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Erdogan H Fadillioglu E Ozgocmen S Sogut S Ozyurt B Akyol O Ardicoglu O 《Prostaglandins, leukotrienes, and essential fatty acids》2004,71(3):149-152
The aim of this study was to investigate effect of dietary omega-3 fatty acid supplementation on the indices of in vivo lipid peroxidation and oxidant/antioxidant status of plasma in rats. The plasma thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO) levels, and activities of xanthine oxidase (XO), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were studied in male Wistar Albino rats after ingestion of 0.4 g/kg fish oil (rich in omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid) for 30 days and compared to untreated control rats. The rats in the treated group had significantly higher SOD activity (P < 0.001), NO levels (P < 0.01) and decreased TBARS levels (P < 0.05) with respect to controls whereas GSH-Px and XO activities were not significantly different between the groups. None of the measured parameters had significant correlation with each other in both groups. We conclude that dietary supplementation of omega-3 fatty acids may enhance resistance to free radical attack and reduce lipid peroxidation. These results support the notion that omega-3 fatty acids may be effective dietary supplements in the management of various diseases in which oxidant/antioxidant defence mechanisms are decelerated. 相似文献
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Sogut S Yonden Z Kaya H Oktar S Tutanc M Yilmaz HR Yigit A Ozcelik N Gali E 《Genetics and molecular research : GMR》2011,10(2):828-833
Oxidative stress may be contributory to the pathophysiology of the abnormalities that underlie the clinical course of sickle cell anemia. We looked for a possible genetic association between the functional polymorphism Ala-9Val in the human Mn-SOD gene and sickle cell anemia. One hundred and twenty-seven patients with sickle cell anemia and 127 healthy controls were recruited into the study. Alanine versus valine polymorphism in the signal peptide of the Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with the restriction enzyme NgoMIV. In the sickle cell anemia patients, the frequency of Val/Val genotype was approximately 1.4-fold lower and that of Ala/Val was 1.3-fold higher compared to the controls. No significant difference in genotype frequencies was found between patients and controls (χ(2) = 4.561, d.f. = 2, P = 0.101). The Val-9 was the most common allele in patient and healthy subjects. No significant difference in allele frequencies was found between patients and controls (χ(2) = 1.496, d.f. = 1, P = 0.221). We conclude that the Mn-SOD gene polymorphism is not associated with sickle cell anemia. 相似文献
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Protective agent, erdosteine, against cisplatin-induced hepatic oxidant injury in rats 总被引:5,自引:0,他引:5
Cisplatin, one of the most active cytotoxic agents against cancer, has several toxicities. Hepatotoxicity is one of them occurred
during high doses treatment. The aim of this study was to determine the effects of erdosteine against cisplatin-induced liver
injury through tissue oxidant/antioxidant parameters and light microscopic evaluation. The rats were randomly divided into
three groups: control (n=5), cisplatin (10 mg/kg, n=6) and cisplatin+erdosteine (50 mg/kg/day oral erdosteine, n=8) groups. The rats were sacrificed at the 5th day of cisplatin treatment. The liver tissues were examined with light microscopy
and oxidant/antioxidant biochemical parameters. The malondialdehyde (MDA) and nitric oxide (NO) levels were increased in the
cisplatin group in comparison with the control and cisplatin+erdosteine groups (p<0.05). There was no significant difference in MDA and NO levels between control and cisplatin+erdosteine groups. The activities
of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were higher in cisplatin+erdosteine group
than cisplatin group (p<0.05). However, the CAT and GSH-Px activities were significantly lower in cisplatin group than in control group (p<0.05). The light microscopic examination revealed that cytoplasmic changes especially around cells of central vein were observed
in cisplatin group. Hepatocellular vacuolization was seen in these cells. In the cisplatin plus erdosteine group, a decrease
in cytoplasmic changes with the hepatocytes and sinusoidal dilatations around cells of central vein were noticed in as compared
to cisplatin group. In the light of microscopic and biochemical results, it was concluded that cisplatin-induced liver damage
in high dose and erdosteine prevented this toxic side effect by the way of its antioxidant and radical scavenging effects.
(Mol Cell Biochem 278: 79–84, 2005) 相似文献
4.
Ibrahim Celik Mehmet Ali Sogut Ercan Ozkaynak Sami Doganlar Anne Frary 《Molecular breeding : new strategies in plant improvement》2016,36(10):137
Natural root-knot nematode resistance genes are unique resources to control this major pest in pepper (Capsicum annuum). Although four genes (Me1, Me3, Me7 and N) conferring broad-spectrum resistance were mapped to a cluster in a 28-cm interval on chromosome P9, limited markers targeting this region were available. In the present study, the Me-gene cluster was structurally annotated for resistance genes to develop markers targeting the N gene. As a result, the Me-gene cluster (4.07 Mb in size) was found to contain three resistance gene hotspots. In addition, a SSR maker tightly linked to the N gene (0.8 cM away) was developed for marker-assisted selection in pepper. 相似文献
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Koc A Narci A Duru M Gergerlioglu HS Akaydin Y Sogut S 《Molecular and cellular biochemistry》2005,280(1-2):193-199
Testicular torsion and detorsion are important clinical problems for infertile man and oxidative stress may have a role in
this clinical situation. The aim of this study was to investigate the protective role of erdosteine, an antioxidant, on unilateral
testicular reperfusion injury in rats. The rats were divided into four groups including seven rats in each group: control,
torsion, torsion/detorsion and torsion/detorsion+erdosteine. Rats, except the sham operation group, were subjected to left
unilateral torsion (720∘ rotation in the clockwise direction) without including the epididymis. The experiments were finished after sham operation
time for control, 120 min torsion for torsion group and 120 min torsion and 240 min detorsion for torsion/detorsion groups.
