排序方式: 共有11条查询结果,搜索用时 31 毫秒
1.
Flekhter O. B. Karachurina L. T. Nigmatullina L. R. Sapozhnikova T. A. Baltina L. A. Zarudii F. S. Galin F. Z. Spirikhin L. V. Tolstikov G. A. Plyasunova O. A. Pokrovskii A. G. 《Russian Journal of Bioorganic Chemistry》2002,28(6):494-500
The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3O,28O-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, antiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids. 相似文献
2.
O. B. Flekhter L. T. Karachurina V. V. Poroikov L. P. Nigmatullina L. A. Baltina F. S. Zarudii V. A. Davydova L. V. Spirikhin I. P. Baikova F. Z. Galin G. A. Tolstikov 《Russian Journal of Bioorganic Chemistry》2000,26(3):192-200
Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, andp-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin
esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and silibor.
These experimental data were in a good agreement with the computer prediction of their biological activity. Betulin 3,28-bishemiphthalate
was more effective than carsil in models of experimental hepatitis caused by carbon tetrachloride, tetracycline, and ethanol. 相似文献
3.
The effect of pyridine on the electronic structure and conformational state of cell phosphatidylcholine was studied by the methods of quantum chemistry and 13C NMR spectroscopy. It was shown that the interaction of the pi-system of pyridine electrons with the choline group of phosphatidylcholine leads to the formation of a complex. Changes in the conformational states due to the formation of this complex were revealed. 相似文献
4.
A. V. Rybina I. S. Shepelevich R. F. Talipov F. Z. Galin L. V. Spirikhin 《Russian Journal of Bioorganic Chemistry》2008,34(4):480-482
The interaction of betulin diacetate with formaldehyde by the Prins reaction in various media was studied. As a result, 3β,28-di-O-acetyl-30-hydroxymethyl-(20)29-lupene, 3β-acetyl-28-hydroxy-(20)29-lupene, and 3β,28-di-O-acetoxy-19-(5′,6′-dihydro-2′H-pyran-4′-yl)-20,29,30-trinorlupane were obtained. 相似文献
5.
Flekhter OB Karachurina LT Nigmatullina LR Sapozhnikova TA Baltina LA Zarudiĭ FS Galin FZ Spirikhin LV Tolstikov GA Pliasunova OA 《Bioorganicheskaia khimiia》2002,28(6):543-550
The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3,28-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, untiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2002, vol. 28, no. 6; see also http://www.maik.ru. 相似文献
6.
Flekhter OB Medvedeva NI Kukovinets OS Spirikhin LV Galkin EG Galin FZ Golovanov DG Pavlova NI Savinova OV Boreko EI Tolstikov GA 《Bioorganicheskaia khimiia》2007,33(6):629-634
A reductive transformation of the peroxide products of ozonolysis of derivatives of 3beta-O-acetyl-22(17-->28)-abeo-lupa-17(28),20(29)-diene and the subsequent intramolecular ketalization led to a compound with a trioxane fragment. This is a new approach to a skeletal modification of triterpenoid cycle E. An activity of the synthesized compounds was found toward the viruses of type A influenza and herpes simplex. 相似文献
7.
O. B. Kazakova E. V. Tret’yakova I. E. Smirnova L. V. Spirikhin G. A. Tolstikov I. V. Chudov G. V. Bazekin A. F. Ismagilova 《Russian Journal of Bioorganic Chemistry》2010,36(2):257-262
Under the action of PCl5, the Beckman rearrangement of a 3: 1 mixture of Z- and E-isomeres of 18β-hydro-xydihydroquinopimaric acid resulted in 5′-caprolactam and isomeric caprolactams containing fragments
of cyclic ether. Z- and E-ketoximes were separated as acetates. Using a carrageenan inflammation model, we demonstrated that the anti-inflammatory
activity of quinopimaric acid derivatives was comparable with that of diclofenac. 相似文献
8.
O. B. Flekhter N. I. Medvedeva O. S. Kukovinets L. V. Spirikhin E. G. Galkin F. Z. Galin D. G. Golovanov N. I. Pavlova O. V. Savinova E. I. Boreko G. A. Tolstikov 《Russian Journal of Bioorganic Chemistry》2007,33(6):584-588
A reductive transformation of the peroxide products of ozonolysis of derivatives of 3β-O-acetyl-22(17→28)-abeo-lupa-17(28),20(29)-diene and the subsequent intramolecular ketalization led to a compound with a trioxane fragment. This is a new approach to a skeletal modification of triterpenoid cycle E. An activity of the synthesized compounds was found toward the viruses of type A influenza and herpes simplex. 相似文献
9.
T.?M.?GabbasovEmail author E.?M.?Tsyrlina L.?V.?Spirikhin V.?T.?Danilov M.?S.?Yunusov 《Russian Journal of Bioorganic Chemistry》2005,31(4):383-386
Uraline, a new norditerpenoid alkaloid, was isolated from aerial parts of Delphinium uralense. The structure of 1α,7,8-trihydroxy-6β,14α,16β-trimethoxy-18-N-(2-methyl)succinylanthranoyloxyaconane was ascribed to the new compound on the basis of 1H and 13C NMR, IR, and mass spectra. The known alkaloids methyllycaconitine and delcorine were also isolated from the plant.__________Translated from Bioorganicheskaya Khimiya, Vol. 31, No. 4, 2005, pp. 425–429.Original Russian Text Copyright © 2005 by Gabbasov, Tsyrlina, Spirikhin, Danilov, Yunusov. 相似文献
10.
Gabbasov TM Tsyrlina EM Spirikhin LV Danilov VT Iunusov MS 《Bioorganicheskaia khimiia》2005,31(4):425-429
Uraline, a new norditerpenoid alkaloid, was isolated from aerial parts of Delphinium uralense. The structure of 1alpha,7,8-trihydroxy-6beta,14alpha,16beta-trimethoxy-18-N-(2-methyl)succinylanthranoyloxyaconane was ascribed to the new compound on the basis of 1H and 13C NMR, IR, and mass spectra. The known alkaloids methyllycaconitine and delcorine were also isolated from the plant. 相似文献