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排序方式: 共有82条查询结果,搜索用时 15 毫秒
1.
The surface activity and enzymic properties of the factor F1, the catalytic moiety of Streptococcus faecalis H+-ATPase, has been studied at the air-water and phospholipid-water interfaces. F1 does not interact with the monolayer phospholipids, hence its adsorption on a biological membrane must be due mainly to its recognition of proteins of the hydrophobic complex. The dimensions of the F1 molecule at the air-water interface have been estimated. In the presence of Mg2+, base area is , height . Bearing in mind the size of a globular subunit, it follows from the measurements that the major F1 subunits should all lie in the same plane. The ATPase activity of F1 at the interface is inversely proportional to the monolayer density. With low density monolayer, the specific ATPase activity is higher at the interface than in the bulk of the solution.Adsorption of F1 at the interface shifts the isoelectric point of the protein, apparently due to changes in its conformation. The findings are discussed relative to the proton-active transport mechanism. 相似文献
2.
Y. Terekhov 《CMAJ》1976,115(7):631-633
Stabilomety, a method of measuring stability of stance or postural equilibrium in man, consists of transforming the mechanical oscillations of man''s "physiologic gravicentre" into electric signals, then amplifying, recording and analysing the signals. The frequency, duration and mean and maximum amplitudes of oscillations, and coefficients reflecting the influence of vision, differ in patients with various neurologic diseases and from values in healthy subjects. The method is highly sensitive and accurate, simple and rapid to use, lacks danger and discomfort and permits screening of a large number of people in a short time. 相似文献
3.
V A Lopatin M L Finkel' V V Barannikov O V Terekhov 《Biulleten' eksperimental'no? biologii i meditsiny》1978,85(1):95-96
Standard esophageal ballon with silver electrodes implanted in it is suggested for simultaneous registration of the hysteresis loop and electromyogram of the diaphragm. The method provides qualitatively new information on the work of the respiratory muscles. 相似文献
4.
Spitkovsky DM Kuzmina IV Makarenkov AS Terekhov SM Karpukhin AV 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2002,42(6):604-607
The most important stage in the making of mutations is a reparation of different DNA damage, including the more deleterious double-strand DNA breaks (DSB). The first stage of adaptive response--fundamental antimutagenic cell reaction, purposeful to reparation for induced DSB repair--is investigated in present work. Non-radioactive in situ hybridization of biotin-labeled DNA probe was used to mark chromosome 1 pericentromeric regions (PR) in G0 human lymphocytes. It was shown that under 3-10 cGy (X-radiation, 160 kV) PR become displaced from a nucleus periphery to inner territory of a nucleus. The moving process realizes during several hours after an irradiation. As far as some non-specific gene repressors are co-localized with chromosome centromeric regions it is possible hypothesizes that the displacement cause changing expression of some genes. It is possible to propose that an absence of radiation induced chromosome locus displacement may be one of causes DSB repair disturbance. This hypothesis was tested by the model. It is assumed that one consequence of the underlying defect may be inappropriate involvement of cell's recombination machinery in the repair of DSB. We studied lymphocytes of patients with hereditary BRCA2 mutation. It is thought that this gene takes part in DSB repair. The significant differences of the PR moving between control samples and the cases were revealed under 10 cGy. Similar results were observed on lymphocytes of patients with Fanconi syndrome. Thus, abnormal moving of interphase nucleus chromosomes conditioned by low-dose irradiation may suggest on imperfect machinery of DSB repair, i.e. genetic risk. We realize that further investigations are needed for definitive conclusion. 相似文献
5.
Neverova ME Adamskaia EI Terekhov SM Ivanov DS Prasolov VS Kalinin VN 《Molekuliarnaia genetika, mikrobiologiia i virusologiia》2003,(3):38-41
The physiological activity of the "recombinant" bradykinin expressed by retrovirus recombinant pPS-3-neo (brd) was tested on cultural atrial (aCMC) and ventricular (vCMC) cardiomyocytes in newborn rats. The "recombinant" bradykinin was shown to have a chronotropic effect on aCMC and an inotropic effect on vCMC. The effects are in line with the action of the synthetic bradykinin preparation at a concentration of around 10(-15) M. A pretreatment of CMC by parmidine, i.e. a bradykinin antagonist, blocked the effect of bradykinin. The contractive CMC activity in the cultural cell medium, transferred by pPS-3-neo without the bradykinin gene, was not different from the control value. 相似文献
6.
A. A. Ionin D. V. Sinitsyn Yu. V. Terekhov I. V. Kochetov A. P. Napartovich S. A. Starostin 《Plasma Physics Reports》2005,31(9):786-794
A one-dimensional model of an RF discharge in CO-containing gas mixtures is developed. The model takes into account the effect of the degree of vibrational excitation of CO molecules on the structure of the discharge and on its parameters. Experimental data are presented from measurements of the voltage-power characteristics of RF discharges in gas mixtures with different CO contents in the pressure range of 10–100 torr. The model developed is used to calculate the dependence of the root-mean-square discharge voltage on the specific power deposition in an RF discharge under our experimental conditions. The experimental data are compared to the results of numerical simulations. For working gas pressures of about 100 torr, which are typical of the operation of slab CO lasers, the calculated voltage-power characteristics of an RF discharge agree satisfactorily with those obtained experimentally. The theoretical model predicts that the vibrational excitation of CO molecules leads to a redistribution of the RF field in the discharge gap and to an increase in the laser efficiency. 相似文献
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10.
N Iu Abrikosova N N Kostiukova V P Raginskia A A Terekhov 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1985,(10):19-21
As the result of the study of blood and liquor samples from 120 newborns, Serratia marcescens was isolated in 21 cases (17.5 %). 8 strains were isolated from the environment of these patients. Almost all strains isolated from both the patients and the environment (with the exception of one environmental strain) belonged to serotype 04. The isolated S. marcescens strains were resistant to penicillin, ampicillin, streptomycin, kanamycin, oxacillin, methicillin, ceporin and moderately sensitive to polymixin. 2 strains from the environment and 9 strains from the patients were mildly sensitive to gentamicin. In one hospital all isolated strains were found to have 2 transmissive R plasmids with the molecular weight 40 and 60 megadaltons. The presence of R plasmids with the same molecular weight in all S. marcescens strains isolated in this hospital, as well as their serological identity, suggest that in all patients infection originated from a common source. 相似文献