全文获取类型
收费全文 | 580篇 |
免费 | 54篇 |
出版年
2023年 | 5篇 |
2022年 | 12篇 |
2021年 | 19篇 |
2020年 | 11篇 |
2019年 | 10篇 |
2018年 | 16篇 |
2017年 | 11篇 |
2016年 | 20篇 |
2015年 | 17篇 |
2014年 | 17篇 |
2013年 | 21篇 |
2012年 | 32篇 |
2011年 | 28篇 |
2010年 | 15篇 |
2009年 | 12篇 |
2008年 | 17篇 |
2007年 | 7篇 |
2006年 | 13篇 |
2005年 | 13篇 |
2004年 | 20篇 |
2003年 | 18篇 |
2002年 | 19篇 |
2001年 | 6篇 |
1999年 | 5篇 |
1998年 | 6篇 |
1996年 | 8篇 |
1982年 | 5篇 |
1981年 | 8篇 |
1980年 | 5篇 |
1978年 | 4篇 |
1976年 | 7篇 |
1974年 | 6篇 |
1973年 | 8篇 |
1972年 | 4篇 |
1971年 | 6篇 |
1970年 | 4篇 |
1969年 | 7篇 |
1968年 | 4篇 |
1965年 | 4篇 |
1964年 | 4篇 |
1962年 | 6篇 |
1949年 | 4篇 |
1939年 | 5篇 |
1937年 | 4篇 |
1936年 | 7篇 |
1935年 | 5篇 |
1929年 | 4篇 |
1908年 | 5篇 |
1903年 | 4篇 |
1900年 | 4篇 |
排序方式: 共有634条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
EA Dukhanina TI Lukyanova EA Romanova V Guerriero NV Gnuchev GP Georgiev DV Yashin LP Sashchenko 《Cell cycle (Georgetown, Tex.)》2015,14(22):3635-3643
PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7–Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4+ and CD8+ lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response. 相似文献
5.
6.
7.
Sydney Brenner 《Genome biology》2002,3(9):comment1013.1-comment10132
8.
Sydney M. Finegold 《The Western journal of medicine》1969,110(6):455-459
Anaerobic bacteria predominate in the normal human fecal flora, out-numbering aerobes at least 100 to one. The two most prevalent organisms are Bacteroides fragilis and Bifidobacterium. Ileostomy flora is, on the other hand, chiefly aerobic and the total count is lower (108 per ml of fluid, compared to 1010 per gram for feces). In normal people, small bowel bacterial counts are generally 105 per ml or less. The upper small bowel consists primarily of Gram-positive aerobes in small numbers. In the terminal ileum, counts are higher and aerobes and anaerobes are present in equal numbers. In the presence of acute obstruction and certain bowel stasis or other syndromes, the small bowel flora may become relatively profuse and fecal in type. The stomach normally has less than 103 organisms per ml but counts are higher in gastric samples with pH above 4.0.Intestinal bacteria are important in such processes as conversion of bilirubin to urobilinogen, supply of vitamin K to the host, defense against infection, bile acid deconjugation and conversion, infections related to the bowel, the malabsorption of blind loop and other bacterial overgrowth syndromes, and hepatic coma. 相似文献
9.
Endogenous Benzodiazepine Receptor Ligands in Human and Animal Hepatic Encephalopathy 总被引:6,自引:1,他引:5
Marjut Olasmaa Jeffrey D. Rothstein Alessandro Guidotti Richard J. Weber† Steven M. Paul‡ Sydney Spector§ Maria L. Zeneroli Mario Baraldi Erminio Costa 《Journal of neurochemistry》1990,55(6):2015-2023
The role of endogenous benzodiazepine receptor ligands in the pathogenesis of hepatic encephalopathy was studied in humans and in rat models of hepatic encephalopathy. Endogenous benzodiazepine ligands were extracted from rat brain and human CSF by acid treatment and purification by HPLC. Detection and partial characterization of these endogenous benzodiazepine ligands were carried out using both radioreceptor binding assays and radioimmunoassays with anti-benzodiazepine antibodies. Four different benzodiazepine receptor ligands were identified in human and rat tissue, two of which may be diazepam and desmethyldiazepam, based on elution profiles and anti-benzo-diazepine antibody reactivity. Human CSF and serum from patients with hepatic encephalopathy contained approximately 10 times more endogenous benzodiazepine receptor ligand than CSF from controls or nonencephalopathic patients with liver disease. The levels of brain benzodiazepine receptor ligand compounds were also increased approximately 10-fold in rats suffering from fulminant hepatic failure, but not in rats with portacaval shunts, a model of chronic hepatic disease. The increased concentrations of these substances could be behaviorally significant and may contribute to the pathogenesis of hepatic encephalopathy. 相似文献