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1.
Tamanna Jahangir 《Journal of enzyme inhibition and medicinal chemistry》2013,28(6):888-894
In the present study we have evaluated the antigenotoxic effects of Farnesol (FL) a 15-carbon isoprenoid alcohol against benzo (a) pyrene [B(a)P] (125 mg kg? 1.b.wt oral) induced toxicity. B(a)P administration lead to significant induction in Cytochrome P450 (CYP) content and aryl hydrocarbon hydrolase (AHH) activity (p < 0.001), DNA strand breaks and DNA adducts (p < 0.001) formation. FL was shown to suppress the activities of both CYP and AHH (p < 0.005) in modulator groups. FL pretreatment significantly (p < 0.001) restored depleted levels of reduced glutathione (GSH), quinone reductase (QR) and glutathione –S-transferase (GST). A simultaneous significant and at both the doses reduction was seen in DNA strand breaks and in in-vivo DNA adducts formation (p < 0.005), which gives some insight on restoration of DNA integrity. The results support the protective nature of FL. Hence present data supports FL as a future drug to preclude B (a) P induced toxicity. 相似文献
2.
F. Azam 《Plant and Soil》1990,125(2):255-262
A pot experiment was conducted to study the effect of organic and inorganic nitrogen (N) sources on the yield and N uptake
of rice from applied and native soil-N. The residual effect of these N sources on a succeeding wheat crop was also studied.
Organic N was applied in the form of 15N-labelled Sesbania aculeata L., a legume, and inorganic N in the form of 15N-labelled ammonium sulphate. The two sources were applied to the soil separately or together at the time of transplanting
rice.
Recovery of N by rice from both the applied sources was quite low but both sources caused significant increases in biomass
and N yield of rice. Maximum increase was recorded in soil treated with organic N. The residual value of the two materials
as source of N for wheat was not significant; the wheat took up only a small fraction of the N initially applied. Loss of
N occurred from both applied N sources, the losses being more from inorganic N.
Both applied N sources caused a substantial increase in the availability of soil-N to rice and wheat; most of this increase
was due to organic N and was attributed to the so-called ‘priming’ effect or ANI (added nitrogen interaction) of the applied
material. 相似文献
3.
Changes in the levels of catecholamines, hexokinase and glucose 6-phosphate dehydrogenase in red cell aging 总被引:1,自引:0,他引:1
The activity of the enzymes hexokinase and glucose 6-phosphate dehydrogenase and the level of catecholamines were measured in isolated rat Red Blood Cells (RBC) during cellular aging. The results clearly showed a linear decline in the two enzyme profiles with corresponding increase in age of RBC. A decrease of 75-85% in the activities were found in the oldest cell fractions as compared to the youngest. The levels of glycosylated haemoglobin and catecholamines were found to increase with aging. A correlation can probably be established between the enzyme activities, the levels of glycosylated haemoglobulin and catecholamines during aging. 相似文献
4.
Glutathione peroxidase and glutathione reductase activities were measured in erythrocytes from control, diabetic and insulin-treated diabetic rats. A significant decrease in the activity of glutathione peroxidase and an increase in the glutathione reductase activity were found with increase in the time of diabetes which may result in the alteration in the activity of the pentose phosphate pathway by the modulation of the levels of NADPH. Insulin administration reverses the change in the activity of glutathione peroxidase but does not reverse the glutathione reductase activity during diabetes. The overall changes may be due to changes in the levels of insulin, triiodothyronine and thyroxine. 相似文献
5.
