排序方式: 共有15条查询结果,搜索用时 359 毫秒
1.
Wilbert T. Kadye Albert Chakona Lightone T. Marufu Tendai Samukange 《Hydrobiologia》2013,720(1):75-88
Non-native trout species have been associated with many negative effects in receiving ecosystems. The first aim of this study was to determine the impact of non-native rainbow trout Oncorhynchus mykiss on distribution and abundance of native mountain catfish Amphilius uranoscopus within Afro-montane streams in Nyanga Mountains, eastern Zimbabwe. The second aim was to compare macro-invertebrate community responses to the presence of the trout and the catfish. We examined trout impact on catfish’s habitat associations, whereas macro-invertebrate composition was compared using open fish and fish exclosure experiments in habitats with and without trout. Trout influenced both the distribution and abundance of the catfish that occupied shallow reaches possibly to avoid predation from trout that occurred in the deeper habitats. Within trout invaded reaches, most macro-invertebrate taxa were more abundant in exclosure than open treatments. By contrast, within trout-free reaches, most macro-invertebrates either did not differ between treatments or were generally more abundant in open than exclosure treatments. This suggests that the macro-invertebrate communities responded differently within invaded and non-invaded reaches. By influencing distribution and abundance of native biota, non-native rainbow trout may have wider ecological effects, such as influencing trophic interrelationships within invaded habitats. 相似文献
2.
Ciaranello AL Perez F Maruva M Chu J Engelsmann B Keatinge J Walensky RP Mushavi A Mugwagwa R Dabis F Freedberg KA;CEPAC-International Investigators 《PloS one》2011,6(6):e20224
Background
The Zimbabwean national prevention of mother-to-child HIV transmission (PMTCT) program provided primarily single-dose nevirapine (sdNVP) from 2002–2009 and is currently replacing sdNVP with more effective antiretroviral (ARV) regimens.Methods
Published HIV and PMTCT models, with local trial and programmatic data, were used to simulate a cohort of HIV-infected, pregnant/breastfeeding women in Zimbabwe (mean age 24.0 years, mean CD4 451 cells/µL). We compared five PMTCT regimens at a fixed level of PMTCT medication uptake: 1) no antenatal ARVs (comparator); 2) sdNVP; 3) WHO 2010 guidelines using “Option A” (zidovudine during pregnancy/infant NVP during breastfeeding for women without advanced HIV disease; lifelong 3-drug antiretroviral therapy (ART) for women with advanced disease); 4) WHO “Option B” (ART during pregnancy/breastfeeding without advanced disease; lifelong ART with advanced disease); and 5) “Option B+:” lifelong ART for all pregnant/breastfeeding, HIV-infected women. Pediatric (4–6 week and 18-month infection risk, 2-year survival) and maternal (2- and 5-year survival, life expectancy from delivery) outcomes were projected.Results
Eighteen-month pediatric infection risks ranged from 25.8% (no antenatal ARVs) to 10.9% (Options B/B+). Although maternal short-term outcomes (2- and 5-year survival) varied only slightly by regimen, maternal life expectancy was reduced after receipt of sdNVP (13.8 years) or Option B (13.9 years) compared to no antenatal ARVs (14.0 years), Option A (14.0 years), or Option B+ (14.5 years).Conclusions
Replacement of sdNVP with currently recommended regimens for PMTCT (WHO Options A, B, or B+) is necessary to reduce infant HIV infection risk in Zimbabwe. The planned transition to Option A may also improve both pediatric and maternal outcomes. 相似文献3.
The soil and plant determinants of community structures of the dominant actinobacteria in Marion Island terrestrial habitats, Sub-Antarctica 总被引:2,自引:0,他引:2
Marion Island is a Sub-Antarctic island made up of distinct ecological habitats based on soil physiochemical, plant cover and physical characteristics. The microbial diversity and ecological determinants in this harsh Sub-Antarctic environment are largely uncharacterized. Actinobacteria have diverse ecological functions related to soil and plant functioning. This study was aimed at characterizing the diversity and community structures of the dominant actinobacteria in the distinct habitats and to identify their determinant soil and plant characteristics. Using the 16S rRNA gene, the denaturing gradient gel electrophoresis patterns and clone library diversity were correlated with the soil and plant characteristics. Multivariate statistical methods were also used to identify determinant soil and plant characteristics. Salinity and pH were the most important soil determinants, and a number of important site-specific plant species may have been important. The Coastal Fellfield Habitat was dominated by sequences of the suborders Micrococcineae (44%) and Propionibacterineae (18%), with salinity identified as the principal determinant. The Cotula Herbfield Habitat was dominated by Frankineae (37%) and Streptosporangineae (38%), which were correlated with organic nutrient concentrations. The Wet Mire Habitat was dominated by Acidimicrobineae (61%), with moisture and organic carbon content as principal components. Culture-dependent studies were complementary to culture-independent studies with the majority of actinobacteria isolated not identified in 16S rRNA gene clone libraries. This study demonstrates how the soil physiochemical characteristics and plant species independently determine the community structures of the dominant actinobacteria in distinct ecological habitats. These factors subsequently influence their ecological adaptation, roles and functions. 相似文献
4.
