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Strakhovskaya M. G. Belenikina N. S. Ivanova E. V. Chemeris Yu. K. Stranadko E. F. 《Microbiology》2002,71(3):298-301
Photodithazine, a glucosamine salt of chlorin e
6, is highly effective in sensitization of Candida guilliermondii cells to visible light. The sensitizing effect of photodithazine was found to be related to free or cell surface–bound molecules of this dye. Sodium azide (a singlet oxygen quencher) and propyl gallate (an inhibitor of lipid peroxidation) protected yeast cells from the photodithazine-enhanced photoinactivation. 相似文献
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The photodynamic therapy of tumors is a modern therapeutic modality for organ-preserving treatment of oncological diseases. The method is based on selective laser irradiation of tumor tissues previously sensitized by tumorotropic dyes. During the last decades, photodynamic therapy has become worldwide known as a proper approach to the treatment of the patients with malignant tumors of various locations and a number of nontumoral diseases. The characteristics of modern photosensitizers and light sources for photodynamic therapy and their clinical applications are reviewed. 相似文献
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Strakhovskaia MG Parkhomenko IM Rumbal' IaV Zarubina AP Danilov VS Stranadko EF 《Mikrobiologiia》2002,71(3):345-348
The photoquenching of the bioluminescence of the genetically engineered Escherichia coli TG1 (pXen7) strain was studied in the presence of the photosensitizer photodithazine, a glucosamine salt of chlorin e6. The photosensitized quenching of the bioluminescence was found to correlate with the colony-forming ability of the strain. The data obtained are discussed from the standpoint of using biosensor luminescent bacterial systems for the assessment of the efficiency of photosensitizers in antimicrobial photochemotherapy. 相似文献
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Strakhovskaia MG Belenikina NS Ivanova EV Chemeris IuK Stranadko EF 《Mikrobiologiia》2002,71(3):349-353
Photodithazine, a glucosamine salt of chlorin e6, enhanced the inactivation of Candida guilliermondii cells by visible light. The sensitizing effect of photodithazine was found to be related to free or cell surface-bound molecules of this dye. Sodium azide (a singlet oxygen quencher) and propyl gallate (an inhibitor of lipid peroxidation) protected yeast cells from the photodithazine-enhanced photoinactivation. 相似文献
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Strakhovskaya M. G. Parkhomenko I. M. Rumbal' Ya. V. Zarubina A. P. Danilov V. S. Stranadko E. F. 《Microbiology》2002,71(3):294-297
The photoquenching of the bioluminescence of the genetically engineered Escherichia coli TG1 (pXen7) strain was studied in the presence of the photosensitizer photodithazine, a glucosamine salt of chlorin e
6. The photosensitized quenching of the bioluminescence was found to correlate with the colony-forming ability of the strain. The data obtained are discussed from the standpoint of using biosensor luminescent bacterial systems for the assessment of the efficiency of photosensitizers in antimicrobial photochemotherapy. 相似文献
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Tolstykh PI Stranadko EF Koraboev UM Urinov AIa Tolstykh MP Terekhova RP Volkova NN Duvanskiĭ VA 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2001,(2):85-87
The in vitro study of the influence of photodynamic action (with the use of photosensitizer "Photosens", laser and non-laser irradiation) on the strains of the main representatives purulent wound microflora was carried out. Staphylococcus aureus, S. epidermidis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis cultures have been isolated from wound secretions and identified. The photosensitizer was shown to produce no bactericidal effect by itself. Irradiation with laser and non-laser light sources induced a sharp decrease in the number of viable cells in the cultures under study. The irradiation of the photosensitizer led to its activation, manifested in bactericidal action. The results thus obtained confirm good prospect of using photodynamic therapy for the treatment of purulent wounds. 相似文献
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