排序方式: 共有2条查询结果,搜索用时 15 毫秒
1
1.
Atropisomerism in Rilpivirine hydrochloride: Spectroscopic characterization of Rilpivirine and related impurities
下载免费PDF全文
![点击此处可从《Chirality》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Senthilkumar Natarajan Hiriyanna Salmara Ganeshbhat Sujeet Shrivastava Srimurugan Sankareswaran Pramod Kumar 《Chirality》2018,30(8):966-973
Nuclear magnetic resonance (NMR) technique has been used to find the property of atropisomerism in Rilpivirine hydrochloride by variable temperature analysis and various 2D techniques. Both the Rilpivirine hydrochloride (E‐isomer) and Impurity‐A (Z‐isomer) isomers have been differentiated and confirmed by NMR and ultraviolet techniques. Preparative high‐performance liquid chromatography isolation for Impurity‐A is followed by spectroscopic (NMR, mass spectra, and infrared) investigation that provides a perfect solution for determination of the structure of Rilpivirine and related impurities. 相似文献
2.
4-Thialysine (S-(2-aminoethyl)-l-cysteine) is an analog of lysine. It has been used as an alternative substrate for lysine in enzymatic reactions. Site-directed
isotopomers are often needed for elucidation of mechanism of reactions. 4-Thialysine can be synthesized by reacting cysteine
with 2-bromoethylamine, an important reagent in chemical-modification rescue (CMR) of proteins. Here, we present the synthesis
of 4-thia-[6-13C]lysine, one of the isotopomers of 4-thialysine, from commercially available starting material [2-13C]glycine via formation of five intermediates including 2-amino[2-13C]ethanol and 2-bromo[1-13C]ethylamine. The compounds were characterized using various spectroscopic techniques. Moreover, we discuss that our strategy
would provide access to site-directed isotopomers of 2-aminoethanol, 2-bromoethylamine and 4-thialysine. Biological activity
of 4-thia-[6-13C]lysine was tested in the enzymatic reaction of lysine 5,6-aminomutase. 相似文献
1