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Galante Yves M. Merlini Luca Silvetti Tiziana Campia Paola Rossi Bianca Viani Fiorenza Brasca Milena 《Applied microbiology and biotechnology》2018,102(11):4687-4702
Applied Microbiology and Biotechnology - New biomaterials from renewable sources and the development of “functionalized biopolymers” are fields of growing industrial interest. Plant... 相似文献
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Foetal liver tRNA phe in rat hepatoma 总被引:1,自引:0,他引:1
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Medullary thyroid carcinoma (MTC) is a rare calcitonin producing neuroendocrine tumour that originates from the parafollicular C-cells of the thyroid gland. The RET proto-oncogene encodes the RET receptor tyrosine kinase, with consequently essential roles in cell survival, differentiation and proliferation. Somatic or germline mutations of the RET gene play an important role in this neoplasm in development of sporadic and familial forms, respectively. Genetic diagnosis has an important role in differentiating sporadic from familiar MTC. Furthermore, depending on the location of the mutation, patients can be classified into risk classes. Therefore, genetic screening of the RET gene plays a critical role not only in diagnosis but also in assessing the prognosis and course of MTC. 相似文献
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Alessandro Belletti Mario Musu Simona Silvetti Omar Saleh Laura Pasin Fabrizio Monaco Ludhmila A. Hajjar Evgeny Fominskiy Gabriele Finco Alberto Zangrillo Giovanni Landoni 《PloS one》2015,10(11)
Introduction
Hypotensive state is frequently observed in several critical conditions. If an adequate mean arterial pressure is not promptly restored, insufficient tissue perfusion and organ dysfunction may develop. Fluids and catecholamines are the cornerstone of critical hypotensive states management. Catecholamines side effects such as increased myocardial oxygen consumption and development of arrhythmias are well known. Thus, in recent years, interest in catecholamine-sparing agents such as vasopressin, terlipressin and methylene blue has increased; however, few randomized trials, mostly with small sample sizes, have been performed. We therefore conducted a meta-analysis of randomized trials to investigate the effect of non-catecholaminergic vasopressors on mortality.Methods
PubMed, BioMed Central and Embase were searched (update December 31st, 2014) by two independent investigators. Inclusion criteria were: random allocation to treatment, at least one group receiving a non-catecholaminergic vasopressor, patients with or at risk for vasodilatory shock. Exclusion criteria were: crossover studies, pediatric population, non-human studies, studies published as abstract only, lack of data on mortality. Studied drugs were vasopressin, terlipressin and methylene blue. Primary endpoint was mortality at the longest follow-up available.Results
A total of 1,608 patients from 20 studies were included in our analysis. The studied settings were sepsis (10/20 studies [50%]), cardiac surgery (7/20 [35%]), vasodilatory shock due to any cause (2/20 [19%]), and acute traumatic injury (1/20 [5%]). Overall, pooled estimates showed that treatment with non-catecholaminergic agents improves survival (278/810 [34.3%] versus 309/798 [38.7%], risk ratio = 0.88, 95% confidence interval = 0.79 to 0.98, p = 0.02). None of the drugs was associated with significant reduction in mortality when analyzed independently. Results were not confirmed when analyzing studies with a low risk of bias.Conclusions
Catecholamine-sparing agents in patients with or at risk for vasodilatory shock may improve survival. Further researches on this topic are needed to confirm the finding. 相似文献5.
Summary Cystic fibrosis (CF) is a relatively uncommon genetic disorder in the Sardinian population. In this study, we have defined
the frequency of the most common CF mutation (ΔF508) and carried out a genotypephenotype correlation analysis in a group of
21 patients with CF and of Sardinian descent. We detected the ΔF508 mutation in 24 (57%) out of the 42 CF chromosome investigated.
This mutation was found in the homozygous state in 9 patients and in the heterozygous state in 6 patients. The remaining 6
patients had other mutations. The ΔF508 mutation was associated only with the KM19/XV2c 2 1 haplotype. Genotype-phenotype
correlation analysis did not give clear-cut results, probably because of the small number of patients investigated. However,
out of the four patients with meconium ileus, three were homozygous and one was heterozygous for the ΔF508 mutation, confirming
that the presence of ΔF508 or other severe mutations in the homozygous state is the prerequisite for the development of meconium
ileus. 相似文献
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Present-day G-6-PD deficit in Sardinia with respect to malarial morbidity and mortality in the past 总被引:1,自引:0,他引:1
E Sanna R Bruno G G Cosseddu G Floris A Salis M Silvetti 《Zeitschrift für Morphologie und Anthropologie》1990,78(2):257-267
Current Gd- gene distribution in Sardinia is analyzed using data on a sample of 4300 Sardinian males examined at the time of their pre-military checkup from 1983 to 1986, as well as data in the literature. Also examined is the relationship of current G-6-PD deficit distribution to probable malarial morbidity and mortality during the first half of this century. From data on deficit distribution by altitude analyzed for 100 villages of the island, the authors suggest the possibility of using altitude above sea level to replace incidence of malaria, which was used in the past only as an indicative, rather than substitutive, parameter. The authors also corroborate the hypothesis that G-6-PD deficit distribution is basically a consequence of selection caused by malarial endemicity, although several other factors may have interacted to influence Gd- gene incidence and distribution. 相似文献
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Two cases of liver lobe torsion in a white‐lipped tamarin (Saguinus labiatus) and an Alaotran gentle lemur (Hapalemur alaotrensis)
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S. Silvetti M. Kubiak W.S.M. Justice M.F. Stidworthy 《Journal of medical primatology》2017,46(6):356-358
This paper describes liver lobe torsion in a white‐lipped tamarin (Saguinus labiatus) and an Alaotran gentle lemur (Hapalemur alaotrensis). Both animals had a history of acute collapse, and diagnosis was made post‐mortem. To the authors’ knowledge, these are the first reported cases of this pathology in non‐human primates. 相似文献
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