Bilateral orchiectomy was performed for all groups of rats. The ipsilateral and controlateral testis were divided into two
pieces to analyse biochemical parameters and to investigate the light microscopic view.
Malondialdehyde level of ipsilateral testis was increased in torsion and torsion/detorsion groups in comparison with the other
groups (p < 0.05). Erdosteine treatment ameliorated lipid peroxidation after torsion/detorsion in ipsilateral testis (p < 0.05). Also, xanthine oxidase activity of ipsilateral testis was increased in torsion/detorsion group in comparison with
the others (p < 0.05). Nitric oxide (NO) level of ipsilateral testis was higher in all experimental groups than sham operated control group
(p < 0.05). Also, NO level of torsion group was increased in comparison with detorsion groups (p < 0.05). Erdosteine treatment caused increased glutathione peroxidase activity in comparison with torsion and torsion/detorsion
groups and catalase activity in comparison with the other groups in ipsilateral testis (p < 0.05). Superoxide dismutase activity of ipsilateral testis was higher in torsion/detorsion and torsion/detorsion+erdosteine
groups than control and torsion groups (p < 0.05). The biochemical parameters were not affected in controlateral testis in all groups. Torsion, torsion/detorsion and
torsion/detorsion+erdosteine groups showed ipsilateral testicular damage in the histological examination, but the specimens
from torsion/detorsion had a significantly greater histological injury than those from the other groups (p < 0.05). Control rats showed normal seminiferous tubule morphology. Rats in torsion group had slight-to-moderate disruption
of the seminiferous epithelium. Rats in torsion/detorsion group displayed moderate-to-severe disruption of the seminiferous
epithelium. In all animals from torsion/detorsion+erdosteine group, the testicular tissues were affected with slight-to-moderate
degenerative changes of the seminiferous epithelium. Administration of erdosteine resulted in a significantly reduced histological
damage associated with torsion of the spermatic cord compared with torsion/detorsion. In all groups, the contralateral testes
were histologically normal.
In conclusion, the results clearly displayed that erdosteine treatment may have a protective role on testicular torsion/detorsion
injury. (Mol Cell Biochem xxx: 193–199, 2005) 相似文献
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Intra- and Extra-cellular Thiol–Disulfide Homeostasis in Blood of Patients with Alcohol Use Disorder
Sogut I. Senat A. Kabadayi-Sahin E. Duymaz T. Erel O. 《Journal of Evolutionary Biochemistry and Physiology》2021,57(4):962-971
Journal of Evolutionary Biochemistry and Physiology - Alcohol use disorder (AUD) is the loss of a person's quality of life due to increased alcohol consumption and the failure of alcohol... 相似文献
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Yusuf Soylu Ersan Arslan Mustafa Sogut Bulent Kilit Filipe Manuel Clemente 《Biology of sport / Institute of Sport》2021,38(4):555
This study aimed to compare the effects of 8-week self-paced high-intensity interval training (HIIT) vs. self-paced moderate-intensity continuous training (MICT) on the physical performance and psychophysiological responses of young adults. Twenty-eight recreationally active young adults (age: 21.1 ± 1.6 years) were randomly assigned to either the self-paced HIIT (n = 14) or the MICT (n = 14) group training protocol. The HIIT consisted of two 12–24 x 30 seconds of high-intensity runs interspersed by 30 seconds of recovery. The MICT completed 24–48 minutes of continuous running. Before and after the 8-week interventions the following tests were completed: maximum oxygen consumption (V̇O2max) estimated from the Yo-Yo Intermittent Recovery Test level 1 (YYIRTL-1), repeated sprint ability (RSA), 10–30-m sprint test, change of direction test (T-drill), countermovement jump (CMJ) and squat jump (SJ), and triple hop distance test (THD). Training rating of perceived exertion (RPE) and physical activity enjoyment scale (PACES) were assessed during the training programme. The HIIT resulted in greater improvement in YYIRTL-1, V̇O2max, RSA and T-drill performances compared to the MICT. Furthermore, RPE and PACES values were higher in the HIIT than the MICT. This study suggested that self-paced HIIT may be a more effective training regime to improve aerobic fitness with greater physical enjoyment in recreationally active young adults. 相似文献
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Irmak MK Fadillioglu E Sogut S Erdogan H Gulec M Ozer M Yagmurca M Gozukara ME 《Cell biochemistry and function》2003,21(3):283-289
Oxygen-derived free radicals have been implicated in the pathogenesis of cerebral injury after ischaemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, exhibits antioxidant properties. The purpose of the present study was to investigate the effects of ischaemia and subsequent reperfusion on rat brain and to investigate the effects of two free radical scavengers, CAPE and alpha-tocopherol, on this in vivo model of cerebral injury. Ischaemia was induced by bilateral occlusion of the carotid arteries for 20 min and reperfusion was achieved by releasing the occlusion to restore the circulation for 20 min. Control rats underwent a sham operation. CAPE at 10 micromol kg(-1) or alpha-tocopherol at 25 micromol kg(-1) was administered intraperitoneally before reperfusion. Reperfusion led to significant increase in the activity of xanthine oxidase and higher malondialdehyde levels in the brain. Acute administration of both CAPE and alpha-tocopherol suppressed ischaemia-reperfusion-induced cerebral lipid peroxidation and injury, but CAPE seems to offer a better therapeutic advantage over alpha-tocopherol. 相似文献
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