Polymorphism of the Tumor Necrosis Factor α Gene in Patients with Infiltrative Tuberculosis from the Bashkortostan Populations

The polymorphism at position –308 of the TNF- gene promoter was analyzed in three ethnic groups and in patients with infiltrative pulmonary tuberculosis from Bashkortostan. No interethnic difference in allele or genotype frequency distribution was observed. The frequency of allele TNF2 in tuberculosis patients was significantly higher than in controls (² = 11.69, p = 0.001), suggesting association of this allele with higher risk of pulmonary tuberculosis or with markedly disturbed immune response.     

Insertion Polymorphism of the CYP2E1 Gene in Patients with Infiltrative Pulmonary Tuberculosis from Bashkortostan

Insertion polymorphism Ins₉₆ of the CYP2E1 promoter region was for the first time studied in three ethnic groups of Bashkortostan. Population-specific features of genotype and allele frequency distributions were observed. The CYP2E1 polymorphism was associated with infiltrative pulmonary tuberculosis in the Bashkortostan population.