全文获取类型
收费全文 | 67篇 |
免费 | 5篇 |
出版年
2019年 | 2篇 |
2018年 | 1篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 2篇 |
2013年 | 10篇 |
2012年 | 5篇 |
2011年 | 4篇 |
2010年 | 4篇 |
2009年 | 5篇 |
2008年 | 3篇 |
2006年 | 2篇 |
2005年 | 1篇 |
2004年 | 1篇 |
2003年 | 2篇 |
2002年 | 1篇 |
1999年 | 1篇 |
1993年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1948年 | 1篇 |
1928年 | 1篇 |
排序方式: 共有72条查询结果,搜索用时 15 毫秒
1.
A simple and yet reliable silver impregnation method, using potassium ferrocyanide, for demonstrating nervous tissue of the rat central nervous system embedded in paraffin or paraplast is described. The method reported here is compared and discussed with earlier techniques using potassium dicyanoargentate, potassium ferrocyanide and potassium ferricyanide. 相似文献
2.
Summary Structures identified as annulate lamellae, lamellar bodies and subsurface cisternae were found in neurons of the hyperstriatum accessorium of the avian forebrain. Annulate lamellar arrays with up to six lamellae were present in the larger somata. The lamellae were made up of fused smooth-surfaced cisternae forming pores or annuli and were surrounded by a dense filamentous to granular material. Stacks of nonfenestrated, parallel, regularly spaced cisternae, designated as lamellar bodies, also appeared in the cytoplasm. When flattened they were reminiscent of the electron dense subsurface cisternae. Continuity could be demonstrated between peripherally located subsurface cisternae and lamellar bodies. The dense filamentous to finely granular substance was also located between these structures. Annulate lamellae, lamellar bodies and subsurface cisternae were always observed in conjunction with the rough endoplasmic reticulum. The functional significance of these structural associations is considered. 相似文献
3.
Summary Ultrastructural reactions of neurons of the avian forebrain following tri-ortho-cresyl-phosphate (TOCP) poisoning are described. These neurons show a marked increase in the rough endoplasmic reticulum (RER), with RER specializations such as lamellar bodies and subsurface cisternae, as well as a proliferation of the Golgi complex and neurofilaments. In addition, an increase in the number of dense bodies and mitochondrial osmiophilia is noted. Similar changes can also be observed in the neuroglia. These alterations appear 10–13 days after TOCP ingestion. 相似文献
4.
P E Spoerri 《Acta anatomica》1978,101(4):325-333
The relationship between microtubules and the lipoprotein pigment found in senile Cynomolgus brain and senile human brain biopsy material was investigated. Numerous microtubules were present in all parts of the cytoplasm and within the pigment areas, running parallel or obliquely to the pigment bodies and being associated with its lateral aspects. Microtubules also occurred in the periphery of neurons or appearing to enter the perineuronal oligodendrocytes. These observations indicate a possible role of microtubules in the transport of pigment bodies. The oligodendrocyte from human brain biopsy material has definitely taken the role of a phagocyte in ingesting pigment bodies. Its numerous microtubules may offer a fasting moving system for disposing off pigment residures to the capillary endothelium. 相似文献
5.
Summary The ultrastructure of neurons in spinal ganglia of the domestic fowl poisoned with tri-ortho-cresyl-phosphate (TOCP) shows characteristic changes. The light neurons react to TOCP by a marked increase in the number of neurofilaments. These neurons also contain mitochondria in various degenerative stages. Several of the altered mitochondria show an increasing osmiophilia. Some of the darker neurons display a hypertrophy of the endoplasmic reticulum or a relative increase of neurofilaments. The mitochondria in some of these cells show early stages of degeneration. These changes appear 13 days after TOCP ingestion. 相似文献
6.
MARIA E. MCNAMARA PATRICK J. ORR TOM MANZOCCHI LUIS ALCALÁ PERE ANADÓN ENRIQUE PEÑALVER 《Lethaia: An International Journal of Palaeontology and Stratigraphy》2012,45(2):210-226
McNamara, M.E., Orr, P.J., Manzocchi, T., Alcalá, L., Anadón, P. & Peñalver, E. 2011: Biological controls upon the physical taphonomy of exceptionally preserved salamanders from the Miocene of Rubielos de Mora, northeast Spain. Lethaia, Vol. 45, pp. 210–226. The middle Miocene Rubielos de Mora Konservat‐Lagerstätte of northeast Spain is hosted within profundal, finely laminated, lacustrine mudstones. The diverse biota includes abundant salamanders. Most individuals died during separate episodes and sank rapidly postmortem. Specimens are typically preserved in dorso‐ventral aspect, the most hydrodynamically stable orientation. The near‐cylindrical morphology of the body, however, allowed some carcasses to settle in or subsequently re‐orientate into, lateral orientations. Loss of skeletal elements (i.e. reduced completeness) reflects their location within the body and followed a distal to proximal trend. Two stages are identified: initial loss of a small number of phalanges, followed by loss of more proximal limb bones plus additional phalanges. Disarticulation is more complex: it occurred via several mechanisms (notably, abdominal rupture and re‐orientation of part of the body and limbs during decay) and shows no consistent pattern among specimens. The physical taphonomy of the salamanders is controlled predominantly by intrinsic biological factors, i.e. the geometry of the body and of individual skeletal elements, the orientation, inherent strength and location of specific joints and the extent to which soft tissues, particularly the skin, persist during decay. These biological factors probably control patterns of physical taphonomy of other fossil tetrapods with a similar skeletal configuration. □Articulation, completeness, Konservat‐Lagerstätten, orientation, quantitative taphonomy, salamanders. 相似文献
7.
