Effect of homologous immunoglobulin with normal anti-tissue antibodies on the development of strontium-90-induced osteosarcomas in rats

In experiments on Wistar rats it was shown that homologous immunoglobulin (a single dose of 25 mg/kg), with normal antitissue antibodies, subcutaneously injected in the following manner: a single injection 90 days or 6 months, or double injection 3 and 6 months after intraperitoneal administration of strontium 90 (11.1 kBq/kg) reduces osteosarcoma occurrence and increases the average lifetime of animals.     

Evaluation of the effect of dose rate and dose absorption on the long-term radiation consequences in rats chronically taking in 90Sr

The effects of exposure to 90Sr which was given with food with daily doses 18.5 kBq per animal for 1-12 months, 37 kBq per animal for 1-10 months, 74 kBq per animal for 1-8 months and 148 kBq per animal for 1-6 months on mortality patterns in unimbred white rats were investigated. Hazard models were used to evaluate dose rate and accumulated dose influence on radiation-related trends in mortality. The time-dependent risk of death from all causes and from osteosarcomas depended on the dose rate. The risk of death from causes other than osteosarcoma depended on the dose rate and the accumulated dose. To predict time-dependent risk of death it was better to use the least time to calculate the dose rate--1 day.     

The effect of joint, radiation and chemical lesions in rats on their reproductive function]

In experiments with rats exposed to the combined radiation and chemical effects it was shown that fertilization of an ovum and the development of fetus did not vary from these indices in the controls. Viability of sucking rat pups isolated from poison did not vary from the controls as well. Sensitivity of posterity to the toxic effect of chlorophos and lindane was found to increase.     

Changes in the content of carbohydrate-containing proteins in the liver of rats chronically exposed to pesticides combined with total gamma irradiation

A study was made of the chronic effect of pesticides, within a wide range of doses, combined with whole-body gamma-irradiation, on the content of carbohydrate-containing proteins of rat liver. The extent to which disturbances in the carbohydrate-containing protein metabolism were manifest was shown to depend upon dose and time of action of the damaging factors. As determined by certain parameters, the combined effect of pesticides and gamma-radiation at the biochemical level was additive, and it was more than additive as estimated by a number of other tests.     

Dynamics of the plasma injected into the gap of a plasma opening switch across a strong magnetic field

A method is proposed to increase the linear charge density transferred through a plasma opening switch (POS) and, accordingly, reduce the POS diameter by enhancing the external magnetic field in the POS gap. Results are presented from experimental studies of the dynamics of the plasma injected into the POS gap across a strong magnetic field. The possibility of closing the POS gap by the plasma injected across an external magnetic field of up to 60 kG is demonstrated.     

Experimental verification of the technique for calculating a plasma opening switch and its matching to the load

A technique for calculating a plasma opening switch in an external magnetic field and its matching to a load the impedance of which increases with time was verified experimentally. The experiments were performed in the RS-20 facility both in the absence of a load and with various inductive loads. The amplitude of the voltage pulse at the input of the plasma opening switch was 0.36–0.84 MV, the current amplitude was 280–320 kA, and the pulse duration was ～2 μs, whereas the corresponding parameters of the output pulse were 0.8–3.2 MV, 0–240 kA, and ～100 ns.     

RS-20MR High-Current Relativistic Electron Beam Generator Based on a Plasma Opening Switch and Its Applications

Plasma Physics Reports - A modified scheme of the RS-20MR generator is presented that can be used not only as a source of high-power pulsed hard X-ray emission (the dose power per 1-L volume in...     

DNA content of rat organs damaged by strontium-90 during the development of delayed effects

In this report the results are submitted concerning the frequency of disorders in the nucleic acid metabolism in the bone marrow, peripheral blood, thymus and spleen of rats during a year after single injection of 90Sr. Irrespective of the time lapsed after the injection of the radionuclide 10-30% of animals did not exhibit any substantial changes in the nucleic acid metabolism in all the organs under study except the thymus.     

Development of long-term radiation effects in rats after whole-body fractionated gamma-irradiation

Albino male rats were divided into four groups and exposed to gamma-radiation (137Cs) for 80, 40, 20 and 10 days at dose rates of 0.25, 0.5, 1.0 and 2.0 Gy/day, respectively. The development of lesions and remote aftereffects was shown to depend upon conditions of formation of the absorbed dose. With fractionated irradiation at dose rates above 1.0 Gy/day the dose-rate played a major role in producing the effect.