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O.?A.?Lapchinskaya G.?S.?Katrukha E.?G.?Gladkikh V.?V.?Kulyaeva P.?V.?Coodan A.?P.?Topolyan V.?A.?Alferova V.?V.?Pogozheva M.?A.?Sukonnikov E.?A.?Rogozhin I.?A.?Prokhorenko V.?A.?Brylev A.?M.?Korolev M.?S.?Slyundina R.?S.?Borisov M.?V.?Serebryakova M.?V.?Shuvalov A.?L.?Ksenofontov L.?G.?Stoyanova I.?A.?Osterman A.?A.?Formanovsky V.?N.?Tashlitsky L.?A.?Baratova A.?V.?Timofeeva A.?P.?TyurinEmail author 《Russian Journal of Bioorganic Chemistry》2016,42(6):664-671
A concentrate with the antimicrobial activity has been isolated from the culture broth of Streptomyces roseoflavus INA-Ac-5812. Its further fractionation by reversed-phase HPLC has resulted in six fractions. It has been established by MALDI-TOF and ESI-MSn precision mass-spectrometry methods that the main components of the complex antibiotic are several closely related compounds, presumably of a glycopeptide nature. The fraction containing an individual component with a mass of 1845.788 Da has been characterized by UV/Vis absorbance and fluorescence spectra, amino acid analysis, and derivatization with tris(2,6-dimethoxyphenyl)methyl cation. The activity of fractions against pathogenic microbes has been studied. The results allow the supposition that the INA-5812 antibiotic complex is a glyco- or lipoglycopeptide antibiotic of a new type, which is very promising for further study. 相似文献
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Analysis of Content of 2-Oxoacids in Rat Brain Extracts Using High-Performance Liquid Chromatography
Tashlitsky Vadim N. Artiukhov Artem V. Fedorova Natalia V. Sukonnikov Maxim A. Ksenofontov Alexander L. Bunik Victoria I. Baratova Ludmila A. 《Biochemistry. Biokhimii?a》2022,87(4):356-365
Biochemistry (Moscow) - 2-Oxoacids are involved in a number of important metabolic processes and can be used as biomarkers in some human diseases. A new optimized method for quantification of... 相似文献
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