Julia Drylewicz Nienke Vrisekoop Tendai Mugwagwa Anne Bregje de Boer Sigrid A. Otto Mette D. Hazenberg Kiki Tesselaar Rob J. de Boer José A. M. Borghans 《PloS one》2016,11(3)
Naive T cells in untreated HIV-1 infected individuals have a reduced T-cell receptor excision circle (TREC) content. Previous mathematical models have suggested that this is due to increased naive T-cell division. It remains unclear, however, how reduced naive TREC contents can be reconciled with a gradual loss of naive T cells in HIV-1 infection. We performed longitudinal analyses in humans before and after HIV-1 seroconversion, and used a mathematical model to investigate which processes could explain the observed changes in naive T-cell numbers and TRECs during untreated HIV-1 disease progression. Both CD4+ and CD8+ naive T-cell TREC contents declined biphasically, with a rapid loss during the first year and a much slower loss during the chronic phase of infection. While naive CD8+ T-cell numbers hardly changed during follow-up, naive CD4+ T-cell counts continually declined. We show that a fine balance between increased T-cell division and loss in the peripheral naive T-cell pool can explain the observed short- and long-term changes in TRECs and naive T-cell numbers, especially if T-cell turnover during the acute phase is more increased than during the chronic phase of infection. Loss of thymic output, on the other hand, does not help to explain the biphasic loss of TRECs in HIV infection. The observed longitudinal changes in TRECs and naive T-cell numbers in HIV-infected individuals are most likely explained by a tight balance between increased T-cell division and death, suggesting that these changes are intrinsically linked in HIV infection. 相似文献
5.
6.
Dominique Joly Marie-Louise Cariou Tendai Mhlanga-Mutangadura Daniel Lachaise 《Genetica》2010,138(1):139-152
It is commonly recognized that speciation does not necessarily imply extensive variation between populations, and what the
speciation process per se consists of still remains an unanswered question. We advocate here that the variation of male terminalia
does not necessarily result in noticeable reproductive isolation. We report whether there is invariance or variance of traits
central to sexual selection processes (i.e. male terminalia and sperm length) compared to traits which are generally assumed
to vary more neutrally (i.e. allozymes) in the strictly Afrotropical forest-dwelling continental species Drosophila teissieri. Three geographic blocks can be recognized along the present range of the species. Our data suggest that the components of
the species integrity do not obey the variance/invariance alternative consistently. Male terminalia and allozymes show extensive
variation while sperm length distribution is strikingly similar between the geographic blocks. It is therefore inferred that
sperm length might be one of the major targets of stabilizing selection. Finally, it is suggested that the striking fit between
the extent of sperm heteromorphism (within male) and sperm polymorphism (between males) is instrumental in maintaining the
species integrity. 相似文献
7.
8.
Miriam Kolko Fia Vosborg Ulrik L. Henriksen Md Mahdi Hasan-Olive Elisabeth Holm Diget Rupali Vohra Iswariya Raja Sridevi Gurubaran Albert Gjedde Shelton Tendai Mariga Dorte M. Skytt Tor Paaske Utheim Jon Storm-Mathisen Linda H. Bergersen 《Neurochemical research》2016,41(6):1229-1236
In retina, like in brain, lactate equilibrates across cell membranes via monocarboxylate transporters and in the extracellular space by diffusion, forming a basis for the action of lactate as a transmitter of metabolic signals. In the present paper, we argue that the lactate receptor GPR81, also known as HCAR1, may contribute importantly to the control of retinal cell functions in health and disease. GPR81, a G-protein coupled receptor, is known to downregulate cAMP both in adipose and nervous tissue. The receptor also acts through other down-stream mechanisms to control functions, such as excitability, metabolism and inflammation. Recent publications predict effects of the lactate receptor on neurodegeneration. Neurodegenerative diseases in retina, where the retinal ganglion cells die, notably glaucoma and diabetic retinopathy, may be linked to disturbed lactate homeostasis. Pilot studies reveal high GPR81 mRNA in retina and indicate GPR81 localization in Müller cells and retinal ganglion cells. Moreover, monocarboxylate transporters are expressed in retinal cells. We envision that lactate receptors and transporters could be useful future targets of novel therapeutic strategies to protect neurons and prevent or counteract glaucoma as well as other retinal diseases. 相似文献
9.
10.
We use a mathematical model to determine the factors affecting the delayed or rare coreceptor switch in HIV-1 subtype C infected
individuals. The model takes into account the two main target cells for the CXCR4-tropic and CCR5-tropic virus and includes
the the lytic and non-lytic immune responses. Computer-based simulations and a sensitivity analysis of the model predict that
a persistent immune response suppresses the CXCR4-tropic virus to low levels and hence preventing a phenotypic switch. However,
not only should the immune response be persistent, but it should have an efficient lytic immune response rather that an efficient
non-lytic response. In addition, we also find that the availability of macrophage cells and enhanced viral kinetics are also
crucial for the dominance of the R5 strain. We suggest that an altered host environment probably as a result of immune activation
may explain the difference in coreceptor switching kinetics between HIV-1 subtype B and subtype C individuals. 相似文献