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Sunil Kumar Kota Prabhas Ranjan Tripathy Siva Krishna Kota Sruti Jammula 《Indian journal of human genetics》2013,19(3):358-359
Down''s syndrome (DS) is known to be associated with autoimmune disease including type 1 diabetes. To the best of our knowledge, there are no reports of DS with type 2 diabetes mellitus in the literature. We hereby report two cases of DS with type 2 diabetes. 相似文献
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Fam60a defines a variant Sin3a‐Hdac complex in embryonic stem cells required for self‐renewal 下载免费PDF全文
Gundula Streubel Darren J Fitzpatrick Giorgio Oliviero Andrea Scelfo Bruce Moran Sudipto Das Nayla Munawar Ariane Watson Kieran Wynne Gian Luca Negri Eugene T Dillon SriGanesh Jammula Karsten Hokamp Darran P O'Connor Diego Pasini Adrian P Bracken 《The EMBO journal》2017,36(15):2216-2232
Sin3a is the central scaffold protein of the prototypical Hdac1/2 chromatin repressor complex, crucially required during early embryonic development for the growth of pluripotent cells of the inner cell mass. Here, we compare the composition of the Sin3a‐Hdac complex between pluripotent embryonic stem (ES) and differentiated cells by establishing a method that couples two independent endogenous immunoprecipitations with quantitative mass spectrometry. We define the precise composition of the Sin3a complex in multiple cell types and identify the Fam60a subunit as a key defining feature of a variant Sin3a complex present in ES cells, which also contains Ogt and Tet1. Fam60a binds on H3K4me3‐positive promoters in ES cells, together with Ogt, Tet1 and Sin3a, and is essential to maintain the complex on chromatin. Finally, we show that depletion of Fam60a phenocopies the loss of Sin3a, leading to reduced proliferation, an extended G1‐phase and the deregulation of lineage genes. Taken together, Fam60a is an essential core subunit of a variant Sin3a complex in ES cells that is required to promote rapid proliferation and prevent unscheduled differentiation. 相似文献
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Pietro Vella Andrea Scelfo SriGanesh Jammula Fulvio Chiacchiera Kristine Williams Alessandro Cuomo Alessandra Roberto Jesper Christensen Tiziana Bonaldi Kristian Helin Diego Pasini 《Molecular cell》2013,49(4):645-656
Highlights? Ogt forms a complex with Tet1 and Tet2 in the nucleus of embryonic stem cells ? Ogt preferentially associates with promoter regions in proximity of TSS ? Ogt shows >90% of colocalization with Tet1 at methylation-free CpG-rich elements ? Tet1 is required for global Ogt chromatin recruitment regulating its activity 相似文献
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Enrico Massignani Alessandro Cuomo Daniele Musiani SriGanesh Jammula Giulio Pavesi Tiziana Bonaldi 《Proteomics》2019,19(5)
Heavy methyl Stable Isotope Labeling with Amino acids in Cell culture (hmSILAC) is a metabolic labeling strategy employed in proteomics to increase the confidence of global identification of methylated peptides by MS. However, to this day, the automatic and robust identification of heavy and light peak doublets from MS‐raw data of hmSILAC experiments is a challenging task, for which the choice of computational methods is very limited. Here, hmSEEKER, a software designed to work downstream of a MaxQuant analysis for in‐depth search of MS peak pairs that correspond to light and heavy methyl‐peptide within MaxQuant‐generated tables is described with good sensitivity and specificity. The software is written in Perl, and its code and user manual are freely available at Bitbucket ( https://bit.ly/2scCT9u ). 相似文献
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Sridhara Babu Pepalla Subba Rao Jammula Hanumaiah Telikepalli Kesava Rao Bhattiprolu Kolluru Venkata Jagannadha Rao 《Phytochemistry》1991,30(12):4193-4194
A new naphthalene glucoside lactone was isolated from the acetone extract of the stem bark of Rhamnus wightii. Cynodontin, chrysophanol, physcion, musizin, lupeol, sitosterol, 7-hydroxy-5-methoxyphthalide, emodin, sitosterol glycoside, β-sorigenin are the known compounds; β-sorigenin may be an artifact of its glucoside. The co-occurrence of two lactone ring compounds, 7-hydroxy-5-methoxyphthalide and the naphthalide glucoside is the significant feature of this plant. 相似文献
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