Nano- and picoplankton growth and production in the Bay of Villefranche sur Mer (N.W. Mediterranean)
R. W. Sheldon F. Rassoulzadegan F. Azam T. Berman D. S. Bezanson M. Bianchi D. Bonin Å Hagström M. Laval-Peuto J. Neveux P. Raimbault A. Rivier B. Sherr E. Sherr F. Van Wambeke J. Wikner A. M. Wood C. M. Yentsch 《Hydrobiologia》1992,241(2):91-106
Plankton production in the Bay of Villefranche was relatively constant during March and April 1986 but the particle size at which the production occurred was more variable. At the beginning of the study, production was dominated by the larger (ca. 6 m) flagellates but towards the end it was more or less equally divided between the nano- and picoplankton. There were considerable differences in the estimates of population growth rates, depending on the methods used, but on average the population doubling times were close to 12 hours for autotrophs and 24 hours for heterotrophs. As autotrophs do not grow during the night, each population was therefore doubling once per day. It seemed that each of the nanoor picoplankton populations could adversely affect the growth of the others. This could be either by simple predation or by some form of inhibition. Although nutrient levels in the bay were uniformly low, the addition of nutrients did not always stimulate algal growth. The plankton populations seemed to be both in a state of equilibrium and intense ecological competition. 相似文献
6.
The mechanism of d-glucose transport in the marine bacterium Serratia marinorubra was investigated. Uptake is mediated by a single, constitutive phosphoenolpyruvate:sugar phosphotransferase system (PTS), resulting in phosphorylation of d-glucose to d-glucose phosphate during transport. The system is saturable (K(m) = 6.4 x 10 M) and highly temperature dependent, with a Q(10) of 3.5 between 5 and 15 degrees C. The system is highly specific for d-glucose; structurally related sugars and sugar alcohols did not significantly compete with d-glucose for transport. The PTS requires Mg (K(m) = 2.5 x 10 M), but its activity is otherwise unaffected by salinity changes over the range tested (0 to 35 per thousand). S. marinorubra differs from other gram-negative organisms (Escherichia coli and Salmonella typhimurium) in that its glycerol (non-PTS substrate) permease is not regulated by the presence of glucose (PTS substrate). 相似文献
7.
Bardet–Biedl Syndrome is a multisystem autosomal recessive disorder characterized by central obesity, polydactyly, hypogonadism, learning difficulties, rod-cone dystrophy and renal dysplasia. Bardet–Biedl Syndrome has a prevalence rate ranging from 1 in 100,000 to 1 in 160,000 births although there are communities where Bardet–Biedl Syndrome is found at a higher frequency due to consanguinity. We report here a Pakistani consanguineous family with two affected sons with typical clinical features of Bardet–Biedl Syndrome, in addition to abnormal liver functioning and bilateral basal ganglia calcification, the latter feature being typical of Fahr's disease. Homozygous regions obtained from SNP array depicted three known genes BBS10, BBS14 and BBS2. Bidirectional sequencing of all coding exons by traditional sequencing of all these three genes showed a homozygous deletion of 10 nucleotides (c.1958_1967del), in BBS10 in both affected brothers. The segregation analysis revealed that the parents, paternal grandfather, maternal grandmother and an unaffected sister were heterozygous for the deletion. Such a large deletion in BBS10 has not been reported previously in any population and is likely to be contributing to the phenotype of Bardet–Biedl Syndrome in this family. 相似文献
8.
9.
We report here the synthesis, characterization and in vitro antiamoebic activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazones (TSC), 1–5, and their bidentate complexes [Ru(η4-C8H12)(TSC)Cl2] 1a–5a. The biological studies of these compounds were investigated against HK-9 strain of Entamoeba histolytica and the concentration causing 50% cell growth inhibition (IC50) was calculated in the micromolar range. The ligands exhibited antiamoebic activity in the range (2.05–5.29 μM). Screening results indicated that the potencies of the compounds increased by the incorporation of ruthenium(II) in the thiosemicarbazones. The complexes 1a–5a showed antiamoebic activity with an IC50 of 0.61–1.43 μM and were better inhibitors of growth of E. histolytica, based on IC50 values. The most promising among them is Ru(II) complex 2a having 1,2,3,4-tetrahydroquinoline as N4 substitution. 相似文献
10.
Panahi Heidar Ali Bolhassani Azam Javadi Gholamreza Noormohammadi Zahra 《International journal of peptide research and therapeutics》2020,26(4):1847-1861
International Journal of Peptide Research and Therapeutics - The accurate modelling and scoring of protein–peptide (Pr–Pe) complexes are determining factors in the drug discovery... 相似文献