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The anti-inflammatory compound d-ibuprofen has been investigated for anti-inflammatory and cyclooxygenase inhibitory activity in ocular inflammation induced by paracentesis of eyes of living rabbits. d-Ibuprofen is the dextro-rotary isomer of ibuprofen, a potent non-steroidal anti-inflammatory agent. Eyes pretreated topically with d-ibuprofen 0.8% showed a significant inhibition of aqueous protein (73.0%) and prostaglandin E2 (96.4%) increase after paracentesis as compared to paracentesized untreated fellow eyes and control eyes. In aqueous humor no significant correlation between the increase in prostaglandin E2 and protein could be established after paracentesis. These results indicate that d-ibuprofen could be a useful ocular anti-inflammatory agent as cyclooxygenase inhibitor. 相似文献
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Journal of Genetics - Siamese cats have, instead of normal chromogen a weakened chromogen factor, which in cooperation with pigment factors causes the coat and eye colours characteristic for the... 相似文献
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Goedewaagen S. L. Schouten Kohlbrugge A. v. Westrienen van der Lek Tjebbes 《Genetica》1919,1(1):98-112
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