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Hattan Jun-ichiro Shindo Kazutoshi Ito Tomoko Shibuya Yurica Watanabe Arisa Tagaki Chie Ohno Fumina Sasaki Tetsuya Ishii Jun Kondo Akihiko Misawa Norihiko 《Planta》2016,243(4):959-972
Planta - A novel terpene synthase ( Tps ) gene isolated from Camellia brevistyla was identified as hedycaryol synthase, which was shown to be expressed specifically in flowers. Camellia plants are... 相似文献
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Arumugam S Thandavarayan RA Arozal W Sari FR Giridharan VV Soetikno V Palaniyandi SS Harima M Suzuki K Nagata M Tagaki R Kodama M Watanabe K 《Free radical research》2012,46(2):154-163
In order to test the hypothesis that treatment with quercetin at a dose of 10 mg/kg protects from the progression of experimental autoimmune myocarditis (EAM) to dilated cardiomyopathy (DCM), we have used the rat model of EAM induced by porcine cardiac myosin. Our results identified that the post-myocarditis rats suffered from elevated endoplasmic reticulum (ER) stress and adverse cardiac remodelling in the form of myocardial fibrosis, whereas the rats treated with quercetin have been protected from these changes as evidenced by the decreased myocardial levels of ER stress and fibrosis markers when compared with the vehicle-treated DCM rats. In addition, the myocardial dimensions and cardiac function were preserved significantly in the quercetin-treated rats in comparison with the DCM rats treated with vehicle alone. Interestingly, the rats treated with quercetin showed significant suppression of the myocardial endothelin-1 and also the mitogen activated protein kinases (MAPK) suggesting that the protection offered by quercetin treatment against progression of EAM involves the modulation of MAPK signalling cascade. Collectively, the present study provides data to support the role of quercetin in protecting the hearts of the rats with post myocarditis DCM. 相似文献
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