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Semi-synthesis and bio-evaluation of polybrominated diphenyl ethers from the sponge Dysidea herbacea
Srikanth Reddy T Suryakiran N Narasimhulu M Ramesh D Chinni Mahesh K Sai Krishna A Kavitha P Venkateswara Rao J Venkateswarlu Y 《Bioorganic & medicinal chemistry letters》2012,22(14):4900-4906
The sponge Dysidea herbacea was collected from the Mandapam Coast, Tamilnadu, India. Isolated gram quantities of hydroxylated polybrominated diphenyl ether (HO-PBDE) and semi-synthesized a series of new PBDEs derivatives and tested them for antibacterial and cytotoxic activities. 相似文献
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Singanaboina Rajaram Udugu Ramulu Dasari Ramesh Dudem Srikanth Papri Bhattacharya Peddikotla Prabhakar Shasi V. Kalivendi Katragadda Suresh Babu Yenamandra Venkateswarlu Suryakiran Navath 《Bioorganic & medicinal chemistry letters》2013,23(23):6234-6238
The chemical investigation of soft coral Sinularia kavarattiensis is described. It yielded furano-sesquiterpene carboxylic acids 1 and 2 and their methyl esters 3 and 4. Semi-synthesis of furano-sesquiterpene carboxylic acid 1 gave amide derivatives 5–12. Structures of all the compounds were established by IR, NMR and mass spectral analysis. Interestingly all compounds are selectively potent on leukemia cell line. All these compounds were screened for cytotoxic activity against five human cancer cell lines (leukemia, prostate, lung, breast and cervix). Among these compounds 9 and 10 showed promising activity against leukemia and prostate cancer cell lines. 相似文献
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Chiara Montemurro Suryakiran Vadrevu Tatyana Gurlo Alexandra E Butler Kenny E Vongbunyong Anton Petcherski 《Cell cycle (Georgetown, Tex.)》2017,16(21):2086-2099
Cell replication is a fundamental attribute of growth and repair in multicellular organisms. Pancreatic beta-cells in adults rarely enter cell cycle, hindering the capacity for regeneration in diabetes. Efforts to drive beta-cells into cell cycle have so far largely focused on regulatory molecules such as cyclins and cyclin-dependent kinases (CDKs). Investigations in cancer biology have uncovered that adaptive changes in metabolism, the mitochondrial network, and cellular Ca2+ are critical for permitting cells to progress through the cell cycle. Here, we investigated these parameters in the replication-competent beta-cell line INS 832/13. Cell cycle synchronization of this line permitted evaluation of cell metabolism, mitochondrial network, and cellular Ca2+ compartmentalization at key cell cycle stages. The mitochondrial network is interconnected and filamentous at G1/S but fragments during the S and G2/M phases, presumably to permit sorting to daughter cells. Pyruvate anaplerosis peaks at G1/S, consistent with generation of biomass for daughter cells, whereas mitochondrial Ca2+ and respiration increase during S and G2/M, consistent with increased energy requirements for DNA and lipid synthesis. This synchronization approach may be of value to investigators performing live cell imaging of Ca2+ or mitochondrial dynamics commonly undertaken in INS cell lines because without synchrony widely disparate data from cell to cell would be expected depending on position within cell cycle. Our findings also offer insight into why replicating beta-cells are relatively nonfunctional secreting insulin in response to glucose. They also provide guidance on metabolic requirements of beta-cells for the transition through the cell cycle that may complement the efforts currently restricted to manipulating cell cycle to drive beta-cells through cell cycle. 相似文献
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Gary V. Martinez Suryakiran Navath Kamini Sewda Venkataramanarao Rao Parastou Foroutan Ramesh Alleti Valerie E. Moberg Ali M. Ahad Domenico Coppola Mark C. Lloyd Robert J. Gillies David L. Morse Eugene A. Mash 《Bioorganic & medicinal chemistry letters》2013,23(7):2061-2064
A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd–DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47 h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated. 相似文献
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