排序方式： 共有2条查询结果，搜索用时 239 毫秒
1
1.
Howley Eimear Bestwick Michael Fradley Rosa Harrison Helen Leveridge Mathew Okada Kengo Fieldhouse Charlotte Farnaby Will Canning Hannah Sykes Andy P. Merchant Kevin Hazel Katherine Kerr Catrina Kinsella Natasha Walsh Louise Livermore David G. Hoffman Isaac Ellery Jonathan Mitchell Phillip Patel Toshal Carlton Mark Barnes Matt Miller David J. 《Neurochemical research》2017,42(11):3279-3288
Neurochemical Research - Irregular N-methyl-d-aspartate receptor (NMDAR) function is one of the main hypotheses employed to facilitate understanding of the underlying disease state of... 相似文献
2.
Graczyk PP Khan A Bhatia GS Palmer V Medland D Numata H Oinuma H Catchick J Dunne A Ellis M Smales C Whitfield J Neame SJ Shah B Wilton D Morgan L Patel T Chung R Desmond H Staddon JM Sato N Inoue A 《Bioorganic & medicinal chemistry letters》2005,15(21):4666-4670
Imidazole-based structures of p38 inhibitors served as a starting point for the design of JNK3 inhibitors. Construction of a 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold led to the synthesis of the (S)-enantiomers, which exhibited p38/JNK3 IC50 ratio of up to 10 and were up to 20 times more potent inhibitors of JNK3 than the relevant (R)-enantiomers. The JNK3 inhibitory potency correlated well with inhibition of c-Jun phosphorylation and neuroprotective properties of the compounds in low K+-induced cell death of rat cerebellar granule neurones. 相似文献
1