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Zamorina S. A. Shardina K. Yu. Timganova V. P. Bochkova M. S. Uzhviyuk S. V. Raev M. B. Chereshnev V. A. 《Doklady. Biochemistry and biophysics》2021,501(1):434-437
Doklady Biochemistry and Biophysics - The effect of recombinant alpha-fetoprotein (AFP) on human myeloid suppressor cell (MDSC) differentiation was studied in vitro in the presence of cytokines... 相似文献
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S. A. Zamorina V. P. Timganova M. S. Bochkova P. V. Khramtsov M. B. Raev 《Doklady biological sciences》2016,469(1):206-208
The role of heterogenic human pregnancy-specific glycoprotein (PSG), obtained by the authors’ technology, in the regulation of the indoleamine-2,3-dioxygenase (IDO) activity in female blood monocytes has been studied in vitro. PSG stimulated IDO activity under the conditions of induction of the monocytes by interferon-γ. Upon the induction of cell proliferation by lipopolysaccharides, the stimulating effect was obtained only with 10 μg/mL of PSG. Enhanced IDO activity is probably a factor of peripheral immunological tolerance and antimicrobial protection against intracellular infections in the gestation period. 相似文献
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In this work, we evaluated blocking properties of various reagents used in dot immunoassay test systems on nitrocellulose membranes employing carbon-based diagnosticum to determine antibodies to tetanus anatoxin, thermostable toxin of Yersinia pseudotuberculosis, and HIV-I. The results support the usage of a nonionic detergent Tween 20 which efficiently inhibited nonspecific protein binding to the solid-phase reagent surface and did not decrease sensitivity of the analysis. 相似文献
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M. B. Rayev L. S. Litvinova K. A. Yurova N. A. Dunets O. G. Khaziakhmatova V. P. Timganova M. S. Bochkova P. V. Khramtsov S. A. Zamorina 《Doklady biological sciences》2017,475(1):180-182
The effect of human pregnancy-specific glycoprotein (PSG) on the cytokine and chemokine production in vitro by intact mononuclear cells was studied by the method of flow fluorimetry. PSG inhibited production of the proinflammatory cytokines IL-6, IL-8, IL-17, IFN-γ, and TNF-α and chemokines CCL3/MIP-1α, CCL4/MIP-1β, CCL2/MCP-1; at the same time, PSG stimulated IL-12(p70) production. Simultaneously with increasing the VEGF level, PSG inhibited production of IL-9, IL-13, G-CSF, and GM-CSF. The PSG effect discovered can be interpreted as a contribution into the immune tolerance formation during pregnancy. 相似文献
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S. A. Zamorina V. P. Timganova M. S. Bochkova P. V. Khramtsov K. A. Fomicheva M. B. Rayev V. A. Chereshnev 《Doklady biological sciences》2018,482(1):210-213
The effect of native α-fetoprotein (AFP) on the conversion of naïve T-helpers into central memory T-cells (TCM) and effector subpopulations of the preterminally differentiated (TEM) and terminally differentiated (TEMRA) memory T-cells was studied. AFP was found to prevent the conversion of naïve T-helpers into effector subpopulations of memory T cells (TEM and TEMRA) while reducing the total production of IL-4 and IFN-γ by the studied cell populations. The data reveal a new role of AFP in the immune tolerance formation during pregnancy. 相似文献
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Zamorina S. A. Khramtsov P. V. Rayev M. B. Timganova V. P. Bochkova M. S. Nechaev A. I. Shunkin E. O. Khaziakhmatova O. G. Malaschenko V. V. Litvinova L. S. 《Doklady. Biochemistry and biophysics》2021,501(1):438-443
Doklady Biochemistry and Biophysics - In recent years, materials based on graphene oxide (GO) have been actively studied for their use in biomedicine. The aim of our study was to investigate the... 相似文献
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