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Balagopal P Pandey M Chandramohan K Somanathan T Kumar A 《World journal of surgical oncology》2003,1(1):4
Background
Choriocarcinoma is an aggressive neoplasm arising in the body of the uterus. The disease normally spreads to lung and brain. 相似文献4.
BACKGROUND: Primary central mucoepidermoid carcinoma of jaws is a rare lesion comprising 2-3% of all mucoepidermoid carcinomas reported in literature. CASE PRESENTATION: The case presented here illustrates the hypothesis that its specific pathogenesis is unknown. CONCLUSIONS: Mucoepidermoid carcinoma of the jaw is a rare tumour of unknown aetiology. Although about a 100 cases has been reported in literature, the speculation on its aetiopathogenesis has mainly centred on the pluripotential capabilities of the epithelial lining of odontogenic cysts. 相似文献
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Performance analysis of MPI collective operations 总被引:1,自引:0,他引:1
Jelena Pješivac-Grbović Thara Angskun George Bosilca Graham E. Fagg Edgar Gabriel Jack J. Dongarra 《Cluster computing》2007,10(2):127-143
Previous studies of application usage show that the performance of collective communications are critical for high-performance
computing. Despite active research in the field, both general and feasible solution to the optimization of collective communication
problem is still missing.
In this paper, we analyze and attempt to improve intra-cluster collective communication in the context of the widely deployed
MPI programming paradigm by extending accepted models of point-to-point communication, such as Hockney, LogP/LogGP, and PLogP,
to collective operations. We compare the predictions from models against the experimentally gathered data and using these
results, construct optimal decision function for broadcast collective. We quantitatively compare the quality of the model-based
decision functions to the experimentally-optimal one. Additionally, in this work, we also introduce a new form of an optimized
tree-based broadcast algorithm, splitted-binary.
Our results show that all of the models can provide useful insights into various aspects of the different algorithms as well
as their relative performance. Still, based on our findings, we believe that the complete reliance on models would not yield
optimal results. In addition, our experimental results have identified the gap parameter as being the most critical for accurate
modeling of both the classical point-to-point-based pipeline and our extensions to fan-out topologies.
相似文献
Jack J. DongarraEmail: |
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Excess mortality in persons with severe mental disorders: a multilevel intervention framework and priorities for clinical practice,policy and research agendas
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Nancy H. Liu Gail L. Daumit Tarun Dua Ralph Aquila Fiona Charlson Pim Cuijpers Benjamin Druss Kenn Dudek Melvyn Freeman Chiyo Fujii Wolfgang Gaebel Ulrich Hegerl Itzhak Levav Thomas Munk Laursen Hong Ma Mario Maj Maria Elena Medina‐Mora Merete Nordentoft Dorairaj Prabhakaran Karen Pratt Martin Prince Thara Rangaswamy David Shiers Ezra Susser Graham Thornicroft Kristian Wahlbeck Abe Fekadu Wassie Harvey Whiteford Shekhar Saxena 《World psychiatry》2017,16(1):30-40
Excess mortality in persons with severe mental disorders (SMD) is a major public health challenge that warrants action. The number and scope of truly tested interventions in this area remain limited, and strategies for implementation and scaling up of programmes with a strong evidence base are scarce. Furthermore, the majority of available interventions focus on a single or an otherwise limited number of risk factors. Here we present a multilevel model highlighting risk factors for excess mortality in persons with SMD at the individual, health system and socio‐environmental levels. Informed by that model, we describe a comprehensive framework that may be useful for designing, implementing and evaluating interventions and programmes to reduce excess mortality in persons with SMD. This framework includes individual‐focused, health system‐focused, and community level and policy‐focused interventions. Incorporating lessons learned from the multilevel model of risk and the comprehensive intervention framework, we identify priorities for clinical practice, policy and research agendas. 相似文献
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Pto mutants differentially activate Prf-dependent,avrPto-independent resistance and gene-for-gene resistance
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Pto confers disease resistance to Pseudomonas syringae pv tomato carrying the cognate avrPto gene. Overexpression of Pto under the cauliflower mosaic virus 35S promoter activates spontaneous lesions and confers disease resistance in tomato (Lycopersicon esculentum) plants in the absence of avrPto. Here, we show that these AvrPto-independent defenses require a functional Prf gene. Several Pto-interacting (Pti) proteins are thought to play a role in Pto-mediated defense pathways. To test if interactions with Pti proteins are required for the AvrPto-independent defense responses by Pto overexpression, we isolated several Pto mutants that were unable to interact with one or more Pti proteins, but retained normal interaction with AvrPto. Overexpression of two mutants, Pto(G50S) and Pto(R150S), failed to activate AvrPto-independent defense responses or confer enhanced resistance to the virulent P. s. pv tomato. When introduced into plants carrying 35S::Pto, 35S::Pto(G50S) dominantly suppressed the AvrPto-independent resistance caused by former transgene. 35S::Pto(G50S) also blocked the induction of a number of defense genes by the wild-type 35S::Pto. However, 35S::Pto(G50S) and 35S::Pto(R150S) plants were completely resistant to P. s. pv tomato (avrPto), indicating a normal gene-for-gene resistance. Furthermore, 35S::Pto(G50S) plants exhibited normal induction of defense genes in recognition of avrPto. Thus, the AvrPto-independent defense activation and gene-for-gene resistance mediated by Pto are functionally separable. 相似文献