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排序方式: 共有668条查询结果,搜索用时 9 毫秒
1.
Samaiya Puneet K. Krishnamurthy Sairam Kumar Ashok 《Molecular and cellular biochemistry》2021,476(12):4421-4434
Molecular and Cellular Biochemistry - Perinatal asphyxia (PA)-induced brain injury may present as hypoxic-ischemic encephalopathy in the neonatal period, and long-term sequelae such as spastic... 相似文献
2.
The mutagenic effect of an antihypertensive drug, propranolol, was studied on somatic and germ cells of Swiss albino mice. The induction of a significant increase in the frequency of micronuclei in erythrocytes was observed at higher dose levels, whereas, in germ cells, propranolol failed to induce significant chromosomal aberrations at any dose tested. 相似文献
3.
Résumé L'AcridienGesonula punctifrons
St?l attaque la Jacinthe d'eau (Eichhornia crassipes) dans plusieurs parties de l'Inde et est adapté à un habitat aquatique ou semi-aquatique. Les œufs, pondus dans les pétioles
des feuilles, éclosent en 3 à 4 semaines. Les larves se développent en 4 à 5 semaines et demi, avec 5 mues. Les adultes vivent
au maximum 4 à 5 mois en s'alimentant seulement de Jacinthe d'eau. En essais de laboratoire cet Acridien se nourrit activement
deCanna orientalis dont les tiges sont percées de trous pour la ponte par les femelles, mais aucun œuf n'est déposé. Quarante trois autres plantes
d'intérêt économique ont été expérimentées: plusieurs d'entre elles ont été l'objet d'attaques légères à modérées. L'analyse
de la littérature concernant les plantes-h?tes du genreGesonula et la distribution deG. punctifrons montrent que cette espèce s'est adaptée secondairement àE. crassipes. Bien que cet Acridien s'observe en grand nombre dans quelques régions, l'ensemble de ses dégats à la mauvaise herbe n'est
pas suffisant pour assurer le contr?le de celle-ci.
This research has been financed in part by a grant made by the United States Department of Agriculture under P. L. 480. 相似文献
This research has been financed in part by a grant made by the United States Department of Agriculture under P. L. 480. 相似文献
4.
A leaf tip hooded mutant was isolated in the progenies of the irradiated seeds of a commercial tobacco variety, namely Delcrest. The mutant character was determined as monogenic recessive. Along with leaf tip hooding, certain other characters such as increase in size of leaves, number and clasping arrangement of leaves on stem, and delayed flowering, were found to be closely associated and this was attributed to the pleiotropic effect of the leaf tip hooding gene. 相似文献
5.
A 2-month-old female with intrauterine and postnatal growth retardation, multiple congenital anomalies, absent right kidney, congenital heart disease was investigated. Her karyotype revealed, 46,XX,-10,+der(10), t(10;18) (p15;q12) pat. The child died at 2 months 2 weeks. This is the third case of trisomy 18q resulting from translocation of chromosome 10 and 18. 相似文献
6.
Segregation of Cytoplasmic Incompatibility Properties in CULEX PIPIENS FATIGANS 总被引:2,自引:2,他引:0
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Sarala K. Subbarao B. S. Krishnamurthy C. F. Curtis T. Adak R. K. Chandrahas 《Genetics》1977,87(2):381-390
Maternally inherited variants, which arose within a laboratory colony of Culex pipiens fatigans, have been studied by rearing cultures from single egg rafts. Segregation, i.e, variation of cytoplasmic incompatibility properties between the male progeny of individual females, was demonstrated. Also, from the daughters of individual females, sub-lines were derived within which all the males showed the same incompatibility or compatibility properties. Among the descendants of tetracycline-treated individuals were lines which superficially simulated these phenomena, but theses lines ultimately reverted to the cytoplasmic compatibility type of the strain which was submitted to the treatment. The types of variation s in cytoplasmic incompatibility properties that have been studied are discussed. 相似文献
7.
The results presented in this paper show that lysis of human erythrocytes by linoleic acid is not caused by peroxidation of
the fatty acid. Peroxidase, superoxide dismutase and scavengers of O
2
−
and OH had no effect on the lysis while catalase showed only marginal inhibition suggesting that O
2
−
, OH, O
2
−
and H2O2 do not play any direct role in hemolysis by linoleic acid. Generators of H2O2 inhibited the lysis completely and methemoglobin cells were more resistant to hemolysis by linoleic acid. The fatty acid
did neither bind to nor fomed complex with red cell ghosts. Membrane oxidation of sulphydryl groups was also not involved
in the lysis. Β-Carotene, retinol and bile salts enhanced the lysis, while, cholesterol but not cholesterol acetate, inhibited
it. Taurocholate-pretreated cells were more susceptible to linoleic acid lysis. These observations suggested-that lysis by
linoleic acid may be due to its detergent property. 相似文献
8.
9.
Dhurgham Al-Fahad Firas Alyaseen Ahmed Al-Amery Gagandeep Singh Mote Srinath Hafiz Muzzammel Rehman Yahya Abbas 《Reports of Biochemistry & Molecular Biology》2022,11(2):262
Background:The assembly and disassembly of the focal adhesions (FA) components occurs throughout life cycle of adhesion, with conservation of balance between removal and recruitment rate during temporal stages. Previous studies have demonstrated that phosphotidyilinositols play a role in regulating FA turnover. However, a little attention has been given to quantify the dynamics changes of Phosphatidylinositol 3,4,5-trisphosphate (PtdIns (3,4,5) P3) within and during fast and slow turnover rates of FA.Methods:In this study, we developed a protein purification MDA-MB-231 breast cancer cell line was used as a model in this study due to high metastatic and motile. These cells were co-transfected with GFP- paxillin/vinculin, as FA marker, and the GFP/mCherry-Btk-PH, as a biosensor to visualize PtdIns (3,4,5) P3. Confocal time-lapse images were used to monitor changes or differences in the local generation of PtdIns (3,4,5) P3 within and during assembly and disassembly of FA. Following transfection, immunostaining was used to examine the spatial co-localization between FA and PtdIns (3,4,5) P3.Results:Our data demonstrated that PtdIns (3,4,5) P3 co-localized with FAs and increase during assembly and decline during disassembly of FA which exhibits slow turnover rates and was in a constant level during assembly and disassembly of FA that displays fast turnover rates.DiscussionOur result suggested that the dynamic changes of PtdIns (3,4,5) P3, it may depend on components undergo turnover, such that early, nascent FA displays fast turnover rates and mature FA exhibits slow turnover rates. Thus, the local enrichment of PtdIns (3,4,5) P3 enhances FA assembly and disassembly activation.Key Words: Cancer cell migration, Focal adhesion turnover, MDA-MB-231 cell line, PtdIns (3,4,5) P3 相似文献
10.
Vishnu Vardhan Krishnamurthy John S. KhamoEllen Cho Cara SchornakKai Zhang 《Analytical biochemistry》2015
Precise DNA manipulation is critical for molecular biotechnology. Restriction enzyme-based approaches are limited by their requirement of specific enzyme sites. Restriction-free cloning has greatly improved the flexibility and speed of precise DNA assembly. Most of these approaches focus on DNA assembly rather than gene removal. Here we present a polymerase chain reaction (PCR)-based cloning method that allows removal of multiple gene segments from plasmids without using restriction enzymes and thermostable ligase. We demonstrate simultaneous removal of three gene segments from a plasmid. This approach could be beneficial to DNA library construction, genetic and protein engineering, and synthetic biology. 相似文献