Steve Horvath Abu NM Nazmul-Hossain Rodney PE Pollard Frans GM Kroese Arjan Vissink Cees GM Kallenberg Fred KL Spijkervet Hendrika Bootsma Sara A Michie Sven U Gorr Ammon B Peck Chaochao Cai Hui Zhou David TW Wong 《Arthritis research & therapy》2012,14(6):1-13
Bone tissue has an exceptional quality to regenerate to native tissue in response to injury. However, the fracture repair process requires mechanical stability or a viable biological microenvironment or both to ensure successful healing to native tissue. An improved understanding of the molecular and cellular events that occur during bone repair and remodeling has led to the development of biologic agents that can augment the biological microenvironment and enhance bone repair. Orthobiologics, including stem cells, osteoinductive growth factors, osteoconductive matrices, and anabolic agents, are available clinically for accelerating fracture repair and treatment of compromised bone repair situations like delayed unions and nonunions. Preclinical and clinical studies using biologic agents like recombinant bone morphogenetic proteins have demonstrated an efficacy similar or better than that of autologous bone graft in acute fracture healing. A lack of standardized outcome measures for comparison of biologic agents in clinical fracture repair trials, frequent off-label use, and a limited understanding of the biological activity of these agents at the bone repair site have limited their efficacy in clinical applications. 相似文献
8.
Lei P Ayton S Finkelstein DI Spoerri L Ciccotosto GD Wright DK Wong BX Adlard PA Cherny RA Lam LQ Roberts BR Volitakis I Egan GF McLean CA Cappai R Duce JA Bush AI 《Nature medicine》2012,18(2):291-295
The microtubule-associated protein tau has risk alleles for both Alzheimer's disease and Parkinson's disease and mutations that cause brain degenerative diseases termed tauopathies. Aggregated tau forms neurofibrillary tangles in these pathologies, but little is certain about the function of tau or its mode of involvement in pathogenesis. Neuronal iron accumulation has been observed pathologically in the cortex in Alzheimer's disease, the substantia nigra (SN) in Parkinson's disease and various brain regions in the tauopathies. Here we report that tau-knockout mice develop age-dependent brain atrophy, iron accumulation and SN neuronal loss, with concomitant cognitive deficits and parkinsonism. These changes are prevented by oral treatment with a moderate iron chelator, clioquinol. Amyloid precursor protein (APP) ferroxidase activity couples with surface ferroportin to export iron, but its activity is inhibited in Alzheimer's disease, thereby causing neuronal iron accumulation. In primary neuronal culture, we found loss of tau also causes iron retention, by decreasing surface trafficking of APP. Soluble tau levels fall in affected brain regions in Alzheimer's disease and tauopathies, and we found a similar decrease of soluble tau in the SN in both Parkinson's disease and the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model. These data suggest that the loss of soluble tau could contribute to toxic neuronal iron accumulation in Alzheimer's disease, Parkinson's disease and tauopathies, and that it can be rescued pharmacologically. 相似文献
9.
P E Spoerri 《Acta anatomica》1983,117(4):346-354
The minor active component of bee venom was applied to mouse neuroblastoma cultures. The cytological changes observed are reported. After 8-10 h of incubation with 5 micrograms/ml of apamin in the culture medium, considerable retractions of the processes are apparent. Electron microscopically, the alterations seen are predominantly found in the subcellular organelles. The peculiar configuration of the endoplasmic reticulum (ER) is striking. Concentric whorls of cisternae seem to engulf the remaining ground substance. Following a 24-hour incubation with 5 micrograms/ml of apamin, the cell membrane disintegrates. A deeply infolded nucleus, vacuoles and remnants of cell organelles are present. The previously intact synapses are totally degenerated. Similar experiments using lower concentrations of apamin do not depict any apparent changes either light or electron microscopically. 相似文献