infected with T. muris and T. microta recovered from infected gerbils. The trichomonas infection was successfully eliminated in mice given a 1% sucrose solution containing 2.5 mg/ml metronidazole or tinidazole. Mice receiving 1.0 mg/ml metronidazole, 1.0 mg/ml tinidazole and 1.2, 5.0 and 10.0 mg/ml dimetridazole failed to eliminate the trichomonas organism. A reduction in water intake was only noted with mice receiving 10 mg/ml dimetridazole. In mice receiving only 1% sucrose the infection was not eliminated. 相似文献
10.