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Smit DJ Boersma M Schnack HG Micheloyannis S Boomsma DI Hulshoff Pol HE Stam CJ de Geus EJ 《PloS one》2012,7(5):e36896
We investigated the development of the brain's functional connectivity throughout the life span (ages 5 through 71 years) by measuring EEG activity in a large population-based sample. Connectivity was established with Synchronization Likelihood. Relative randomness of the connectivity patterns was established with Watts and Strogatz' (1998) graph parameters C (local clustering) and L (global path length) for alpha (~10 Hz), beta (~20 Hz), and theta (~4 Hz) oscillation networks. From childhood to adolescence large increases in connectivity in alpha, theta and beta frequency bands were found that continued at a slower pace into adulthood (peaking at ~50 yrs). Connectivity changes were accompanied by increases in L and C reflecting decreases in network randomness or increased order (peak levels reached at ~18 yrs). Older age (55+) was associated with weakened connectivity. Semi-automatically segmented T1 weighted MRI images of 104 young adults revealed that connectivity was significantly correlated to cerebral white matter volume (alpha oscillations: r = 33, p<01; theta: r = 22, p<05), while path length was related to both white matter (alpha: max. r = 38, p<001) and gray matter (alpha: max. r = 36, p<001; theta: max. r = 36, p<001) volumes. In conclusion, EEG connectivity and graph theoretical network analysis may be used to trace structural and functional development of the brain. 相似文献
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Manousos A. Klados Kassia Kanatsouli Ioannis Antoniou Fabio Babiloni Vassiliki Tsirka Panagiotis D. Bamidis Sifis Micheloyannis 《PloS one》2013,8(8)
The two core systems of mathematical processing (subitizing and retrieval) as well as their functionality are already known and published. In this study we have used graph theory to compare the brain network organization of these two core systems in the cortical layer during difficult calculations. We have examined separately all the EEG frequency bands in healthy young individuals and we found that the network organization at rest, as well as during mathematical tasks has the characteristics of Small World Networks for all the bands, which is the optimum organization required for efficient information processing. The different mathematical stimuli provoked changes in the graph parameters of different frequency bands, especially the low frequency bands. More specific, in Delta band the induced network increases it’s local and global efficiency during the transition from subitizing to retrieval system, while results suggest that difficult mathematics provoke networks with higher cliquish organization due to more specific demands. The network of the Theta band follows the same pattern as before, having high nodal and remote organization during difficult mathematics. Also the spatial distribution of the network’s weights revealed more prominent connections in frontoparietal regions, revealing the working memory load due to the engagement of the retrieval system. The cortical networks of the alpha brainwaves were also more efficient, both locally and globally, during difficult mathematics, while the fact that alpha’s network was more dense on the frontparietal regions as well, reveals the engagement of the retrieval system again. Concluding, this study gives more evidences regarding the interaction of the two core systems, exploiting the produced functional networks of the cerebral cortex, especially for the difficult mathematics. 相似文献
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Stavros I. Dimitriadis Nikolaos A. Laskaris Vasso Tsirka Sofia Erimaki Michael Vourkas Sifis Micheloyannis Spiros Fotopoulos 《Cognitive neurodynamics》2012,6(1):107-113
Symbolic dynamics is a powerful tool for studying complex dynamical systems. So far many techniques of this kind have been
proposed as a means to analyze brain dynamics, but most of them are restricted to single-sensor measurements. Analyzing the
dynamics in a channel-wise fashion is an invalid approach for multisite encephalographic recordings, since it ignores any
pattern of coordinated activity that might emerge from the coherent activation of distinct brain areas. We suggest, here,
the use of neural-gas algorithm (Martinez et al. in IEEE Trans Neural Netw 4:558–569, 1993) for encoding brain activity spatiotemporal dynamics in the form of a symbolic timeseries. A codebook of k prototypes, best
representing the instantaneous multichannel data, is first designed. Each pattern of activity is then assigned to the most
similar code vector. The symbolic timeseries derived in this way is mapped to a network, the topology of which encapsulates
the most important phase transitions of the underlying dynamical system. Finally, global efficiency is used to characterize
the obtained topology. We demonstrate the approach by applying it to EEG-data recorded from subjects while performing mental
calculations. By working in a contrastive-fashion, and focusing in the phase aspects of the signals, we show that the underlying
dynamics differ significantly in their symbolic representations. 相似文献
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We studied how maturation influences the organization of functional brain networks engaged during mental calculations and in resting state. Surface EEG measurements from 20 children (8–12 years) and 25 students (21–26 years) were analyzed. Interregional synchronization of brain activity was quantified by means of Phase Lag Index and for various frequency bands. Based on these pairwise estimates of functional connectivity, we formed graphs which were then characterized in terms of local structure [local efficiency (LE)] and overall integration (global efficiency). The overall data analytic scheme was applied twice, in a static and time-varying mode. Our results showed a characteristic trend: functional segregation dominates the network organization of younger brains. Moreover, in childhood, the overall functional network possesses more prominent small-world network characteristics than in early acorrect in xmldulthood in accordance with the Neural Efficiency Hypothesis. The above trends were intensified by the time-varying approach and identified for the whole set of tested frequency bands (from δ to low γ). By mapping the time-indexed connectivity patterns to multivariate timeseries of nodal LE measurements, we carried out an elaborate study of the functional segregation dynamics and demonstrated that the underlying network undergoes transitions between a restricted number of stable states, that can be thought of as “network-level microstates”. The rate of these transitions provided a robust marker of developmental and task-induced alterations, that was found to be insensitive to reference montage and independent component analysis denoising.
Electronic supplementary material
The online version of this article (doi:10.1007/s11571-015-9330-8) contains supplementary material, which is available to authorized users. 相似文献
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